IER5L_HUMAN
ID IER5L_HUMAN Reviewed; 404 AA.
AC Q5T953; Q6P3E2;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Immediate early response gene 5-like protein;
GN Name=IER5L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-105.
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T953-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T953-2; Sequence=VSP_033726, VSP_033727;
CC -!- SIMILARITY: Belongs to the IER family. {ECO:0000305}.
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DR EMBL; AL158151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471090; EAW87886.1; -; Genomic_DNA.
DR EMBL; BC064028; AAH64028.1; -; mRNA.
DR CCDS; CCDS43888.1; -. [Q5T953-1]
DR RefSeq; NP_982258.2; NM_203434.2. [Q5T953-1]
DR AlphaFoldDB; Q5T953; -.
DR SMR; Q5T953; -.
DR BioGRID; 133275; 6.
DR STRING; 9606.ENSP00000361569; -.
DR iPTMnet; Q5T953; -.
DR PhosphoSitePlus; Q5T953; -.
DR BioMuta; IER5L; -.
DR DMDM; 74745628; -.
DR EPD; Q5T953; -.
DR MassIVE; Q5T953; -.
DR MaxQB; Q5T953; -.
DR PaxDb; Q5T953; -.
DR PeptideAtlas; Q5T953; -.
DR PRIDE; Q5T953; -.
DR ProteomicsDB; 64775; -. [Q5T953-1]
DR ProteomicsDB; 64776; -. [Q5T953-2]
DR Antibodypedia; 7862; 46 antibodies from 14 providers.
DR DNASU; 389792; -.
DR Ensembl; ENST00000372491.4; ENSP00000361569.2; ENSG00000188483.8. [Q5T953-1]
DR GeneID; 389792; -.
DR KEGG; hsa:389792; -.
DR MANE-Select; ENST00000372491.4; ENSP00000361569.2; NM_203434.3; NP_982258.2.
DR UCSC; uc010myt.2; human. [Q5T953-1]
DR CTD; 389792; -.
DR DisGeNET; 389792; -.
DR GeneCards; IER5L; -.
DR HGNC; HGNC:23679; IER5L.
DR HPA; ENSG00000188483; Low tissue specificity.
DR neXtProt; NX_Q5T953; -.
DR OpenTargets; ENSG00000188483; -.
DR PharmGKB; PA134879111; -.
DR VEuPathDB; HostDB:ENSG00000188483; -.
DR eggNOG; ENOG502QUU4; Eukaryota.
DR GeneTree; ENSGT00900000141021; -.
DR HOGENOM; CLU_057338_1_1_1; -.
DR InParanoid; Q5T953; -.
DR OMA; QDCCCDA; -.
DR OrthoDB; 928914at2759; -.
DR PhylomeDB; Q5T953; -.
DR TreeFam; TF331376; -.
DR PathwayCommons; Q5T953; -.
DR BioGRID-ORCS; 389792; 28 hits in 1079 CRISPR screens.
DR ChiTaRS; IER5L; human.
DR GenomeRNAi; 389792; -.
DR Pharos; Q5T953; Tdark.
DR PRO; PR:Q5T953; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q5T953; protein.
DR Bgee; ENSG00000188483; Expressed in vena cava and 151 other tissues.
DR Genevisible; Q5T953; HS.
DR InterPro; IPR008653; IER.
DR PANTHER; PTHR15895; PTHR15895; 1.
DR Pfam; PF05760; IER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..404
FT /note="Immediate early response gene 5-like protein"
FT /id="PRO_0000334656"
FT REGION 86..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 308..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 212..237
FT /note="PGAAPPAAAASPPASPAPASSPGFYR -> RSPPASAPASRTSARTRPRTRP
FT TSQT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_033726"
FT VAR_SEQ 238..404
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_033727"
FT VARIANT 105
FT /note="P -> S (in dbSNP:rs184457)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_043450"
SQ SEQUENCE 404 AA; 42109 MW; 72EF41BE313DEFB0 CRC64;
MECALDAQSL ISISLRKIHS SRTQRGGIKL HKNLLVSYVL RNARQLYLSE RYAELYRRQQ
QQQQQQPPHH QHQHLAYAAP GMPASAADFG PLQLGGGGDA EAREPAARHQ LHQLHQLHQL
HLQQQLHQHQ HPAPRGCAAA AAAGAPAGGA GALSELPGCA ALQPPHGAPH RGQPLEPLQP
GPAPLPLPLP PPAPAALCPR DPRAPAACSA PPGAAPPAAA ASPPASPAPA SSPGFYRGAY
PTPSDFGLHC SSQTTVLDLD THVVTTVENG YLHQDCCASA HCPCCGQGAP GPGLASAAGC
KRKYYPGQEE EEDDEEDAGG LGAEPPGGAP FAPCKRARFE DFCPDSSPDA SNISNLISIF
GSGFSGLVSR QPDSSEQPPP LNGQLCAKQA LASLGAWTRA IVAF
