IF172_MOUSE
ID IF172_MOUSE Reviewed; 1749 AA.
AC Q6VH22; Q6NZK1; Q80TI4; Q80W19; Q9DAB0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Intraflagellar transport protein 172 homolog;
DE AltName: Full=Protein wimple;
GN Name=Ift172; Synonyms=Kiaa1179, Wim;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND MUTAGENESIS OF
RP LEU-1564.
RC STRAIN=C57BL/6J;
RX PubMed=14603322; DOI=10.1038/nature02061;
RA Huangfu D., Liu A., Rakeman A.S., Murcia N.S., Niswander L., Anderson K.V.;
RT "Hedgehog signalling in the mouse requires intraflagellar transport
RT proteins.";
RL Nature 426:83-87(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 660-1749 (ISOFORM 1).
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [5]
RP INTERACTION WITH IFT88.
RX PubMed=11062270; DOI=10.1083/jcb.151.3.709;
RA Pazour G.J., Dickert B.L., Vucica Y., Seeley E.S., Rosenbaum J.L.,
RA Witman G.B., Cole D.G.;
RT "Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease
RT gene tg737, are required for assembly of cilia and flagella.";
RL J. Cell Biol. 151:709-718(2000).
RN [6]
RP FUNCTION.
RX PubMed=16061793; DOI=10.1073/pnas.0505328102;
RA Huangfu D., Anderson K.V.;
RT "Cilia and Hedgehog responsiveness in the mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:11325-11330(2005).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [8]
RP INTERACTION WITH RABL2, AND TISSUE SPECIFICITY.
RX PubMed=23055941; DOI=10.1371/journal.pgen.1002969;
RA Lo J.C., Jamsai D., O'Connor A.E., Borg C., Clark B.J., Whisstock J.C.,
RA Field M.C., Adams V., Ishikawa T., Aitken R.J., Whittle B., Goodnow C.C.,
RA Ormandy C.J., O'Bryan M.K.;
RT "RAB-like 2 has an essential role in male fertility, sperm intra-flagellar
RT transport, and tail assembly.";
RL PLoS Genet. 8:E1002969-E1002969(2012).
RN [9]
RP INTERACTION WITH IFT57.
RX PubMed=23810713; DOI=10.1016/j.yexcr.2013.06.010;
RA Howard P.W., Jue S.F., Maurer R.A.;
RT "Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport
RT complex B proteins and KIF17.";
RL Exp. Cell Res. 319:2275-2281(2013).
RN [10]
RP TISSUE SPECIFICITY.
RX PubMed=24339785; DOI=10.1371/journal.pgen.1003960;
RA Kraehling A.M., Alvarez L., Debowski K., Van Q., Gunkel M., Irsen S.,
RA Al-Amoudi A., Struenker T., Kremmer E., Krause E., Voigt I., Woertge S.,
RA Waisman A., Weyand I., Seifert R., Kaupp U.B., Wachten D.;
RT "CRIS-a novel cAMP-binding protein controlling spermiogenesis and the
RT development of flagellar bending.";
RL PLoS Genet. 9:E1003960-E1003960(2013).
RN [11]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-672, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Required for the maintenance and formation of cilia. Plays an
CC indirect role in hedgehog (Hh) signaling, cilia being required for all
CC activity of the hedgehog pathway. {ECO:0000269|PubMed:14603322,
CC ECO:0000269|PubMed:16061793}.
CC -!- SUBUNIT: Interacts with IFT88 (PubMed:11062270). Interacts with IFT57
CC (PubMed:23810713). Interacts with RABL2/RABL2A; binds preferentially to
CC GDP-bound RABL2 (PubMed:23055941). {ECO:0000269|PubMed:11062270,
CC ECO:0000269|PubMed:23055941, ECO:0000269|PubMed:23810713}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6VH22-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6VH22-2; Sequence=VSP_032850;
CC -!- TISSUE SPECIFICITY: Co-localizes with RABL2/RABL2A in the midpiece of
CC elongated spermatids within the testis (at protein level). Expressed in
CC the flagellum of elongated spermatids and sperm in the testis lumen (at
CC protein level) (PubMed:24339785). {ECO:0000269|PubMed:23055941,
CC ECO:0000269|PubMed:24339785}.
CC -!- SIMILARITY: Belongs to the IFT172 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC65743.3; Type=Miscellaneous discrepancy; Note=Intron retention. The sequence is a pre-RNA and intronic sequences remain.; Evidence={ECO:0000305};
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DR EMBL; AY339616; AAR05390.1; -; mRNA.
DR EMBL; AK006007; BAB24362.1; -; mRNA.
DR EMBL; BC051928; AAH51928.1; -; mRNA.
DR EMBL; BC060948; AAH60948.1; -; mRNA.
DR EMBL; BC066096; AAH66096.1; -; mRNA.
DR EMBL; AK122461; BAC65743.3; ALT_SEQ; Transcribed_RNA.
DR CCDS; CCDS39054.1; -. [Q6VH22-1]
DR RefSeq; NP_080574.5; NM_026298.5. [Q6VH22-1]
DR AlphaFoldDB; Q6VH22; -.
DR BioGRID; 212346; 5.
DR ComplexPortal; CPX-5028; IFT-B complex.
DR IntAct; Q6VH22; 1.
DR MINT; Q6VH22; -.
DR STRING; 10090.ENSMUSP00000049335; -.
DR iPTMnet; Q6VH22; -.
DR PhosphoSitePlus; Q6VH22; -.
DR EPD; Q6VH22; -.
DR MaxQB; Q6VH22; -.
DR PaxDb; Q6VH22; -.
DR PeptideAtlas; Q6VH22; -.
DR PRIDE; Q6VH22; -.
DR ProteomicsDB; 267193; -. [Q6VH22-1]
DR ProteomicsDB; 267194; -. [Q6VH22-2]
DR Antibodypedia; 28528; 99 antibodies from 20 providers.
DR DNASU; 67661; -.
DR Ensembl; ENSMUST00000041565; ENSMUSP00000049335; ENSMUSG00000038564. [Q6VH22-1]
DR GeneID; 67661; -.
DR KEGG; mmu:67661; -.
DR UCSC; uc008wya.1; mouse. [Q6VH22-2]
DR UCSC; uc008wyb.1; mouse. [Q6VH22-1]
DR CTD; 26160; -.
DR MGI; MGI:2682064; Ift172.
DR VEuPathDB; HostDB:ENSMUSG00000038564; -.
DR eggNOG; KOG3616; Eukaryota.
DR GeneTree; ENSGT00940000153417; -.
DR HOGENOM; CLU_002716_0_0_1; -.
DR InParanoid; Q6VH22; -.
DR OMA; YQQLGMW; -.
DR OrthoDB; 30851at2759; -.
DR PhylomeDB; Q6VH22; -.
DR TreeFam; TF312901; -.
DR Reactome; R-MMU-5610787; Hedgehog 'off' state.
DR Reactome; R-MMU-5620924; Intraflagellar transport.
DR BioGRID-ORCS; 67661; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Ift172; mouse.
DR PRO; PR:Q6VH22; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q6VH22; protein.
DR Bgee; ENSMUSG00000038564; Expressed in seminiferous tubule of testis and 248 other tissues.
DR ExpressionAtlas; Q6VH22; baseline and differential.
DR Genevisible; Q6VH22; MM.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR GO; GO:0005929; C:cilium; IDA:UniProtKB.
DR GO; GO:0030992; C:intraciliary transport particle B; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0097598; C:sperm cytoplasmic droplet; IDA:MGI.
DR GO; GO:0097225; C:sperm midpiece; IDA:MGI.
DR GO; GO:0097228; C:sperm principal piece; IDA:MGI.
DR GO; GO:0060348; P:bone development; IMP:MGI.
DR GO; GO:0007420; P:brain development; IMP:MGI.
DR GO; GO:0060271; P:cilium assembly; IMP:UniProtKB.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IMP:MGI.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:MGI.
DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; IMP:MGI.
DR GO; GO:0008544; P:epidermis development; IMP:MGI.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR GO; GO:0001947; P:heart looping; IMP:MGI.
DR GO; GO:0061525; P:hindgut development; IMP:MGI.
DR GO; GO:0035720; P:intraciliary anterograde transport; IC:ComplexPortal.
DR GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR GO; GO:0043616; P:keratinocyte proliferation; IMP:MGI.
DR GO; GO:0070986; P:left/right axis specification; IMP:MGI.
DR GO; GO:0060173; P:limb development; IMP:MGI.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.
DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IMP:MGI.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0001843; P:neural tube closure; IMP:MGI.
DR GO; GO:0021915; P:neural tube development; IMP:MGI.
DR GO; GO:0001841; P:neural tube formation; IMP:MGI.
DR GO; GO:1905515; P:non-motile cilium assembly; IMP:MGI.
DR GO; GO:0007219; P:Notch signaling pathway; IMP:MGI.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IMP:MGI.
DR GO; GO:0016485; P:protein processing; IMP:MGI.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; IMP:MGI.
DR GO; GO:0060021; P:roof of mouth development; IMP:MGI.
DR GO; GO:0007224; P:smoothened signaling pathway; IMP:UniProtKB.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:MGI.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cell projection; Cilium;
KW Developmental protein; Isopeptide bond; Methylation; Reference proteome;
KW Repeat; TPR repeat; Ubl conjugation; WD repeat.
FT CHAIN 1..1749
FT /note="Intraflagellar transport protein 172 homolog"
FT /id="PRO_0000328942"
FT REPEAT 14..53
FT /note="WD 1"
FT REPEAT 64..103
FT /note="WD 2"
FT REPEAT 110..148
FT /note="WD 3"
FT REPEAT 150..191
FT /note="WD 4"
FT REPEAT 195..233
FT /note="WD 5"
FT REPEAT 238..278
FT /note="WD 6"
FT REPEAT 284..323
FT /note="WD 7"
FT REPEAT 483..520
FT /note="WD 8"
FT REPEAT 521..559
FT /note="WD 9"
FT REPEAT 593..624
FT /note="TPR 1"
FT REPEAT 692..725
FT /note="TPR 2"
FT REPEAT 809..842
FT /note="TPR 3"
FT REPEAT 854..887
FT /note="TPR 4"
FT REPEAT 912..945
FT /note="TPR 5"
FT REPEAT 947..970
FT /note="TPR 6"
FT REPEAT 971..1004
FT /note="TPR 7"
FT REPEAT 1042..1075
FT /note="TPR 8"
FT REPEAT 1142..1175
FT /note="TPR 9"
FT REPEAT 1276..1309
FT /note="TPR 10"
FT REPEAT 1345..1378
FT /note="TPR 11"
FT REPEAT 1411..1445
FT /note="TPR 12"
FT REPEAT 1447..1477
FT /note="TPR 13"
FT REPEAT 1574..1607
FT /note="TPR 14"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9UG01"
FT MOD_RES 672
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CROSSLNK 4
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:Q9UG01"
FT VAR_SEQ 1..1591
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_032850"
FT MUTAGEN 1564
FT /note="L->P: In wim; embryos arrest at 10.5-11.5 dpc and
FT display an open neural tube in the head that lack the
FT normal groove on the ventral midline. They lack ventral
FT neural cell types and display other phenotypes
FT characteristic of defects in Sonic hedgehog signaling."
FT /evidence="ECO:0000269|PubMed:14603322"
FT CONFLICT 949
FT /note="T -> I (in Ref. 3; AAH66096)"
FT /evidence="ECO:0000305"
FT CONFLICT 1506
FT /note="L -> F (in Ref. 3; AAH51928)"
FT /evidence="ECO:0000305"
FT CONFLICT 1511
FT /note="F -> S (in Ref. 3; AAH66096)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1749 AA; 197548 MW; 59277DEBE5B1C1B2 CRC64;
MQLKHLRTLL SPQDGAAKVT CMAWSQNNAK FAVCTVDRVV LLYDEHGERR DKFSTKPADM
KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG DKKVICNKFI QTSAVTCLQW
PAEYVIVFGL AEGKVRLANT KTNKSSTIYG TESYVVALTT NCSGKGILSG HADGTIVRYF
FDDEGSGESQ GKLVNHPCPP YALAWATNSI VAAGCDRRIV AYGKEGHVLQ TFDYSRDPQE
REFTTAAASP GGQSVVLGSY DRLRVFNWSP RRSIWEEAKP KEIANLYTVT ALAWKRDGSR
LCAGTLCGGV EQFDCCLRRS IYKNKFELTY VGPSQVIVKN LSSGTRVVLK SHYGYEVEEV
KILGKERYLV AHTSDTLLLG DLNTNRLSEI AWQGSGGNEK YFFENENVCM IFNAGELTLV
EYGSNDSLGS VRTEFMNPHL ISVRINERCQ RGMEDNKKLA YLVDIKTIAI VDLIGGYNIG
TISHESRVDW LELNETGHKL LFRDRKLRLH LYDIESCSKT MILNFCSYVQ WVPGSDVLVA
QNRNSLCVWY NIEAPERVTM SSIRGDVVGL ERGGGKTEVM VTEGVTTVAY TLDEGLIEFG
TAIDDGNYTR ATAFLETLEM TPETEAMWKT LSKLALEARQ LHTAERCFSA LGHVAKARFL
HETNEIADQV SREYGGEGTD FYQVRARLAM LEKNYKLAEM IFLEQNAVEE AMDMYQELHR
WEECIAVAEA KGHPALEKLR RDYYQWLMDT QQEERAGELQ ESQGDGLAAI SLYLKAGLPA
KAARLVLTRE ELLANTELVE HITTALIKGE LYERAGDLFE KIRNPQRALE CYCKGNAFMK
AVELARLAFP VEVVRLEEAW GDHLVQQKQL DAAINHYIEA RCSIKAIEAA LGARQWKKAI
YILDLQDRNT ASKYYPRVAQ HYASLQEYEI AEELYTKGDR TKDAIDMYTQ AGRWEQAHKL
AMKCMRPEDV SVLYITQAQE MEKQGKYREA ERLYVTVEEP DLAITMFKKH KLYDDMIRLV
GKHHPDLLSD THLHLGKELE AEGRLQEAEY HYLEAQEWKA TVNMYRSSGL WEEAYRVAKA
HGGANAHKHV AYLWAKSLGG EAAVRLLNKL GLLEATIDHA ADNCSFEFAF ELSRLAFKHK
APEIHLKYAM YLEDEGKFEE AEAEFIRAGK PKEAVLMFVH NQDWEAAQRV AEAHDPDSVA
EVLVGQARGA LEEKDFQKAE GLLLRAQRPG LALNYYKEAG LWSDALRICK DYVPGQLEAL
QEEYEREATK KGGRGVEGLV EQARQWEQAG EYSRAVDCYL KVRDSGSSGL MEKCWMKAAE
LSIKFLPPQR SLEVVRVVGP QLIGIGKHSA AAELYLNLDL VKEAIDAFIE GEEWNKAKRV
AKELDPRYED YVDQHYKEFL KNQGKVDSLV GVDVVAALDL YVEQGQWDKC IETATKQNYK
ILHKYVALYA THLIREGGYA QALALYVQHG APANPQNFNI YKRIFTDMVS SPGTNNAEAY
HSWADLRDVL FNLCENLVKS SEANSAAHEE FEMMLLISHY YATRSAAQSI KQLETVAARL
SVSLLRHTQL LPADKAFYEA GTAAKEVGWE NMAFIFLNRF LDLTDAIEEG TLDALDHSDF
QDTDIPFEVP LPAKQHVPEA QREEVRDWVL TVSMDQRLEQ VLPRDERGVY EASLVAASTG
VRALPCLITG YPILRNKIEF KRPGKAANKD NWNKFLMAIK TSHSPVCQDV LKFISQWCGG
LPSTSFSFQ
