ID   IELA_ASPFC              Reviewed;          87 AA.
AC   B0XZT4;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Elastase inhibitor AFLEI;
DE   Flags: Precursor;
GN   ORFNames=AFUB_034300;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Elastase inhibitor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR   EMBL; DS499596; EDP52266.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0XZT4; -.
DR   SMR; B0XZT4; -.
DR   MEROPS; I78.001; -.
DR   EnsemblFungi; EDP52266; EDP52266; AFUB_034300.
DR   VEuPathDB; FungiDB:AFUB_034300; -.
DR   HOGENOM; CLU_2483894_0_0_1; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021719; Prot_inh_I78.
DR   Pfam; PF11720; Inhibitor_I78; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Protease inhibitor; Secreted; Serine protease inhibitor;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..87
FT                   /note="Elastase inhibitor AFLEI"
FT                   /id="PRO_0000352769"
FT   DISULFID        24..86
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   87 AA;  9413 MW;  64E569B7278F9C94 CRC64;
     MKFSLACLLA LAGLQAALAD PATCEKEAQF VKQELIGQPY TDAVANALQS NPIRVLHPGD
     MITMEYIASR LNIQVNENNE IISAHCA