ID   IF1AX_PONAB             Reviewed;         144 AA.
AC   Q5RA42;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Eukaryotic translation initiation factor 1A, X-chromosomal;
DE            Short=eIF-1A X isoform;
DE   AltName: Full=Eukaryotic translation initiation factor 4C;
DE            Short=eIF-4C;
GN   Name=EIF1AX;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to be required for maximal rate of protein
CC       biosynthesis. Enhances ribosome dissociation into subunits and
CC       stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000305}.
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DR   EMBL; CR859179; CAH91368.1; -; mRNA.
DR   RefSeq; NP_001125807.1; NM_001132335.1.
DR   AlphaFoldDB; Q5RA42; -.
DR   BMRB; Q5RA42; -.
DR   SMR; Q5RA42; -.
DR   STRING; 9601.ENSPPYP00000022574; -.
DR   Ensembl; ENSPPYT00000042325; ENSPPYP00000029438; ENSPPYG00000038921.
DR   GeneID; 100172735; -.
DR   KEGG; pon:100172735; -.
DR   CTD; 1964; -.
DR   eggNOG; KOG3403; Eukaryota.
DR   GeneTree; ENSGT00390000008256; -.
DR   HOGENOM; CLU_109098_0_1_1; -.
DR   InParanoid; Q5RA42; -.
DR   OMA; KMEDQEY; -.
DR   OrthoDB; 1426335at2759; -.
DR   TreeFam; TF350394; -.
DR   Proteomes; UP000001595; Chromosome X.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd05793; S1_IF1A; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_00216; aIF_1A; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR   InterPro; IPR001253; TIF_eIF-1A.
DR   InterPro; IPR018104; TIF_eIF-1A_CS.
DR   PANTHER; PTHR21668; PTHR21668; 1.
DR   Pfam; PF01176; eIF-1a; 1.
DR   SMART; SM00652; eIF1a; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00523; eIF-1A; 1.
DR   PROSITE; PS01262; IF1A; 1.
DR   PROSITE; PS50832; S1_IF1_TYPE; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..144
FT                   /note="Eukaryotic translation initiation factor 1A, X-
FT                   chromosomal"
FT                   /id="PRO_0000145104"
FT   DOMAIN          22..96
FT                   /note="S1-like"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..144
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   144 AA;  16460 MW;  1C4209855B21BFD4 CRC64;
     MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVKRLCH
     IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
     FGPGDDDEIQ FDDIGDDDED IDDI