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IES3_YEAST
ID   IES3_YEAST              Reviewed;         250 AA.
AC   Q12345; D6VY54;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 150.
DE   RecName: Full=Ino eighty subunit 3;
GN   Name=IES3; OrderedLocusNames=YLR052W; ORFNames=L2131;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   PARTIAL PROTEIN SEQUENCE, AND IDENTIFICATION IN THE INO80 COMPLEX.
RX   PubMed=12887900; DOI=10.1016/s1097-2765(03)00264-8;
RA   Shen X., Ranallo R., Choi E., Wu C.;
RT   "Involvement of actin-related proteins in ATP-dependent chromatin
RT   remodeling.";
RL   Mol. Cell 12:147-155(2003).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-211, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- FUNCTION: Probably involved in transcription regulation via its
CC       interaction with the INO80 complex, a chromatin-remodeling complex.
CC   -!- SUBUNIT: Component of the chromatin-remodeling INO80 complex, at least
CC       composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3,
CC       IES4, IES6, ACT1, IES2, IES5 and INO80. {ECO:0000269|PubMed:12887900}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 2300 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z73224; CAA97582.1; -; Genomic_DNA.
DR   EMBL; X94607; CAA64299.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09370.1; -; Genomic_DNA.
DR   PIR; S61626; S61626.
DR   RefSeq; NP_013153.1; NM_001181939.1.
DR   AlphaFoldDB; Q12345; -.
DR   SMR; Q12345; -.
DR   BioGRID; 31327; 380.
DR   ComplexPortal; CPX-863; INO80 chromatin remodeling complex.
DR   DIP; DIP-4830N; -.
DR   IntAct; Q12345; 42.
DR   MINT; Q12345; -.
DR   STRING; 4932.YLR052W; -.
DR   iPTMnet; Q12345; -.
DR   MaxQB; Q12345; -.
DR   PaxDb; Q12345; -.
DR   PRIDE; Q12345; -.
DR   EnsemblFungi; YLR052W_mRNA; YLR052W; YLR052W.
DR   GeneID; 850741; -.
DR   KEGG; sce:YLR052W; -.
DR   SGD; S000004042; IES3.
DR   VEuPathDB; FungiDB:YLR052W; -.
DR   eggNOG; ENOG502S125; Eukaryota.
DR   HOGENOM; CLU_105947_0_0_1; -.
DR   InParanoid; Q12345; -.
DR   OMA; KINYEMV; -.
DR   BioCyc; YEAST:G3O-32208-MON; -.
DR   PRO; PR:Q12345; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q12345; protein.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR   GO; GO:0031011; C:Ino80 complex; IDA:SGD.
DR   GO; GO:0005634; C:nucleus; IDA:ComplexPortal.
DR   GO; GO:0006338; P:chromatin remodeling; IDA:SGD.
DR   GO; GO:0006281; P:DNA repair; IC:ComplexPortal.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IC:ComplexPortal.
DR   GO; GO:0031509; P:subtelomeric heterochromatin assembly; IMP:SGD.
DR   GO; GO:0000723; P:telomere maintenance; IMP:SGD.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IGI:SGD.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..250
FT                   /note="Ino eighty subunit 3"
FT                   /id="PRO_0000084155"
FT   REGION          29..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..44
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        45..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         157
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:18407956"
FT   MOD_RES         211
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19779198"
SQ   SEQUENCE   250 AA;  28243 MW;  5A0A2229D6C87ABF CRC64;
     MKFEDLLATN KQVQFAHAAT QHYKSVKTPD FLEKDPHHKK FHNADGLNQQ GSSTPSTATD
     ANAASTASTH TNTTTFKRHI VAVDDISKMN YEMIKNSPGN VITNANQDEI DISTLKTRLY
     KDNLYAMNDN FLQAVNDQIV TLNAAEQDQE TEDPDLSDDE KIDILTKIQE NLLEEYQKLS
     QKERKWFILK ELLLDANVEL DLFSNRGRKA SHPIAFGAVA IPTNVNANSL AFNRTKRRKI
     NKNGLLENIL
 
 
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