IDNK_ECOLI
ID IDNK_ECOLI Reviewed; 187 AA.
AC P39208; Q2M641;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Thermosensitive gluconokinase;
DE EC=2.7.1.12;
DE AltName: Full=Gluconate kinase 1;
GN Name=idnK; Synonyms=gntV; OrderedLocusNames=b4268, JW4225;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT from 92.8 through 100 minutes.";
RL Nucleic Acids Res. 23:2105-2119(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-187.
RC STRAIN=B;
RA Pucci M.J., Discotto L.F., Dougherty T.J.;
RL Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION.
RX PubMed=9658018; DOI=10.1128/jb.180.14.3704-3710.1998;
RA Bausch C., Peekhaus N., Utz C., Blais T., Murray E., Lowary T., Conway T.;
RT "Sequence analysis of the GntII (subsidiary) system for gluconate
RT metabolism reveals a novel pathway for L-idonic acid catabolism in
RT Escherichia coli.";
RL J. Bacteriol. 180:3704-3710(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-gluconate = 6-phospho-D-gluconate + ADP + H(+);
CC Xref=Rhea:RHEA:19433, ChEBI:CHEBI:15378, ChEBI:CHEBI:18391,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58759, ChEBI:CHEBI:456216;
CC EC=2.7.1.12;
CC -!- PATHWAY: Carbohydrate acid metabolism; L-idonate degradation.
CC -!- SIMILARITY: Belongs to the gluconokinase GntK/GntV family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U14003; AAA97165.1; -; Genomic_DNA.
DR EMBL; U00096; AAC77225.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE78265.1; -; Genomic_DNA.
DR EMBL; M96355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S56494; S56494.
DR RefSeq; NP_418689.1; NC_000913.3.
DR RefSeq; WP_000896738.1; NZ_SSUV01000014.1.
DR AlphaFoldDB; P39208; -.
DR SMR; P39208; -.
DR BioGRID; 4261380; 10.
DR BioGRID; 850426; 7.
DR IntAct; P39208; 8.
DR STRING; 511145.b4268; -.
DR jPOST; P39208; -.
DR PaxDb; P39208; -.
DR PRIDE; P39208; -.
DR EnsemblBacteria; AAC77225; AAC77225; b4268.
DR EnsemblBacteria; BAE78265; BAE78265; BAE78265.
DR GeneID; 946066; -.
DR KEGG; ecj:JW4225; -.
DR KEGG; eco:b4268; -.
DR PATRIC; fig|1411691.4.peg.2435; -.
DR EchoBASE; EB2072; -.
DR eggNOG; COG3265; Bacteria.
DR HOGENOM; CLU_077168_1_0_6; -.
DR InParanoid; P39208; -.
DR OMA; ENFIQVS; -.
DR PhylomeDB; P39208; -.
DR BioCyc; EcoCyc:GLUCONOKINI-MON; -.
DR BioCyc; MetaCyc:GLUCONOKINI-MON; -.
DR UniPathway; UPA00793; -.
DR PRO; PR:P39208; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046316; F:gluconokinase activity; IDA:EcoCyc.
DR GO; GO:0046177; P:D-gluconate catabolic process; IBA:GO_Central.
DR GO; GO:0019521; P:D-gluconate metabolic process; IMP:EcoCyc.
DR GO; GO:0046183; P:L-idonate catabolic process; IMP:EcoCyc.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd02021; GntK; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR006001; Therm_gnt_kin.
DR PANTHER; PTHR43442; PTHR43442; 1.
DR Pfam; PF01202; SKI; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR01313; therm_gnt_kin; 1.
PE 3: Inferred from homology;
KW ATP-binding; Gluconate utilization; Kinase; Nucleotide-binding;
KW Reference proteome; Transferase.
FT CHAIN 1..187
FT /note="Thermosensitive gluconokinase"
FT /id="PRO_0000084151"
FT BINDING 10..17
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 187 AA; 21004 MW; DA85C86951037ECC CRC64;
MAGESFILMG VSGSGKTLIG SKVAALLSAK FIDGDDLHPA KNIDKMSQGI PLSDEDRLPW
LERLNDASYS LYKKNETGFI VCSSLKKQYR DILRKGSPHV HFLWLDGDYE TILARMQRRA
GHFMPVALLK SQFEALERPQ ADEQDIVRID INHDIANVTE QCRQAVLAIR QNRICAKEGS
ASDQRCE
