IER5L_MOUSE
ID IER5L_MOUSE Reviewed; 406 AA.
AC Q99J55; Q8BTA0; Q8CC26;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Immediate early response gene 5-like protein;
GN Name=Ier5l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the IER family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25357.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC28563.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK012145; BAC25357.1; ALT_FRAME; mRNA.
DR EMBL; AK034055; BAC28563.1; ALT_FRAME; mRNA.
DR EMBL; AL954299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003464; AAH03464.1; -; mRNA.
DR EMBL; BC010234; AAH10234.1; -; mRNA.
DR EMBL; BC040084; AAH40084.1; -; mRNA.
DR CCDS; CCDS38095.1; -.
DR RefSeq; NP_084520.3; NM_030244.3.
DR AlphaFoldDB; Q99J55; -.
DR SMR; Q99J55; -.
DR STRING; 10090.ENSMUSP00000132594; -.
DR PhosphoSitePlus; Q99J55; -.
DR PaxDb; Q99J55; -.
DR PRIDE; Q99J55; -.
DR Antibodypedia; 7862; 46 antibodies from 14 providers.
DR Ensembl; ENSMUST00000065134; ENSMUSP00000132594; ENSMUSG00000089762.
DR GeneID; 72500; -.
DR KEGG; mmu:72500; -.
DR UCSC; uc008jco.1; mouse.
DR CTD; 389792; -.
DR MGI; MGI:1919750; Ier5l.
DR VEuPathDB; HostDB:ENSMUSG00000089762; -.
DR eggNOG; ENOG502QUU4; Eukaryota.
DR GeneTree; ENSGT00900000141021; -.
DR HOGENOM; CLU_057338_1_1_1; -.
DR InParanoid; Q99J55; -.
DR OMA; QDCCCDA; -.
DR OrthoDB; 928914at2759; -.
DR PhylomeDB; Q99J55; -.
DR TreeFam; TF331376; -.
DR BioGRID-ORCS; 72500; 6 hits in 75 CRISPR screens.
DR ChiTaRS; Ier5l; mouse.
DR PRO; PR:Q99J55; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q99J55; protein.
DR Bgee; ENSMUSG00000089762; Expressed in cerebellum ventricular layer and 163 other tissues.
DR Genevisible; Q99J55; MM.
DR InterPro; IPR008653; IER.
DR PANTHER; PTHR15895; PTHR15895; 1.
DR Pfam; PF05760; IER; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..406
FT /note="Immediate early response gene 5-like protein"
FT /id="PRO_0000334657"
FT REGION 166..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 160..161
FT /note="PG -> RR (in Ref. 1; BAC25357)"
FT /evidence="ECO:0000305"
FT CONFLICT 279
FT /note="C -> L (in Ref. 1; BAC25357)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 406 AA; 42530 MW; 0A0A6722F7923DC5 CRC64;
MECALDAQSL ISISLRKIHS SRTQRGGIKL HKNLLVSYVL RNARQLYLSE RYAELYRRQQ
QQQQQQPPHH QHQHLAYAAP GMPASAADFG PLQLGGGGDA EAREPVARHQ LHQLHQLHQL
HLQQQLHQHQ HPAPRGCTAA APVAVAGAPA GCAGALSELP GCAALQPPHG APHRGQHLEP
LQPGPAPLPP PAPAALCPRD PRVPAACSAP SVLPGAAPST VAASSPPAST APSSSTGFYR
GAYPAPSDFG VHCSSQTTVL DLDTHVVTTV ENGYLHQDCC ASAHCPCCGQ GAPGPGLASA
AGCKRKYYPG QEEEDDEEDA GDLGAEPPGG TPFAPCKRAR FEDFCPDSSP DASNISNLIS
IFGSGFSGLV SRQPDSSEQP PPLNGQLCAK QALASLGAWT RAIVAF
