ID   IER2_RAT                Reviewed;         221 AA.
AC   Q6P7D3;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Immediate early response gene 2 protein;
GN   Name=Ier2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   FUNCTION, AND INDUCTION BY FGF.
RX   PubMed=17156131; DOI=10.1111/j.1471-4159.2006.04263.x;
RA   Park J.B., Kim E.J., Yang E.J., Seo S.R., Chung K.C.;
RT   "JNK- and Rac1-dependent induction of immediate early gene pip92 suppresses
RT   neuronal differentiation.";
RL   J. Neurochem. 100:555-566(2007).
CC   -!- FUNCTION: DNA-binding protein that seems to act as a transcription
CC       factor (By similarity). Involved in the regulation of neuronal
CC       differentiation, acts upon JNK-signaling pathway activation and plays a
CC       role in neurite outgrowth in hippocampal cells (PubMed:17156131). May
CC       mediate with FIBP FGF-signaling in the establishment of laterality in
CC       the embryo (By similarity). Promotes cell motility, seems to stimulate
CC       tumor metastasis (By similarity). {ECO:0000250|UniProtKB:B7SXM5,
CC       ECO:0000250|UniProtKB:Q9BTL4, ECO:0000269|PubMed:17156131}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BTL4}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9BTL4}. Note=Cytoplasmic during quiescence,
CC       translocates to the nucleus upon stimulation.
CC       {ECO:0000250|UniProtKB:Q9BTL4}.
CC   -!- INDUCTION: Induced by basic fibroblast growth factor (bFGF).
CC       {ECO:0000269|PubMed:17156131}.
CC   -!- SIMILARITY: Belongs to the IER family. {ECO:0000305}.
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DR   EMBL; BC061717; AAH61717.1; -; mRNA.
DR   RefSeq; NP_001009541.1; NM_001009541.1.
DR   AlphaFoldDB; Q6P7D3; -.
DR   SMR; Q6P7D3; -.
DR   STRING; 10116.ENSRNOP00000067493; -.
DR   PaxDb; Q6P7D3; -.
DR   Ensembl; ENSRNOT00000116299; ENSRNOP00000090794; ENSRNOG00000067274.
DR   GeneID; 494344; -.
DR   KEGG; rno:494344; -.
DR   CTD; 9592; -.
DR   RGD; 1359581; Ier2.
DR   eggNOG; ENOG502S19F; Eukaryota.
DR   GeneTree; ENSGT00900000141021; -.
DR   InParanoid; Q6P7D3; -.
DR   OrthoDB; 1503216at2759; -.
DR   PhylomeDB; Q6P7D3; -.
DR   TreeFam; TF331376; -.
DR   PRO; PR:Q6P7D3; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048870; P:cell motility; ISS:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; IDA:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0071774; P:response to fibroblast growth factor; IDA:UniProtKB.
DR   InterPro; IPR008653; IER.
DR   PANTHER; PTHR15895; PTHR15895; 1.
DR   Pfam; PF05760; IER; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..221
FT                   /note="Immediate early response gene 2 protein"
FT                   /id="PRO_0000190437"
FT   REGION          54..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTL4"
SQ   SEQUENCE   221 AA;  24596 MW;  48E69A05D18BB945 CRC64;
     MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA KVETHQPEFP
     PSRRALDPRL HPPREPEAAM EAATPDVEQP PEPMDTQEEV LRVQETPALC DPPPARVSRK
     RRSSSDLSDG SDAGLVPSKK ARLEEVEGEA TSEVSNRLQL PPAQTEGAFP NLARVLQRRF
     SSLLNCGPAV PPPTPPTCEA KPACRPADNM LNVLVRTVVA F