ID   IEND1_WICCA             Reviewed;         231 AA.
AC   Q34807;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Probable intron-encoded endonuclease 1;
DE            EC=3.1.-.-;
OS   Wickerhamomyces canadensis (Yeast) (Pichia canadensis).
OG   Mitochondrion.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Wickerhamomyces.
OX   NCBI_TaxID=1156965;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=21;
RX   PubMed=8536312; DOI=10.1007/bf00311880;
RA   Sekito T., Okamoto K., Kitano H., Yoshida K.;
RT   "The complete mitochondrial DNA sequence of Hansenula wingei reveals new
RT   characteristics of yeast mitochondria.";
RL   Curr. Genet. 28:39-53(1995).
CC   -!- FUNCTION: Endonuclease involved in mitochondrial 21S rRNA gene intron
CC       homing.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Belongs to the LAGLIDADG endonuclease family.
CC       {ECO:0000305}.
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DR   EMBL; D31785; BAA06580.2; -; Genomic_DNA.
DR   PIR; S58757; S58757.
DR   RefSeq; NP_038225.1; NC_001762.1.
DR   PDB; 6X1J; X-ray; 1.95 A; A=1-231.
DR   PDBsum; 6X1J; -.
DR   AlphaFoldDB; Q34807; -.
DR   SMR; Q34807; -.
DR   GeneID; 6457767; -.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006314; P:intron homing; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.28.10; -; 2.
DR   InterPro; IPR027434; Homing_endonucl.
DR   InterPro; IPR004860; LAGLIDADG_2.
DR   Pfam; PF03161; LAGLIDADG_2; 1.
DR   SUPFAM; SSF55608; SSF55608; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Endonuclease; Hydrolase; Intron homing; Mitochondrion;
KW   Nuclease.
FT   CHAIN           1..231
FT                   /note="Probable intron-encoded endonuclease 1"
FT                   /id="PRO_0000192786"
FT   HELIX           9..12
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           20..26
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           34..45
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   STRAND          49..51
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   STRAND          60..66
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           68..77
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           79..81
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   STRAND          87..92
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   STRAND          98..105
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           110..112
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           113..119
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           131..134
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           138..148
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   STRAND          149..152
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   STRAND          163..165
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           172..186
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   STRAND          191..195
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   STRAND          198..203
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           205..207
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           208..215
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           216..218
FT                   /evidence="ECO:0007829|PDB:6X1J"
FT   HELIX           221..226
FT                   /evidence="ECO:0007829|PDB:6X1J"
SQ   SEQUENCE   231 AA;  27809 MW;  9502442A5D212E14 CRC64;
     MMKKQIINKK DLLGLGPNSK LIKDYKKQWT TLSKIQEETL IGNILGDVYI KKLKRNKHFL
     LQFEWKNKAY IEHIVRVFDE YVISPPTLYE RKNHLGNKVI TWRAQTFEHK AFDKLGYYFM
     ENHKKIIKPD LVLNYITERS LAYWFMDDGG KWDYNKKTKN KSLVLHTQGF KKEEVEILIN
     DLNIKFNLNC SIKFNKNKPI IYIPNKDYEL FYNLVNPYII PEMKYKLLFN V