IES6_YEAST
ID IES6_YEAST Reviewed; 166 AA.
AC P32617; D3DLK5; Q6Q5Q5;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Chromatin-remodeling complex subunit IES6;
DE AltName: Full=Ino eighty subunit 6;
GN Name=IES6; OrderedLocusNames=YEL044W; ORFNames=SYGP-ORF13;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169868;
RA Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA Botstein D., Davis R.W.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL Nature 387:78-81(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP IDENTIFICATION IN THE INO80 COMPLEX, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=12887900; DOI=10.1016/s1097-2765(03)00264-8;
RA Shen X., Ranallo R., Choi E., Wu C.;
RT "Involvement of actin-related proteins in ATP-dependent chromatin
RT remodeling.";
RL Mol. Cell 12:147-155(2003).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP FUNCTION OF THE INO80 COMPLEX.
RX PubMed=15607974; DOI=10.1016/j.cell.2004.11.037;
RA Morrison A.J., Highland J., Krogan N.J., Arbel-Eden A., Greenblatt J.F.,
RA Haber J.E., Shen X.;
RT "INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling
RT to DNA damage repair.";
RL Cell 119:767-775(2004).
RN [8]
RP FUNCTION.
RX PubMed=15184655; DOI=10.1073/pnas.0403093101;
RA Smith S., Hwang J.-Y., Banerjee S., Majeed A., Gupta A., Myung K.;
RT "Mutator genes for suppression of gross chromosomal rearrangements
RT identified by a genome-wide screening in Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9039-9044(2004).
RN [9]
RP FUNCTION.
RX PubMed=17562861; DOI=10.1128/mcb.00418-07;
RA Yu E.Y., Steinberg-Neifach O., Dandjinou A.T., Kang F., Morrison A.J.,
RA Shen X., Lue N.F.;
RT "Regulation of telomere structure and functions by subunits of the INO80
RT chromatin remodeling complex.";
RL Mol. Cell. Biol. 27:5639-5649(2007).
CC -!- FUNCTION: Probably involved in transcription regulation via its
CC interaction with the INO80 complex, a chromatin remodeling complex.
CC Also involved in the regulation of telomere length.
CC {ECO:0000269|PubMed:15184655, ECO:0000269|PubMed:15607974,
CC ECO:0000269|PubMed:17562861}.
CC -!- SUBUNIT: Component of the chromatin-remodeling INO80 complex, at least
CC composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3,
CC IES4, IES6, ACT1, IES2, IES5 and INO80. {ECO:0000269|PubMed:12887900}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 1720 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the IES6 family. {ECO:0000305}.
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DR EMBL; U18779; AAB64998.1; -; Genomic_DNA.
DR EMBL; AY557805; AAS56131.1; -; Genomic_DNA.
DR EMBL; BK006939; DAA07609.1; -; Genomic_DNA.
DR PIR; S30833; S30833.
DR RefSeq; NP_010870.1; NM_001178859.1.
DR AlphaFoldDB; P32617; -.
DR BioGRID; 36685; 48.
DR ComplexPortal; CPX-863; INO80 chromatin remodeling complex.
DR IntAct; P32617; 4.
DR MINT; P32617; -.
DR STRING; 4932.YEL044W; -.
DR iPTMnet; P32617; -.
DR MaxQB; P32617; -.
DR PaxDb; P32617; -.
DR PRIDE; P32617; -.
DR EnsemblFungi; YEL044W_mRNA; YEL044W; YEL044W.
DR GeneID; 856667; -.
DR KEGG; sce:YEL044W; -.
DR SGD; S000000770; IES6.
DR VEuPathDB; FungiDB:YEL044W; -.
DR eggNOG; KOG4137; Eukaryota.
DR GeneTree; ENSGT00390000014303; -.
DR HOGENOM; CLU_071116_2_1_1; -.
DR InParanoid; P32617; -.
DR OMA; LRFHDKS; -.
DR BioCyc; YEAST:G3O-30164-MON; -.
DR PRO; PR:P32617; -.
DR Proteomes; UP000002311; Chromosome V.
DR RNAct; P32617; protein.
DR GO; GO:0031011; C:Ino80 complex; IPI:SGD.
DR GO; GO:0005634; C:nucleus; IDA:ComplexPortal.
DR GO; GO:0006338; P:chromatin remodeling; IDA:ComplexPortal.
DR GO; GO:0006281; P:DNA repair; IC:ComplexPortal.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IC:ComplexPortal.
DR InterPro; IPR029525; INO80C/Ies6.
DR InterPro; IPR013272; Vps72/YL1_C.
DR PANTHER; PTHR31200; PTHR31200; 1.
DR Pfam; PF08265; YL1_C; 1.
DR SMART; SM00993; YL1_C; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..166
FT /note="Chromatin-remodeling complex subunit IES6"
FT /id="PRO_0000084158"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 32
FT /note="F -> I (in Ref. 3; AAS56131)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 166 AA; 18533 MW; 4B074DB4B10DC044 CRC64;
MSGSRGNSSN SSVSNNSNNN NNNDGGDERL LFLRSVGERN EIGFPSRFKS AHYKKPTRRH
KSARQLISDE NKRINALLTK ANKAAESSTA ARRLVPKATY FSVEAPPSIR PAKKYCDVTG
LKGFYKSPTN NIRYHNAEIY QLIVKPMAPG VDQEYLKLRG ANFVLK
