ID   IE1_HHV6U               Reviewed;         941 AA.
AC   Q69567; Q69227; Q69228; Q69229; Q69568;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   02-JUN-2021, entry version 55.
DE   RecName: Full=Immediate-early protein 1;
DE            Short=IE1;
DE   AltName: Full=Protein RF2/RF3/RF4;
DE   AltName: Full=pRF2/pRF3/pRF4;
GN   Name=U90/U89; Synonyms=RF4;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1654446; DOI=10.1128/jvi.65.10.5381-5390.1991;
RA   Martin M.E., Nicholas J., Thomson B.J., Newman C., Honess R.W.;
RT   "Identification of a transactivating function mapping to the putative
RT   immediate-early locus of human herpesvirus 6.";
RL   J. Virol. 65:5381-5390(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
RN   [3]
RP   ALTERNATIVE SPLICING.
RX   PubMed=12367753; DOI=10.1016/s0168-1702(02)00126-0;
RA   Papanikolaou E., Kouvatsis V., Dimitriadis G., Inoue N., Arsenakis M.;
RT   "Identification and characterization of the gene products of open reading
RT   frame U86/87 of human herpesvirus 6.";
RL   Virus Res. 89:89-101(2002).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=2; Synonyms=IE1 protein, Protein U90-U89;
CC         IsoId=Q69567-1; Sequence=Displayed;
CC       Name=1; Synonyms=IE2 protein, Protein U90-U86/87;
CC         IsoId=Q77Z83-1; Sequence=External;
CC       Name=3; Synonyms=IE-100;
CC         IsoId=Q77Z83-2; Sequence=External;
CC       Name=4; Synonyms=IE-55;
CC         IsoId=Q77Z83-3; Sequence=External;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA43849.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAA43850.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AAA43851.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA58339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; M73681; AAA43849.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; M73681; AAA43850.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; M73681; AAA43851.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; X83413; CAA58338.1; -; Genomic_DNA.
DR   EMBL; X83413; CAA58339.1; ALT_SEQ; Genomic_DNA.
DR   PIR; B40506; B40506.
DR   PIR; C40506; C40506.
DR   PIR; D40506; D40506.
DR   RefSeq; NP_042983.2; NC_001664.2.
DR   PRIDE; Q69567; -.
DR   DNASU; 1487968; -.
DR   GeneID; 1487968; -.
DR   KEGG; vg:1487968; -.
DR   Proteomes; UP000009295; Genome.
DR   InterPro; IPR005507; HHV6-IE.
DR   Pfam; PF03753; HHV6-IE; 3.
PE   4: Predicted;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..941
FT                   /note="Immediate-early protein 1"
FT                   /id="PRO_0000343644"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..632
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        567..599
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..622
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   941 AA;  104648 MW;  8E93A6E7D5EB1935 CRC64;
     MEPAKPSGNN MGSNDERMQD YRPDPMMEES IKEILEESLM CDTSFDDLII PGLESFGLII
     PESSNNIESN NVEEGSDGEL KTLAAQSAGN CIQSIGASVK AAMKQEQSDM EDKLIKCAGL
     LTQQQSMFIG LGLEQLSQLI NINLLSSAST KYVESYSKML HGKELDFFNW CEPRFIVFAC
     DKFDGLVKKV ASESRNLLLD LRANMNNDII KAVKDIFSKA TVTLDCQKLN QGATMLMMMA
     HNKEMSNPDI SSKDFCEKIN TLKQTLLEGK NEIVETNAKN MQILQTFAIK QMNQIFMDGC
     DKAFLKLNVN CKNLITAAKN LANTILQSIV ICSNEFSWQH LKLLRRGFKV TMLNMITQAC
     ECLESDYDDT GLIKPLTPLQ IMDGYINMNK NRQSSICDGN TDPSDSMILD LADFDDHGRY
     SEESSIESIH EDDDNKMYPC TPSPEVPGKS KYVGTFTENS RQSGDEQTNP NCVGTASVTD
     LGGPDNLNSI SGLQSCKNML LERLLDTQCD SVVEGTEQDG SYGNTLISEM MMFGYETDHS
     APYESESDNN DEIDYIANSD SAARTNNIHM NSTDENTPFS NSICSPPEVT PSKKNVKPKS
     MTPGSKPKKR VAKRKHVSSK SPKNKKIKTD QLPKAADVIV ISSESEDEED GDNIIGNSIL
     IKAIKSESDS ESSSESNDCT SEHKQLHLSD YDEVTNNGHC PSYGFPTPVF TIPIRSMQGT
     GGIKSKFIPK KNWIWYMKKT HQVDNCPIHN SENVDAKDDS DGTEAKHCFM NHFVPIKTDD
     EDYDKNNVSY IYNKIQNSKI DSGDIIPTKK LIIDMVMDNF MDLNDIIKQG ITKHCQDLCN
     KYNVVTPTTC EDDLNMTNSQ TFATTATQVF DPPVTGNNSS ILNIINDTTS QNDENRCTEG
     TSNSNEKCTN ISDCNSDGTE AFKLDGYPSD YDPFVENAQI Y