ID   IEND1_NEUCR             Reviewed;         304 AA.
AC   Q36580; M1QL68;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Probable intron-encoded endonuclease 1;
DE            EC=3.1.-.-;
GN   ORFNames=NCU16019;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3003362; DOI=10.1016/0022-2836(85)90100-7;
RA   Burger G., Werner S.;
RT   "The mitochondrial URF1 gene in Neurospora crassa has an intron that
RT   contains a novel type of URF.";
RL   J. Mol. Biol. 186:231-242(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RA   Kennell J.C., Collins R.A., Griffiths A.J.F., Nargang F.E.;
RT   "Mitochondrial genetics of Neurospora.";
RL   (In) Kueck U. (eds.);
RL   The Mycota II, Genetics and Biotechnology (2nd edition), pp.95-112,
RL   Springer-Verlag, Berlin-Heidelberg (2004).
CC   -!- FUNCTION: Mitochondrial DNA endonuclease involved in intron homing.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- MISCELLANEOUS: Encoded within intron 1 of ndh-1.
CC   -!- SIMILARITY: To endonucleases of group I introns of fungi and phage.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X03280; CAA27030.1; -; Genomic_DNA.
DR   EMBL; KC683708; AGG16008.1; -; Genomic_DNA.
DR   PIR; B23431; B23431.
DR   RefSeq; YP_009126720.1; NC_026614.1.
DR   AlphaFoldDB; Q36580; -.
DR   SMR; Q36580; -.
DR   EnsemblFungi; AGG16008; AGG16008; NCU16019.
DR   GeneID; 23681574; -.
DR   KEGG; ncr:NCU16019; -.
DR   VEuPathDB; FungiDB:NCU16019; -.
DR   InParanoid; Q36580; -.
DR   Proteomes; UP000001805; Mitochondrion.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR006350; Intron_endoG1.
DR   InterPro; IPR003647; Intron_nuc_1_rpt.
DR   InterPro; IPR010896; NUMOD1.
DR   InterPro; IPR003611; NUMOD3.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF07453; NUMOD1; 1.
DR   Pfam; PF07460; NUMOD3; 2.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00497; IENR1; 1.
DR   SMART; SM00496; IENR2; 3.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR01453; grpIintron_endo; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Intron homing; Mitochondrion; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..304
FT                   /note="Probable intron-encoded endonuclease 1"
FT                   /id="PRO_0000414733"
FT   DOMAIN          84..175
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00977"
SQ   SEQUENCE   304 AA;  34881 MW;  665313CF384F7F88 CRC64;
     MIKKMKSYIN MNSTVTTLGA NYLVHTGYFN TISRLKVCTI ASYRYYSTSK SDSQSSDLPP
     VPIFTINNLN NKDSIKSSRI LLKDKGGIYS FINTVNNNQY IGSAKDFYLR LNEHLENKKS
     NIALQKAFTK YGLDKFIFCI YEYFTYESKI ISHKALTDLE TSYINRFNFD NLYNFKAIAT
     SSLGYKHTEE ARLKMVDYYK DKNNHPMFGK THTEEALGLI SKPGELNPMF GKKHSEATKA
     SMSEKKNKYP LGVGIYDLED NLILKFSNNV ELAKYLGISK VTVGKYLNSG LVYNKTYRFK
     PIQD