IE2_HHV6Z
ID IE2_HHV6Z Reviewed; 1520 AA.
AC Q9QJ16;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 29-SEP-2021, entry version 60.
DE RecName: Full=Immediate-early protein 2;
DE Short=IE2;
GN Name=U90/U86;
OS Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX NCBI_TaxID=36351;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA Pellett P.E.;
RT "Human herpesvirus 6B genome sequence: coding content and comparison with
RT human herpesvirus 6A.";
RL J. Virol. 73:8040-8052(1999).
CC -!- FUNCTION: Transcriptional transactivator. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with human UBE2I in the nucleus. Although this
CC interaction does not promote IE2 sumoylation, it represses
CC transactivation activity (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the herpesviridae IE2 family. {ECO:0000305}.
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DR EMBL; AF157706; AAD49674.1; -; Genomic_DNA.
DR RefSeq; NP_050265.1; NC_000898.1.
DR SMR; Q9QJ16; -.
DR PRIDE; Q9QJ16; -.
DR GeneID; 1497086; -.
DR KEGG; vg:1497086; -.
DR Proteomes; UP000006930; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR005028; Herpes_IE2_3.
DR Pfam; PF03361; Herpes_IE2_3; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Host nucleus; Host-virus interaction;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..1520
FT /note="Immediate-early protein 2"
FT /id="PRO_0000260224"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1072
FT /note="Interaction with human UBE2I"
FT /evidence="ECO:0000250"
FT REGION 1033..1278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..388
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1200
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1204..1223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1520 AA; 171363 MW; 0F498EEDCDF70F3D CRC64;
MKLSGLYHDA DVTHRQPLSE NTHQDPISSQ DSRKNSRTPQ DPRRAAQIHR QCTSSASNLP
SNGNNSIHMR FASELPDQVL QPMYASQNQT TNSQCNFTSL PYQPNYDAYR SIESSYRESR
NTDRGYDSNF RHHSHRPRGG KGRYDSRNYF NPNSKYQQPY GRFFPRSYNR RGRGHRLHDF
SNRPADLSYQ QYMHPNYEQY NPDLRMNNYK DVTQLTTNFN FQAQDYSMAF SQTSITTDPT
YVQSDNHNYP TKTQTTPETT KTKEHENAKD NKEHKKQQVS TSPDAISLSY RPSSQKMDLI
KKIYDTEVIP LPKEALIDNG SYCGVDTQKY KKTHIRCRSI QKTKGHSSQT INKHKVQKHN
ENHVPSRSDL KQRKSNQHED EAVTEARDFS KLDPLLSPLP MTPEPTLNFA VHKTKIHSDS
ELHHTKKNIH RSKTSLQDRV LISKHAPRAP TKDNSYKKHH DPKDTNDPKM KHSRGRTTSK
KNTANSNGHQ DVREVAVKNV SGKAAKNTSK KSDPSHNLHG KTSDEQYKTS PDNEKISTPP
KSKTHHCIHD SSSSEEGQYK SPNNSESNYG NCLSDKFYDN FTKTTPNSKT NHKTEESTEN
TDLNSFSNEN TNKTEIEDSN IIQPFSQLFC NETIIPSTSA CPTQETPSTM NRNCASKKHS
AGANKNLTDN SPIRSHSNPS SFTAFNKSNS GNSTMNSTSN GDECTDKKPN CSSTENKSET
SNQTNGENSD KPLSKTFTEV SDRASSRASS RASSRASSRA SSRASSRASS RASSRTSSRA
SSRAFSRASS RVSSRASSRA SSRASSRASS RASSRASGRA SGRASSRASS RVSSRASSRA
SSRASSRASS RASSRASSRV SSKASSRASS RASSRASSRA SSRASSRASS RASSRASSRA
SSRASSRASS RASSRASSRA SSRASSRASS RASSRASGRA SSKASSRASS RASGKTPNNK
LMSNIPSPQT YEKTSNKRKP RQIYCDSNKR QIYPHDTSIS TEAEVSEIKF RCGPELNFYK
NAAARLQSFN HNDQFYNPRF RPHIRTNRKK SESTNYTDSE SSTSRSRSHS RYSPDSLNTP
KRKKHKSGSS SISSSIEENS RSNSRTETGT DKLITFNYQH SRTRSSSSSS VSSSCSSSRS
KSWRKSRYKN SEDPATYSPR SRLQQLEKQT RPKSASRDKT KIKSPNHESK HRHADMFRNS
QKTGEKFPLD NSSPSNTHEQ SNHLENAIDQ EQKKTPKTTN TTTNTIYRPR DNQSNISRNT
TKCKKKRTRD DDSDSSMQNF FKKRISGTQK TDSEISEIEE ELSYREYVRR KEKKESAKYK
IHRGRVSTKD FRKLFRNTIR AFEYKQIPKK PFPENKLKEA VYNICSNGCS NTGAIIMYFT
RSKQVAEIIK TMQRELMIRP NITVSEPFKM NHAPPNYYDK DAINQFIELQ KQGPQELWDK
LENNTHDLFT RHSDVKTLMV YAATPIDFVM ASKICNKYAK DKPKEIVLRV CSIIDGDNSI
SIYNSVSRDF KSKYLTLSKC