IDM3_ARATH
ID IDM3_ARATH Reviewed; 463 AA.
AC Q9SYQ0;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Increased DNA methylation 3 {ECO:0000303|PubMed:25684209};
DE AltName: Full=Alpha-crystallin domain-containing protein 51.9 {ECO:0000303|PubMed:16531488};
DE Short=AtAcd51.9 {ECO:0000303|PubMed:16531488};
GN Name=IDM3 {ECO:0000303|PubMed:25684209};
GN Synonyms=Acd51.9 {ECO:0000303|PubMed:16531488};
GN OrderedLocusNames=At1g20870 {ECO:0000312|Araport:AT1G20870};
GN ORFNames=F9H16.15 {ECO:0000312|EMBL:AAD30605.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|Proteomes:UP000006548};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NOMENCLATURE.
RX PubMed=16531488; DOI=10.1104/pp.105.073841;
RA Ma C., Haslbeck M., Babujee L., Jahn O., Reumann S.;
RT "Identification and characterization of a stress-inducible and a
RT constitutive small heat-shock protein targeted to the matrix of plant
RT peroxisomes.";
RL Plant Physiol. 141:47-60(2006).
RN [4]
RP INDUCTION BY HEAT.
RX PubMed=25002145; DOI=10.1016/j.molcel.2014.06.008;
RA Qian W., Miki D., Lei M., Zhu X., Zhang H., Liu Y., Li Y., Lang Z.,
RA Wang J., Tang K., Liu R., Zhu J.K.;
RT "Regulation of active DNA demethylation by an alpha-crystallin domain
RT protein in Arabidopsis.";
RL Mol. Cell 55:361-371(2014).
RN [5]
RP FUNCTION, INDUCTION BY HEAT, SUBCELLULAR LOCATION, AND INTERACTION WITH
RP MBD7; IDM1 AND IDM2.
RX PubMed=25684209; DOI=10.1016/j.molcel.2015.01.009;
RA Lang Z., Lei M., Wang X., Tang K., Miki D., Zhang H., Mangrauthia S.K.,
RA Liu W., Nie W., Ma G., Yan J., Duan C.G., Hsu C.C., Wang C., Tao W.A.,
RA Gong Z., Zhu J.K.;
RT "The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation
RT to limit DNA hyper-methylation and transcriptional gene silencing.";
RL Mol. Cell 57:971-983(2015).
CC -!- FUNCTION: Acts as an anti-silencing factor that prevents DNA
CC hypermethylation and gene repression (PubMed:25684209).
CC {ECO:0000269|PubMed:25684209}.
CC -!- SUBUNIT: Interacts with MBD7 (via C-terminus), IDM1 and IDM2
CC (PubMed:25684209). Part of a complex made of MBD7, IDM1, IDM2 and IDM3
CC (PubMed:25684209). {ECO:0000269|PubMed:25684209}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25684209}.
CC -!- INDUCTION: Not regulated by heat. {ECO:0000269|PubMed:25002145,
CC ECO:0000269|PubMed:25684209}.
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DR EMBL; AC007369; AAD30605.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30033.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59103.1; -; Genomic_DNA.
DR PIR; C86341; C86341.
DR RefSeq; NP_001319056.1; NM_001332473.1.
DR RefSeq; NP_173511.1; NM_101940.2.
DR AlphaFoldDB; Q9SYQ0; -.
DR SMR; Q9SYQ0; -.
DR STRING; 3702.AT1G20870.1; -.
DR PaxDb; Q9SYQ0; -.
DR PRIDE; Q9SYQ0; -.
DR ProteomicsDB; 250670; -.
DR EnsemblPlants; AT1G20870.1; AT1G20870.1; AT1G20870.
DR EnsemblPlants; AT1G20870.2; AT1G20870.2; AT1G20870.
DR GeneID; 838680; -.
DR Gramene; AT1G20870.1; AT1G20870.1; AT1G20870.
DR Gramene; AT1G20870.2; AT1G20870.2; AT1G20870.
DR KEGG; ath:AT1G20870; -.
DR Araport; AT1G20870; -.
DR TAIR; locus:2037380; AT1G20870.
DR eggNOG; ENOG502QRHQ; Eukaryota.
DR HOGENOM; CLU_043084_0_0_1; -.
DR InParanoid; Q9SYQ0; -.
DR OMA; SDNPRCS; -.
DR OrthoDB; 1008408at2759; -.
DR PhylomeDB; Q9SYQ0; -.
DR PRO; PR:Q9SYQ0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SYQ0; baseline and differential.
DR Genevisible; Q9SYQ0; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1901537; P:positive regulation of DNA demethylation; IMP:TAIR.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR039321; IDM2/3-like.
DR PANTHER; PTHR34661; PTHR34661; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..463
FT /note="Increased DNA methylation 3"
FT /id="PRO_0000432654"
FT REGION 169..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..332
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 51932 MW; A5CEC11D6E36664C CRC64;
MSLYSDGLSS DQYFLVNFIM SNYLGPDVYS DNPRCSSSQR LARGLPPYTL MHIGSSSLTV
SQLQNLYYNV LRNAKSSLLL HPDMIYMYLK GYLPLEPSGK FPQFTHFFPT NLHPQKRYSP
SHEIVKGIVV IDDPAVGFIN KEELQRFRCL SRLDDLKIDR VTSLSPRVNL DESRETEQDC
SRNGDATANG VVTNEDYNSS GELQETCKRK EGEDAVASCV ISEPERLSGD IPESQGMKQD
CSRNGESAFS GIVSDQDYYS FVKLPETCKR KNKEEEAVTG HAVSGTSKTP ERFRETYKRR
RFKNSSKKAT NKNGETLMER EKTDKPIPFS SEMKESDAEP SVVTTGTASK ETLGSSVGVV
DIGVNKVAYF FQVALPGVRK DYGEFSCEIE SDGKVILEGS TTRGEKNIKR HSRVFEMNIR
KLCPPGPFKL CFNLPGPVDP RLFSPNFRSD GIFEGVIIRH KNS
