ID   APC5_SCHPO              Reviewed;         744 AA.
AC   Q9P4W7; Q9C1X6;
DT   30-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 3.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Anaphase-promoting complex subunit 5;
DE   AltName: Full=20S cyclosome/APC complex protein apc5;
GN   Name=apc5; ORFNames=SPAC959.09c, SPAP32A8.01c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   REVISION OF GENE MODEL.
RX   PubMed=21511999; DOI=10.1126/science.1203357;
RA   Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA   Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA   Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA   Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA   French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA   Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA   Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA   Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA   Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA   Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT   "Comparative functional genomics of the fission yeasts.";
RL   Science 332:930-936(2011).
RN   [3]
RP   SUBUNIT.
RX   PubMed=12477395; DOI=10.1016/s0960-9822(02)01331-3;
RA   Yoon H.-J., Feoktistova A., Wolfe B.A., Jennings J.L., Link A.J.,
RA   Gould K.L.;
RT   "Proteomics analysis identifies new components of the fission and budding
RT   yeast anaphase-promoting complexes.";
RL   Curr. Biol. 12:2048-2054(2002).
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC       that controls progression through mitosis and the G1 phase of the cell
CC       cycle. The APC/C is thought to confer substrate specificity and, in the
CC       presence of ubiquitin-conjugating E2 enzymes, it catalyzes the
CC       formation of protein-ubiquitin conjugates that are subsequently
CC       degraded by the 26S proteasome.
CC   -!- SUBUNIT: The APC/C is composed of at least 13 subunits: apc1, apc2,
CC       nuc2, apc4, apc5, cut9, apc8, apc10, apc11, hcn1, apc13, apc14 and
CC       apc15. {ECO:0000269|PubMed:12477395}.
CC   -!- SIMILARITY: Belongs to the APC5 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB93016.3; -; Genomic_DNA.
DR   RefSeq; XP_001713082.2; XM_001713030.2.
DR   AlphaFoldDB; Q9P4W7; -.
DR   SMR; Q9P4W7; -.
DR   BioGRID; 279777; 6.
DR   ComplexPortal; CPX-763; Anaphase-Promoting Complex variant 1.
DR   ComplexPortal; CPX-764; Anaphase-Promoting Complex variant 2.
DR   ComplexPortal; CPX-765; Anaphase-Promoting Complex variant 3.
DR   ComplexPortal; CPX-766; Anaphase-Promoting Complex variant 4.
DR   IntAct; Q9P4W7; 2.
DR   STRING; 4896.SPAC959.09c.1; -.
DR   iPTMnet; Q9P4W7; -.
DR   MaxQB; Q9P4W7; -.
DR   PaxDb; Q9P4W7; -.
DR   EnsemblFungi; SPAC959.09c.1; SPAC959.09c.1:pep; SPAC959.09c.
DR   PomBase; SPAC959.09c; apc5.
DR   VEuPathDB; FungiDB:SPAC959.09c; -.
DR   eggNOG; KOG4322; Eukaryota.
DR   HOGENOM; CLU_367284_0_0_1; -.
DR   InParanoid; Q9P4W7; -.
DR   OMA; KCVVEYE; -.
DR   Reactome; R-SPO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q9P4W7; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005680; C:anaphase-promoting complex; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; EXP:PomBase.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; IBA:GO_Central.
DR   InterPro; IPR037679; Apc5.
DR   InterPro; IPR026000; Apc5_dom.
DR   PANTHER; PTHR12830; PTHR12830; 1.
DR   Pfam; PF12862; ANAPC5; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Mitosis; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..744
FT                   /note="Anaphase-promoting complex subunit 5"
FT                   /id="PRO_0000064624"
SQ   SEQUENCE   744 AA;  86049 MW;  AF3A7475798EE831 CRC64;
     MQSPAMSMVT PIFPIPLKTN SSKKNFYTTF LTPHKLTLCL LIELYAHRII QPQHCVPFLD
     LVLGYFNPND SQPQTLTRIH DITSHLPSSI EEYSVYSLLH ERLWSLHSFE DIHEIFISLG
     NYIEGVYDSE EEAPHMLFSS SSLLSIFLRK CVVEYEQFSF EQGVQFFKSF LQYRAPSMDF
     QHEGIEFCKI NVRHELMNLA SNKTLLQLAF GSIPVSRSSR DIEQLTQVQI EHMQKFGCAL
     PLEMKEKLHD LLEVEENNLN TSYYCKFLNS WFSGDYQQSV ENLCRYFDHI MHSDEKVSYQ
     YALLNLAMLQ ADFGCNEEAL HAIEDTINTA RESGDTACLN FALAWMFEFK RSQYSNPSPE
     KNENDDQILE HLARNSQKAQ LPILQTTVHL LQVQKFLDDG SSLIGVFSNL TKAFALFCAN
     ESFDGFPRYM DLLQSIWYRL GCSILSMTYI SIYQKNHVHD SPALDLLQSL ITKAWRYAEL
     GRWLDVATIL STAEVQSQRS FQCAHLYGRE KTFIYLSKAI DEKNHMDATL YLKNLNGFRH
     DKMSTFRTQL YALRLDISLG NLSQAIEGID KLLEEPEKLA IEWVLQLMFL KVDIYMRTEM
     SNRAVFELLE IIQMASSNYL RLYLLRGLCT LCLIGELDCF TAIDLLDSLI PDIIAADNKP
     LLALAFHAFA SLQIKHLDLL QPSRMFVIQL LDSAIDGYRA CYMVEMQKTV VRLKIQYLRQ
     INDPALQPNI EQYCSRFYSD NLLN