APC7_ARATH
ID APC7_ARATH Reviewed; 558 AA.
AC Q8VY89; C0Z2F9; Q2V418; Q9ZUZ9;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Anaphase-promoting complex subunit 7;
DE AltName: Full=Cyclosome subunit 7;
GN Name=APC7; OrderedLocusNames=At2g39090; ORFNames=T7F6.26;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C complex controls several key steps in the cell cycle
CC by mediating ubiquitination and subsequent degradation of target
CC proteins such as cyclins. The APC/C complex is required for the female
CC gametophyte development and is involved in several aspect of
CC development by controlling cell division and cell elongation. Involved
CC in the control of endoreduplication (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 10 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8VY89-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VY89-2; Sequence=VSP_039620, VSP_039621;
CC Name=3;
CC IsoId=Q8VY89-3; Sequence=VSP_039622, VSP_039623;
CC -!- SIMILARITY: Belongs to the APC7 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC79619.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005770; AAC79619.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC09633.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09634.1; -; Genomic_DNA.
DR EMBL; AY072346; AAL61953.1; -; mRNA.
DR EMBL; BT002547; AAO00907.1; -; mRNA.
DR EMBL; AK318773; BAH56888.1; -; mRNA.
DR PIR; A84813; A84813.
DR RefSeq; NP_001031513.1; NM_001036436.1. [Q8VY89-3]
DR RefSeq; NP_850309.1; NM_179978.3. [Q8VY89-1]
DR AlphaFoldDB; Q8VY89; -.
DR SMR; Q8VY89; -.
DR BioGRID; 3833; 17.
DR IntAct; Q8VY89; 17.
DR STRING; 3702.AT2G39090.1; -.
DR iPTMnet; Q8VY89; -.
DR PaxDb; Q8VY89; -.
DR PRIDE; Q8VY89; -.
DR ProteomicsDB; 244992; -. [Q8VY89-1]
DR EnsemblPlants; AT2G39090.1; AT2G39090.1; AT2G39090. [Q8VY89-1]
DR EnsemblPlants; AT2G39090.2; AT2G39090.2; AT2G39090. [Q8VY89-3]
DR GeneID; 818495; -.
DR Gramene; AT2G39090.1; AT2G39090.1; AT2G39090. [Q8VY89-1]
DR Gramene; AT2G39090.2; AT2G39090.2; AT2G39090. [Q8VY89-3]
DR KEGG; ath:AT2G39090; -.
DR Araport; AT2G39090; -.
DR TAIR; locus:2065011; AT2G39090.
DR eggNOG; KOG1174; Eukaryota.
DR HOGENOM; CLU_026953_0_1_1; -.
DR InParanoid; Q8VY89; -.
DR OMA; YRFEVYK; -.
DR PhylomeDB; Q8VY89; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q8VY89; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8VY89; baseline and differential.
DR Genevisible; Q8VY89; AT.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell cycle; Cell division; Mitosis; Nucleus;
KW Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway.
FT CHAIN 1..558
FT /note="Anaphase-promoting complex subunit 7"
FT /id="PRO_0000396843"
FT REPEAT 43..76
FT /note="TPR 1"
FT REPEAT 138..171
FT /note="TPR 2"
FT REPEAT 212..245
FT /note="TPR 3"
FT REPEAT 246..279
FT /note="TPR 4"
FT REPEAT 314..346
FT /note="TPR 5"
FT REPEAT 348..380
FT /note="TPR 6"
FT REPEAT 381..413
FT /note="TPR 7"
FT REPEAT 414..448
FT /note="TPR 8"
FT REPEAT 450..482
FT /note="TPR 9"
FT REPEAT 483..515
FT /note="TPR 10"
FT REGION 519..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..536
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..558
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 389..405
FT /note="SYLAFGKTKEALYTARE -> EGKRSDIHFHCCTVLVV (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:19423640"
FT /id="VSP_039620"
FT VAR_SEQ 406..558
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19423640"
FT /id="VSP_039621"
FT VAR_SEQ 511..514
FT /note="INPQ -> FMKF (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_039622"
FT VAR_SEQ 515..558
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_039623"
SQ SEQUENCE 558 AA; 62346 MW; 468EFC5C58B913A6 CRC64;
MEVPKEQIAT LIEHGLYDSA EMLGCFLVSS PTVSAETSPQ LKAENLILLG DALFHQREHR
RAIHTYKQAL HHYTRIPKQS SGISRSSLSL STRSSVNASS ISAINENEVR FKIASSHFAL
NETKAAIAEM ESVKTRSLEM NILMAKLHRN SGYNRGAIAF YKECLRQCPY VLEAVIGLAE
LGVSAKDIIS SFTQTSNRSA KVSLDQIDPT RWLQRYVEAQ CCVASHAYKG ALELFAELLQ
RFPNNVHLLT ETAKVEAIIG KNDEAIMRFE KVRSIDPYTL TSMDEYAMLL QIKCDYSRLN
KLVHDLLSVD HTRAEVFVAL SVLWERKDAR TALSYAEKSI RVDERHIPGY IMKGNLLLQA
KRPEAAAIAF RAAQNLRSDL RSYQGLVHSY LAFGKTKEAL YTAREAMNAM PQSAKALKLV
GDVHAFTSSG REKAKKFYES GLRLEPGYLG AVLALAELHL MEGRNGDAVS LLERYLKDYA
DDSLHVKLAQ VFAATNMLQD SLSHFQAALR INPQNEAAKK GLDRLEKQMK GIDPDATDEN
DENDVEDVDG DTEEAELM
