ID   IE63_ALHV1              Reviewed;         436 AA.
AC   O36407;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   02-JUN-2021, entry version 60.
DE   RecName: Full=Immediate-early phosphoprotein 57;
GN   Name=57;
OS   Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Macavirus.
OX   NCBI_TaxID=654901;
OH   NCBI_TaxID=9927; Connochaetes taurinus (Blue wildebeest).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9261371; DOI=10.1128/jvi.71.9.6517-6525.1997;
RA   Ensser A., Pflanz R., Fleckenstein B.;
RT   "Primary structure of the alcelaphine herpesvirus 1 genome.";
RL   J. Virol. 71:6517-6525(1997).
RN   [2]
RP   FUNCTION.
RX   PubMed=19031004; DOI=10.1007/s11259-008-9186-z;
RA   Leenadevi T., Dalziel R.G.;
RT   "Alcelaphine herpesvirus-1 open reading frame 57 encodes an immediate-early
RT   protein with regulatory function.";
RL   Vet. Res. Commun. 33:395-407(2009).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=19031003; DOI=10.1007/s11259-008-9187-y;
RA   Leenadevi T., Dalziel R.G.;
RT   "The alcelaphine herpesvirus-1 ORF 57 encodes a nuclear shuttling
RT   protein.";
RL   Vet. Res. Commun. 33:409-419(2009).
CC   -!- FUNCTION: Acts at a post-transcriptional level to regulate viral gene
CC       expression. {ECO:0000269|PubMed:19031004}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:19031003}. Host
CC       cytoplasm {ECO:0000269|PubMed:19031003}. Note=Shuttles between the host
CC       nucleus and cytoplasm.
CC   -!- SIMILARITY: Belongs to the herpesviridae UL69 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF005370; AAC58104.1; -; Genomic_DNA.
DR   PIR; T03152; T03152.
DR   RefSeq; NP_065556.1; NC_002531.1.
DR   SMR; O36407; -.
DR   GeneID; 911781; -.
DR   KEGG; vg:911781; -.
DR   Proteomes; UP000000941; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR008648; ICP27-like.
DR   Pfam; PF05459; Herpes_UL69; 1.
PE   3: Inferred from homology;
KW   Early protein; Host cytoplasm; Host nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..436
FT                   /note="Immediate-early phosphoprotein 57"
FT                   /id="PRO_0000405758"
FT   REGION          71..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..140
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   436 AA;  49317 MW;  B8829FF78A2CCE43 CRC64;
     MAQQAIVTMS ALRRTMEVSD SGDVSIDISA EDSNDSFHLE ESVDDCMDDC KPNNRPNPIS
     MKPAKRRVFM VPKRERSKTP VQHTSPLNRL YPNVVLGKQH GYKQRPAPSA RSRRPQPYSA
     RKDSAAKPQS TPSNQNPLTE LLKNVDPAIA SRITEMRIPR SMLRTPSGQP FAHWLMPSAE
     DSSKFINVNP VNMEVEEHVN VVVRRCTEWA LISSRLQDKS ISTKYLAENF YDLRDFAQRS
     INKSAWINLR REAIANAGFV NLCAFADEMM MWLQLNLNNQ GSWKACREDI ILTGAPDMCF
     HALQKVRAFI KCFLRERHQR ALVNALCHII CFEGGIKQAA TLCQELFFDF KVGLMVLYFL
     TPYAFLYSHT IPQCNFGGYF SKCVAQYTPG AVTGLLNSAI EDHYKDCTSQ DCTNLITAIV
     SPETSNKGLL FFPLPM