ID   IDNR_ECOLI              Reviewed;         332 AA.
AC   P39343; Q2M645;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=HTH-type transcriptional regulator IdnR;
DE   AltName: Full=L-idonate regulatory protein;
GN   Name=idnR; Synonyms=yjgS; OrderedLocusNames=b4264, JW4221;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=7610040; DOI=10.1093/nar/23.12.2105;
RA   Burland V.D., Plunkett G. III, Sofia H.J., Daniels D.L., Blattner F.R.;
RT   "Analysis of the Escherichia coli genome VI: DNA sequence of the region
RT   from 92.8 through 100 minutes.";
RL   Nucleic Acids Res. 23:2105-2119(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION.
RX   PubMed=9658018; DOI=10.1128/jb.180.14.3704-3710.1998;
RA   Bausch C., Peekhaus N., Utz C., Blais T., Murray E., Lowary T., Conway T.;
RT   "Sequence analysis of the GntII (subsidiary) system for gluconate
RT   metabolism reveals a novel pathway for L-idonic acid catabolism in
RT   Escherichia coli.";
RL   J. Bacteriol. 180:3704-3710(1998).
CC   -!- FUNCTION: Idn operon regulator. May repress gntKU and gntT genes when
CC       growing on L-idonate. {ECO:0000269|PubMed:9658018}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U14003; AAA97161.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC77221.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE78261.1; -; Genomic_DNA.
DR   PIR; S56490; S56490.
DR   RefSeq; NP_418685.1; NC_000913.3.
DR   RefSeq; WP_001309159.1; NZ_SSUV01000014.1.
DR   AlphaFoldDB; P39343; -.
DR   SMR; P39343; -.
DR   BioGRID; 4262722; 6.
DR   IntAct; P39343; 3.
DR   STRING; 511145.b4264; -.
DR   PaxDb; P39343; -.
DR   PRIDE; P39343; -.
DR   EnsemblBacteria; AAC77221; AAC77221; b4264.
DR   EnsemblBacteria; BAE78261; BAE78261; BAE78261.
DR   GeneID; 949058; -.
DR   KEGG; ecj:JW4221; -.
DR   KEGG; eco:b4264; -.
DR   PATRIC; fig|1411691.4.peg.2439; -.
DR   EchoBASE; EB2427; -.
DR   eggNOG; COG1609; Bacteria.
DR   HOGENOM; CLU_037628_6_3_6; -.
DR   InParanoid; P39343; -.
DR   OMA; EAPYDHI; -.
DR   PhylomeDB; P39343; -.
DR   BioCyc; EcoCyc:G7891-MON; -.
DR   PRO; PR:P39343; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd01392; HTH_LacI; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR000843; HTH_LacI.
DR   InterPro; IPR046335; LacI/GalR-like_sensor.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   Pfam; PF00356; LacI; 1.
DR   Pfam; PF13377; Peripla_BP_3; 1.
DR   SMART; SM00354; HTH_LACI; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF53822; SSF53822; 1.
DR   PROSITE; PS00356; HTH_LACI_1; 1.
DR   PROSITE; PS50932; HTH_LACI_2; 1.
PE   4: Predicted;
KW   DNA-binding; Gluconate utilization; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..332
FT                   /note="HTH-type transcriptional regulator IdnR"
FT                   /id="PRO_0000107960"
FT   DOMAIN          6..60
FT                   /note="HTH lacI-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT   DNA_BIND        8..27
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ   SEQUENCE   332 AA;  37567 MW;  9F18972E86DAFBF7 CRC64;
     MRNHRISLQD IATLAGVTKM TVSRYIRSPK KVAKETGERI AKIMEEINYI PNRAPGMLLN
     AQSYTLGILI PSFQNQLFAD ILAGIESVTS EHNYQTLIAN YNYDRDSEEE SVINLLSYNI
     DGIILSEKYH TIRTVKFLRS ATIPVVELMD VQGERLDMEV GFDNRQAAFD MVCTMLEKRV
     RHKILYLGSK DDTRDEQRYQ GYCDAMMLHN LSPLRMNPRA ISSIHLGMQL MRDALSANPD
     LDGVFCTNDD IAMGALLLCR ERNLAVPEQI SIAGFHGLEI GRQMIPSLAS VITPRFDIGR
     MAAQMLLSKI KNNDHNHNTV DLGYQIYHGN TL