IES2_SCHPO
ID IES2_SCHPO Reviewed; 295 AA.
AC O14210;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=INO80 complex subunit 2;
GN Name=ies2; ORFNames=SPAC6B12.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Component of the INO80 complex which remodels chromatin by
CC shifting nucleosomes and is involved in DNA repair. {ECO:0000250}.
CC -!- SUBUNIT: Component of the INO80 chromatin remodeling complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the IES2 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11067.1; -; Genomic_DNA.
DR PIR; T39012; T39012.
DR RefSeq; NP_593760.1; NM_001019190.2.
DR AlphaFoldDB; O14210; -.
DR SMR; O14210; -.
DR BioGRID; 279654; 74.
DR STRING; 4896.SPAC6B12.05c.1; -.
DR iPTMnet; O14210; -.
DR MaxQB; O14210; -.
DR PaxDb; O14210; -.
DR PRIDE; O14210; -.
DR EnsemblFungi; SPAC6B12.05c.1; SPAC6B12.05c.1:pep; SPAC6B12.05c.
DR GeneID; 2543226; -.
DR KEGG; spo:SPAC6B12.05c; -.
DR PomBase; SPAC6B12.05c; ies2.
DR VEuPathDB; FungiDB:SPAC6B12.05c; -.
DR eggNOG; ENOG502S7M7; Eukaryota.
DR HOGENOM; CLU_943846_0_0_1; -.
DR InParanoid; O14210; -.
DR OMA; MYRWIST; -.
DR PhylomeDB; O14210; -.
DR PRO; PR:O14210; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031011; C:Ino80 complex; IPI:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034080; P:CENP-A containing chromatin assembly; IMP:PomBase.
DR GO; GO:0006338; P:chromatin remodeling; IDA:PomBase.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0071931; P:positive regulation of transcription involved in G1/S transition of mitotic cell cycle; IMP:PomBase.
DR InterPro; IPR029523; INO80B/Ies2.
DR InterPro; IPR006880; INO80B_C.
DR PANTHER; PTHR21561; PTHR21561; 1.
DR Pfam; PF04795; PAPA-1; 1.
DR SMART; SM01406; PAPA-1; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; DNA damage; DNA repair; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..295
FT /note="INO80 complex subunit 2"
FT /id="PRO_0000116664"
FT REGION 1..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..93
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 295 AA; 33536 MW; 79EC066E29822ACB CRC64;
MARRRSTRRA LVETPSDLNA QDSDSLSVST KEELGDDALA AEEGQSVLDE QEIEEALEED
DTNYEEDIID DEESAQVDEE ELEEEEEEEE DATPEPVVTS KKNSRSKPKN GGASKRKASR
RTVVDEDSEN LEGDEEDGSF SDLKDLYSNP MPAQTTPVSM RMTKRQRAIQ GILEEGEEDE
LLELPPETSG RKKLTPEEMA LRRIENARRR KNQSERRLEE EKMETINRLL KRQSNTGKPR
RGRAPNNPTS DSISRSKAVP KDRINMYQPF QCVRFKSTKE GSSLGVPEPL IRFFS
