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IER2_HUMAN
ID   IER2_HUMAN              Reviewed;         223 AA.
AC   Q9BTL4; Q03827; Q2TAZ2;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Immediate early response gene 2 protein;
DE   AltName: Full=Protein ETR101;
GN   Name=IER2 {ECO:0000312|HGNC:HGNC:28871};
GN   Synonyms=ETR101 {ECO:0000303|PubMed:19584537},
GN   PIP92 {ECO:0000303|PubMed:22120713};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND VARIANT VAL-133.
RC   TISSUE=Promyelocytic leukemia;
RX   PubMed=2061303; DOI=10.1016/s0021-9258(18)98873-3;
RA   Shimizu N., Ohta M., Fujiwara C., Sagara J., Mochizuki N., Oda T.,
RA   Utlyama H.;
RT   "Expression of a novel immediate early gene during 12-O-
RT   tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-
RT   60 cells.";
RL   J. Biol. Chem. 266:12157-12161(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, Duodenum, and Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, AND DNA-BINDING.
RX   PubMed=19584537; DOI=10.1271/bbb.90162;
RA   Takaya T., Kasatani K., Noguchi S., Nikawa J.;
RT   "Functional analyses of immediate early gene ETR101 expressed in yeast.";
RL   Biosci. Biotechnol. Biochem. 73:1653-1660(2009).
RN   [6]
RP   FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX   PubMed=22120713; DOI=10.1038/onc.2011.535;
RA   Neeb A., Wallbaum S., Novac N., Dukovic-Schulze S., Scholl I.,
RA   Schreiber C., Schlag P., Moll J., Stein U., Sleeman J.P.;
RT   "The immediate early gene Ier2 promotes tumor cell motility and metastasis,
RT   and predicts poor survival of colorectal cancer patients.";
RL   Oncogene 31:3796-3806(2012).
RN   [7]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- FUNCTION: DNA-binding protein that seems to act as a transcription
CC       factor (PubMed:19584537). Involved in the regulation of neuronal
CC       differentiation, acts upon JNK-signaling pathway activation and plays a
CC       role in neurite outgrowth in hippocampal cells (By similarity). May
CC       mediate with FIBP FGF-signaling in the establishment of laterality in
CC       the embryo (By similarity). Promotes cell motility, seems to stimulate
CC       tumor metastasis (PubMed:22120713). {ECO:0000250|UniProtKB:B7SXM5,
CC       ECO:0000250|UniProtKB:Q6P7D3, ECO:0000269|PubMed:19584537,
CC       ECO:0000269|PubMed:22120713}.
CC   -!- INTERACTION:
CC       Q9BTL4; O94817: ATG12; NbExp=3; IntAct=EBI-2806011, EBI-746742;
CC       Q9BTL4; O75031: HSF2BP; NbExp=3; IntAct=EBI-2806011, EBI-7116203;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22120713}. Nucleus
CC       {ECO:0000269|PubMed:22120713}. Note=Cytoplasmic during quiescence,
CC       translocates to the nucleus upon stimulation.
CC       {ECO:0000269|PubMed:22120713}.
CC   -!- TISSUE SPECIFICITY: Expressed in activated T-cells (at protein level)
CC       (PubMed:22120713). Expression increases in metastatic tumor cells (at
CC       protein level) (PubMed:22120713). {ECO:0000269|PubMed:22120713}.
CC   -!- INDUCTION: By growth factors and 12-O-tetradecanoylphorbol-13-acetate
CC       (TPA). {ECO:0000269|PubMed:2061303}.
CC   -!- SIMILARITY: Belongs to the IER family. {ECO:0000305}.
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DR   EMBL; M62831; AAA35814.1; -; mRNA.
DR   EMBL; CR450352; CAG29348.1; -; mRNA.
DR   EMBL; BT019466; AAV38273.1; -; mRNA.
DR   EMBL; BC003625; AAH03625.1; -; mRNA.
DR   EMBL; BC072432; AAH72432.1; -; mRNA.
DR   EMBL; BC110647; AAI10648.1; -; mRNA.
DR   CCDS; CCDS12295.1; -.
DR   PIR; A40866; A40866.
DR   RefSeq; NP_004898.2; NM_004907.2.
DR   AlphaFoldDB; Q9BTL4; -.
DR   SMR; Q9BTL4; -.
DR   BioGRID; 114959; 37.
DR   IntAct; Q9BTL4; 21.
DR   STRING; 9606.ENSP00000465617; -.
DR   iPTMnet; Q9BTL4; -.
DR   PhosphoSitePlus; Q9BTL4; -.
DR   BioMuta; IER2; -.
DR   DMDM; 73920026; -.
DR   EPD; Q9BTL4; -.
DR   jPOST; Q9BTL4; -.
DR   MassIVE; Q9BTL4; -.
DR   MaxQB; Q9BTL4; -.
DR   PaxDb; Q9BTL4; -.
DR   PeptideAtlas; Q9BTL4; -.
DR   PRIDE; Q9BTL4; -.
DR   ProteomicsDB; 78996; -.
DR   Antibodypedia; 13536; 124 antibodies from 22 providers.
DR   DNASU; 9592; -.
DR   Ensembl; ENST00000292433.4; ENSP00000292433.2; ENSG00000160888.7.
DR   Ensembl; ENST00000587885.1; ENSP00000467294.1; ENSG00000160888.7.
DR   Ensembl; ENST00000588173.1; ENSP00000465617.1; ENSG00000160888.7.
DR   GeneID; 9592; -.
DR   KEGG; hsa:9592; -.
DR   MANE-Select; ENST00000292433.4; ENSP00000292433.2; NM_004907.3; NP_004898.2.
DR   UCSC; uc002mwr.4; human.
DR   CTD; 9592; -.
DR   DisGeNET; 9592; -.
DR   GeneCards; IER2; -.
DR   HGNC; HGNC:28871; IER2.
DR   HPA; ENSG00000160888; Low tissue specificity.
DR   neXtProt; NX_Q9BTL4; -.
DR   OpenTargets; ENSG00000160888; -.
DR   PharmGKB; PA134982230; -.
DR   VEuPathDB; HostDB:ENSG00000160888; -.
DR   eggNOG; ENOG502S19F; Eukaryota.
DR   GeneTree; ENSGT00900000141021; -.
DR   HOGENOM; CLU_1234685_0_0_1; -.
DR   InParanoid; Q9BTL4; -.
DR   OMA; MVMRSAR; -.
DR   OrthoDB; 1503216at2759; -.
DR   PhylomeDB; Q9BTL4; -.
DR   PathwayCommons; Q9BTL4; -.
DR   SignaLink; Q9BTL4; -.
DR   BioGRID-ORCS; 9592; 27 hits in 1078 CRISPR screens.
DR   ChiTaRS; IER2; human.
DR   GenomeRNAi; 9592; -.
DR   Pharos; Q9BTL4; Tbio.
DR   PRO; PR:Q9BTL4; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q9BTL4; protein.
DR   Bgee; ENSG00000160888; Expressed in nipple and 210 other tissues.
DR   ExpressionAtlas; Q9BTL4; baseline and differential.
DR   Genevisible; Q9BTL4; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048870; P:cell motility; IMP:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0071774; P:response to fibroblast growth factor; ISS:UniProtKB.
DR   InterPro; IPR008653; IER.
DR   PANTHER; PTHR15895; PTHR15895; 1.
DR   Pfam; PF05760; IER; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..223
FT                   /note="Immediate early response gene 2 protein"
FT                   /id="PRO_0000190435"
FT   REGION          63..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..155
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0007744|PubMed:22814378"
FT   VARIANT         133
FT                   /note="A -> V (in dbSNP:rs1042164)"
FT                   /evidence="ECO:0000269|PubMed:2061303"
FT                   /id="VAR_057581"
FT   CONFLICT        165
FT                   /note="A -> G (in Ref. 1; AAA35814)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   223 AA;  24196 MW;  CDC40214CCE0C2EE CRC64;
     MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA KVEALEPEVS
     LPAALPSDPR LHPPREAEST AETATPDGEH PFPEPMDTQE APTAEETSAC CAPRPAKVSR
     KRRSSSLSDG GDAGLVPSKK ARLEEKEEEE GASSEVADRL QPPPAQAEGA FPNLARVLQR
     RFSGLLNCSP AAPPTAPPAC EAKPACRPAD SMLNVLVRAV VAF
 
 
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