IF172_RAT
ID IF172_RAT Reviewed; 1749 AA.
AC Q9JKU3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Intraflagellar transport protein 172 homolog;
DE AltName: Full=Selective LIM-binding factor;
GN Name=Ift172; Synonyms=Slb;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, POSSIBLE INTERACTION WITH
RP LHX3 AND LHX4, AND TISSUE SPECIFICITY.
RX PubMed=10788441; DOI=10.1074/jbc.275.18.13336;
RA Howard P.W., Maurer R.A.;
RT "Identification of a conserved protein that interacts with specific LIM
RT homeodomain transcription factors.";
RL J. Biol. Chem. 275:13336-13342(2000).
CC -!- FUNCTION: Required for the maintenance and formation of cilia. Plays an
CC indirect role in hedgehog (Hh) signaling, cilia being required for all
CC activity of the hedgehog pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IFT88 (By similarity). Interacts with IFT57 (By
CC similarity). Interacts with RABL2/RABL2A; binds preferentially to GDP-
CC bound RABL2 (By similarity). May interact with LHX3 and LHX4; the
CC relevance of such interaction is however unclear in vivo. {ECO:0000250,
CC ECO:0000250|UniProtKB:Q6VH22}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. Nucleus
CC {ECO:0000269|PubMed:10788441}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the testis and pituitary cells.
CC {ECO:0000269|PubMed:10788441}.
CC -!- SIMILARITY: Belongs to the IFT172 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF226993; AAF68274.1; -; mRNA.
DR RefSeq; NP_446244.1; NM_053792.1.
DR AlphaFoldDB; Q9JKU3; -.
DR STRING; 10116.ENSRNOP00000066409; -.
DR iPTMnet; Q9JKU3; -.
DR PhosphoSitePlus; Q9JKU3; -.
DR PRIDE; Q9JKU3; -.
DR GeneID; 116475; -.
DR KEGG; rno:116475; -.
DR CTD; 26160; -.
DR RGD; 620744; Ift172.
DR eggNOG; KOG3616; Eukaryota.
DR InParanoid; Q9JKU3; -.
DR OrthoDB; 30851at2759; -.
DR PhylomeDB; Q9JKU3; -.
DR Reactome; R-RNO-5610787; Hedgehog 'off' state.
DR Reactome; R-RNO-5620924; Intraflagellar transport.
DR PRO; PR:Q9JKU3; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0030992; C:intraciliary transport particle B; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0097598; C:sperm cytoplasmic droplet; ISO:RGD.
DR GO; GO:0097225; C:sperm midpiece; ISO:RGD.
DR GO; GO:0097228; C:sperm principal piece; ISO:RGD.
DR GO; GO:0060348; P:bone development; ISO:RGD.
DR GO; GO:0007420; P:brain development; ISO:RGD.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; ISO:RGD.
DR GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; ISO:RGD.
DR GO; GO:0048596; P:embryonic camera-type eye morphogenesis; ISO:RGD.
DR GO; GO:0008544; P:epidermis development; ISO:RGD.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0001947; P:heart looping; ISO:RGD.
DR GO; GO:0061525; P:hindgut development; ISO:RGD.
DR GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR GO; GO:0070986; P:left/right axis specification; ISO:RGD.
DR GO; GO:0060173; P:limb development; ISO:RGD.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:RGD.
DR GO; GO:0001843; P:neural tube closure; ISO:RGD.
DR GO; GO:0021915; P:neural tube development; ISO:RGD.
DR GO; GO:0001841; P:neural tube formation; ISO:RGD.
DR GO; GO:1905515; P:non-motile cilium assembly; ISO:RGD.
DR GO; GO:0007219; P:Notch signaling pathway; ISO:RGD.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISO:RGD.
DR GO; GO:0016485; P:protein processing; ISO:RGD.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; ISO:RGD.
DR GO; GO:0060021; P:roof of mouth development; ISO:RGD.
DR GO; GO:0007224; P:smoothened signaling pathway; ISO:RGD.
DR GO; GO:0021522; P:spinal cord motor neuron differentiation; ISO:RGD.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell projection; Cilium; Developmental protein;
KW Isopeptide bond; Methylation; Nucleus; Reference proteome; Repeat;
KW TPR repeat; Ubl conjugation; WD repeat.
FT CHAIN 1..1749
FT /note="Intraflagellar transport protein 172 homolog"
FT /id="PRO_0000328943"
FT REPEAT 14..53
FT /note="WD 1"
FT REPEAT 64..103
FT /note="WD 2"
FT REPEAT 110..148
FT /note="WD 3"
FT REPEAT 150..191
FT /note="WD 4"
FT REPEAT 195..233
FT /note="WD 5"
FT REPEAT 238..278
FT /note="WD 6"
FT REPEAT 284..323
FT /note="WD 7"
FT REPEAT 483..520
FT /note="WD 8"
FT REPEAT 521..559
FT /note="WD 9"
FT REPEAT 593..624
FT /note="TPR 1"
FT REPEAT 692..725
FT /note="TPR 2"
FT REPEAT 809..842
FT /note="TPR 3"
FT REPEAT 854..887
FT /note="TPR 4"
FT REPEAT 912..945
FT /note="TPR 5"
FT REPEAT 947..970
FT /note="TPR 6"
FT REPEAT 971..1004
FT /note="TPR 7"
FT REPEAT 1042..1075
FT /note="TPR 8"
FT REPEAT 1142..1175
FT /note="TPR 9"
FT REPEAT 1276..1309
FT /note="TPR 10"
FT REPEAT 1345..1378
FT /note="TPR 11"
FT REPEAT 1411..1445
FT /note="TPR 12"
FT REPEAT 1447..1477
FT /note="TPR 13"
FT REPEAT 1574..1607
FT /note="TPR 14"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9UG01"
FT MOD_RES 672
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6VH22"
FT CROSSLNK 4
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:Q9UG01"
SQ SEQUENCE 1749 AA; 197603 MW; B72C79207F5C0AA5 CRC64;
MQLKHLRTLL SPQDGAAKVT CMAWSQNNAK FAVCTVDRVV LLYDEHGERR DKFSTKPADM
KYGRKSYMVK GMAFSPDSTK IAIGQTDNII YVYKIGEDWG DKKVICNKFI QTSAVTCLQW
PAEYIIVFGL AEGKVRLANT KTNKSSTIYG TDSYVVALTT NCSGKGILSG HADGTIVRYF
FDDEGSGESQ GKLVNHPCPP YALAWATNSI VAAGCDRRIV AYGKEGHVLQ TFDYSRDPQE
REFTTAAASP GGQSVVLGSY DRLRVFNWSP RRSIWEEAKP KEIANLYTVT ALAWKRDGSR
LCAGTLCGGV EQFDCCLRRS IYKNKFELTY VGPSQLIVKN LSSGTRVVLK SHYGYEVEEV
KILGKERYLV AHTSDTLLLG DLNTNRLSEI PWQGSGGNEK YFFENENVCM IFNAGELTLV
EYGSNDSLGS VRTEFMNPHL ISVRINERCQ RGMEDNKKLA YLVDIKTIAI VDLIGGYNIG
TISHESRVDW LELNETGHKL LFRDRKLRLH LYDIESCSKT MILNFCSYVQ WVPGSDVLVA
QNRNSLCVWY NIEAPERVTM SSIRGDVVGL ERGGGKTEVM VTEGVTTVAY TLDEGLIEFG
TAIDDGNYTR ATAFLETLEM TPETEAMWKT LSKLALEARQ LHTAERCFSA LGHVAKARFL
HETNEIADQV SREYGGEGTD FYQVRARLAM LEKNYKLAEM IFLEQNAVEE AMDMYQELHR
WDECIAVAEA KGHPALEKLR RDYYQRLMDT QQEERAGELQ ESQGDGLAAI SLYLKAGLPA
KAARLVLTRE ELLANTELVE HITTALIKGE LYERAGDLFE KIRNPQRALE CYCKGNAFMK
AVELARLAFP VEVVRLEEAW GDHLVQQKQL DAAINHYIEA RCSIKAIEAA LGARQWKKAI
YILDLQDRNT ASKYYPRVAQ HYASLQEYEI AEELYTKGDR TKDAIDMYTQ AGRWEQAHKL
AMKCMRPEDV SVLYITQAQE MEKQGKYREA ERLYVTVEEP DLAITMFKKH KLYDDMIRLV
GKHHPDLLSD THLHLGKELE TEGRLQEAEY HYLEAQEWKA TVNMYRSSGL WEEAYRVAKA
HGGANAHKHV AYLWAKSLGG EAAVRLLNKL GLLEAAIDHA ADNCSFEFAF ELSRLALKHK
TPEIHLRYAM YLEDEGKFEE AEAEFIRAGK PKEAVLMFVH NQDWEAAQRV AEAHDPDSVA
EVLVGQARGA LEEKDFQKAE GLLLRAQRPG LALNYYKEAG LWSDALRICK DYVPGQLEAL
QEEYEREATK KGGRGVEGLV EQARQWEQAG EYSRAVDCYL KVRDSGSSGL MEKCWMKAAE
LSIKFLPPQR SLEVVRVVGP QLIGIGKHSA SAELYLNLDL VKEAIDAFIE GEEWNKAKRV
AKELDPRYED YVDQHYKEFL KNQGKVDSLV GVDVVAALDL YVEQGQWDKC IETATKQNYK
ILHKYVALYA THLIREGGYA QALALYVQHG APANPQNFNI YKRIFTDMVS SPGTNNAEAY
HSWADLRDVL FNLCENLVKS SEANSAAHEE FEMMLLIAHY YATRSAAQSI KQLETVAARL
SVSLLRHTQL LPADKAFYEA GTAAKEVGWE NMAFIFFNRF LDLTDAIEEG TLDALDHSDF
QDTDIPFEVP LPAKQHVPEA QREEVRDWVL TVSMDQRLEQ VLPRDERGVY EASLVAASTG
VRALPCLITG YPILRNKIEF KRPGKAANKD NWNKFLMAIK TSHSPVCQDV LKFISQWCGG
LPSTSFSFQ
