ID   IF122_XENTR             Reviewed;        1189 AA.
AC   A8WGF4;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Intraflagellar transport protein 122 homolog;
GN   Name=ift122;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for cilia formation during embryonal development.
CC       Acts as a negative regulator of Shh signaling.
CC       {ECO:0000250|UniProtKB:Q9HBG6}.
CC   -!- SUBUNIT: Component of the IFT complex A (IFT-A) complex.
CC       {ECO:0000250|UniProtKB:Q9HBG6}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9HBG6}. Cytoplasm, cytoskeleton, cilium basal
CC       body {ECO:0000250|UniProtKB:Q9HBG6}.
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DR   EMBL; BC154689; AAI54690.1; -; mRNA.
DR   RefSeq; NP_001106492.1; NM_001113021.1.
DR   AlphaFoldDB; A8WGF4; -.
DR   SMR; A8WGF4; -.
DR   STRING; 8364.ENSXETP00000003079; -.
DR   PaxDb; A8WGF4; -.
DR   PRIDE; A8WGF4; -.
DR   DNASU; 100127681; -.
DR   Ensembl; ENSXETT00000070313; ENSXETP00000095267; ENSXETG00000001463.
DR   GeneID; 100127681; -.
DR   KEGG; xtr:100127681; -.
DR   CTD; 55764; -.
DR   Xenbase; XB-GENE-966865; ift122.
DR   eggNOG; KOG1538; Eukaryota.
DR   InParanoid; A8WGF4; -.
DR   OrthoDB; 449704at2759; -.
DR   Reactome; R-XTR-5610787; Hedgehog 'off' state.
DR   Reactome; R-XTR-5620924; Intraflagellar transport.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000001463; Expressed in 2-cell stage embryo and 13 other tissues.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030991; C:intraciliary transport particle A; ISS:UniProtKB.
DR   GO; GO:0097730; C:non-motile cilium; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0035721; P:intraciliary retrograde transport; ISS:UniProtKB.
DR   GO; GO:0042073; P:intraciliary transport; ISS:UniProtKB.
DR   GO; GO:0045879; P:negative regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR   GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR039857; Ift122.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12764; PTHR12764; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Developmental protein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1189
FT                   /note="Intraflagellar transport protein 122 homolog"
FT                   /id="PRO_0000398818"
FT   REPEAT          16..54
FT                   /note="WD 1"
FT   REPEAT          57..97
FT                   /note="WD 2"
FT   REPEAT          99..135
FT                   /note="WD 3"
FT   REPEAT          137..175
FT                   /note="WD 4"
FT   REPEAT          180..223
FT                   /note="WD 5"
FT   REPEAT          225..264
FT                   /note="WD 6"
FT   REPEAT          266..306
FT                   /note="WD 7"
FT   REPEAT          459..498
FT                   /note="WD 8"
SQ   SEQUENCE   1189 AA;  136443 MW;  318CFBD27C611FE9 CRC64;
     MRAVPTWVDK VHDRDKLEQS IYDLAFKPDG TQLIVAAGNR VLVYDTSDGT MIQPLKGHKD
     TVYCVAYAKD GKRFASGSAD KSVIIWTSKL EGILKYTHND SIQCVSYNPV THQLASCSSS
     DFGLWSPEQK SVSKHKVSSK ITCCSWTNDG QYLALGMFNG VVSIRNKNGE EKVKIERPGG
     ALSPIWSICW NPSKDDHNDI LAVADWGQKL SFYQLSGKQV GKDRVLGFDP CCVSYFSKGE
     YIIVSGSDKQ VSLFTKDGVR LGPIGEQNSW VWTCRVKPDS NYVVIGCQDG TLAFYQLIFS
     TVHGLYKDRY AYRDSMTDVI VQHLITEQKV RIKCRELVKK IAIYKNRLAI QMPEKILIYE
     LFSDDVNDMH YRVKEKIVKK FECNLLVVCS HHIILCQEKR LQCLSFKGVK EREWMMESLI
     RYIKVIGGPA GREGLLVGLK NGQILKIFVD NPFAITLLKQ ATSVRCLDMS ASRNKLAVVD
     EHNTCLVYDI TTKDLLFQEP NANSVAWNTQ CEDMLCFSGG GYLNIKASNF PVHQQKLQGF
     VVGYNGSKIF CLHVYSMSAV EVPQSAPMYQ YLERKMFREA YQIACLGVTD LDWKELAMEA
     LEGLDFETAK KAFIRVRDLR YLELINSIEE RKKRGDANDN LFLADVFAYQ GKFHEAAKLY
     KKAGQESRAL DMYTDLRMFE FAKEFLGSGD PKDTKTLITK QADWARNIRE PRTAAEMYLS
     AGENMKAIEL SGDHGWVDML IEIARKLDKA EREPLLKCAY YFKKLQHHGY AAETYMKIGD
     LKALVRLYVE TQRWEEAFAL VEKNPEYKDE VYIPYAQWLA EHDRFEEAQK AFHKAGRQDE
     AVRVLEQLTH NAVVESRFND AAYYYWMLSM QCLEISKDKE EKQDAMLQKF YHFQHLAELY
     HVYHSIHRYT DEPFSSHLPE TLFNISRFLL HSLTKESPLG ISKVNTLFTL AKQSKALGAY
     KLARQVYERL QGLRIPSRFL ESIELGSITI RSKPFHDSEE LIPMCYRCST NNPFLNNLGN
     VCINCRQRFV FSASSYEVLP LVEFYLEDGI SDEEAVSLVD LEAPRSSSKA DSWREMSSGD
     TQTLRLDDGD DMMTYDPFTA KLSFEQGGSE FVPVVVNRAV LRTMSRRDVL IKRWPLPLKW
     QYFRSLLPDV SITMCPSCFQ MFHTEDYELL VLQHNCCPYC RRPIEESSQ