位置:首页 > 蛋白库 > IE2_HHV6Z
IE2_HHV6Z
ID   IE2_HHV6Z               Reviewed;        1520 AA.
AC   Q9QJ16;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   29-SEP-2021, entry version 60.
DE   RecName: Full=Immediate-early protein 2;
DE            Short=IE2;
GN   Name=U90/U86;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Transcriptional transactivator. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with human UBE2I in the nucleus. Although this
CC       interaction does not promote IE2 sumoylation, it represses
CC       transactivation activity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae IE2 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF157706; AAD49674.1; -; Genomic_DNA.
DR   RefSeq; NP_050265.1; NC_000898.1.
DR   SMR; Q9QJ16; -.
DR   PRIDE; Q9QJ16; -.
DR   GeneID; 1497086; -.
DR   KEGG; vg:1497086; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005028; Herpes_IE2_3.
DR   Pfam; PF03361; Herpes_IE2_3; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Host nucleus; Host-virus interaction;
KW   Reference proteome; Repeat; Transcription; Transcription regulation.
FT   CHAIN           1..1520
FT                   /note="Immediate-early protein 2"
FT                   /id="PRO_0000260224"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..611
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          640..987
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1024..1072
FT                   /note="Interaction with human UBE2I"
FT                   /evidence="ECO:0000250"
FT   REGION          1033..1278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..279
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..388
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        418..438
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..473
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        509..531
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..553
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        554..571
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        640..707
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        714..973
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1056..1075
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1089..1141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1152..1170
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1171..1200
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1204..1223
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1233..1259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1264..1278
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1520 AA;  171363 MW;  0F498EEDCDF70F3D CRC64;
     MKLSGLYHDA DVTHRQPLSE NTHQDPISSQ DSRKNSRTPQ DPRRAAQIHR QCTSSASNLP
     SNGNNSIHMR FASELPDQVL QPMYASQNQT TNSQCNFTSL PYQPNYDAYR SIESSYRESR
     NTDRGYDSNF RHHSHRPRGG KGRYDSRNYF NPNSKYQQPY GRFFPRSYNR RGRGHRLHDF
     SNRPADLSYQ QYMHPNYEQY NPDLRMNNYK DVTQLTTNFN FQAQDYSMAF SQTSITTDPT
     YVQSDNHNYP TKTQTTPETT KTKEHENAKD NKEHKKQQVS TSPDAISLSY RPSSQKMDLI
     KKIYDTEVIP LPKEALIDNG SYCGVDTQKY KKTHIRCRSI QKTKGHSSQT INKHKVQKHN
     ENHVPSRSDL KQRKSNQHED EAVTEARDFS KLDPLLSPLP MTPEPTLNFA VHKTKIHSDS
     ELHHTKKNIH RSKTSLQDRV LISKHAPRAP TKDNSYKKHH DPKDTNDPKM KHSRGRTTSK
     KNTANSNGHQ DVREVAVKNV SGKAAKNTSK KSDPSHNLHG KTSDEQYKTS PDNEKISTPP
     KSKTHHCIHD SSSSEEGQYK SPNNSESNYG NCLSDKFYDN FTKTTPNSKT NHKTEESTEN
     TDLNSFSNEN TNKTEIEDSN IIQPFSQLFC NETIIPSTSA CPTQETPSTM NRNCASKKHS
     AGANKNLTDN SPIRSHSNPS SFTAFNKSNS GNSTMNSTSN GDECTDKKPN CSSTENKSET
     SNQTNGENSD KPLSKTFTEV SDRASSRASS RASSRASSRA SSRASSRASS RASSRTSSRA
     SSRAFSRASS RVSSRASSRA SSRASSRASS RASSRASGRA SGRASSRASS RVSSRASSRA
     SSRASSRASS RASSRASSRV SSKASSRASS RASSRASSRA SSRASSRASS RASSRASSRA
     SSRASSRASS RASSRASSRA SSRASSRASS RASSRASGRA SSKASSRASS RASGKTPNNK
     LMSNIPSPQT YEKTSNKRKP RQIYCDSNKR QIYPHDTSIS TEAEVSEIKF RCGPELNFYK
     NAAARLQSFN HNDQFYNPRF RPHIRTNRKK SESTNYTDSE SSTSRSRSHS RYSPDSLNTP
     KRKKHKSGSS SISSSIEENS RSNSRTETGT DKLITFNYQH SRTRSSSSSS VSSSCSSSRS
     KSWRKSRYKN SEDPATYSPR SRLQQLEKQT RPKSASRDKT KIKSPNHESK HRHADMFRNS
     QKTGEKFPLD NSSPSNTHEQ SNHLENAIDQ EQKKTPKTTN TTTNTIYRPR DNQSNISRNT
     TKCKKKRTRD DDSDSSMQNF FKKRISGTQK TDSEISEIEE ELSYREYVRR KEKKESAKYK
     IHRGRVSTKD FRKLFRNTIR AFEYKQIPKK PFPENKLKEA VYNICSNGCS NTGAIIMYFT
     RSKQVAEIIK TMQRELMIRP NITVSEPFKM NHAPPNYYDK DAINQFIELQ KQGPQELWDK
     LENNTHDLFT RHSDVKTLMV YAATPIDFVM ASKICNKYAK DKPKEIVLRV CSIIDGDNSI
     SIYNSVSRDF KSKYLTLSKC
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024