IF1AY_HUMAN
ID IF1AY_HUMAN Reviewed; 144 AA.
AC O14602; Q9BS77;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Eukaryotic translation initiation factor 1A, Y-chromosomal;
DE Short=eIF-1A Y isoform;
DE AltName: Full=Eukaryotic translation initiation factor 4C;
DE Short=eIF-4C;
GN Name=EIF1AY;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9381176; DOI=10.1126/science.278.5338.675;
RA Lahn B.T., Page D.C.;
RT "Functional coherence of the human Y chromosome.";
RL Science 278:675-680(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Seems to be required for maximal rate of protein
CC biosynthesis. Enhances ribosome dissociation into subunits and
CC stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC subunits (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC O14602; P54253: ATXN1; NbExp=7; IntAct=EBI-286439, EBI-930964;
CC O14602; O60841: EIF5B; NbExp=2; IntAct=EBI-286439, EBI-928530;
CC O14602; P41235-3: HNF4A; NbExp=3; IntAct=EBI-286439, EBI-12690684;
CC O14602; P42858: HTT; NbExp=6; IntAct=EBI-286439, EBI-466029;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000305}.
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DR EMBL; AF000987; AAC51834.1; -; mRNA.
DR EMBL; BT007201; AAP35865.1; -; mRNA.
DR EMBL; BC005248; AAH05248.1; -; mRNA.
DR CCDS; CCDS14795.1; -.
DR PIR; C53045; C53045.
DR RefSeq; NP_001265541.1; NM_001278612.1.
DR RefSeq; NP_004672.2; NM_004681.3.
DR AlphaFoldDB; O14602; -.
DR BMRB; O14602; -.
DR SMR; O14602; -.
DR BioGRID; 114542; 20.
DR IntAct; O14602; 17.
DR MINT; O14602; -.
DR iPTMnet; O14602; -.
DR PhosphoSitePlus; O14602; -.
DR SwissPalm; O14602; -.
DR BioMuta; EIF1AY; -.
DR EPD; O14602; -.
DR jPOST; O14602; -.
DR MassIVE; O14602; -.
DR MaxQB; O14602; -.
DR PaxDb; O14602; -.
DR PeptideAtlas; O14602; -.
DR PRIDE; O14602; -.
DR ProteomicsDB; 48107; -.
DR TopDownProteomics; O14602; -.
DR Antibodypedia; 21880; 228 antibodies from 24 providers.
DR DNASU; 9086; -.
DR Ensembl; ENST00000361365.7; ENSP00000354722.2; ENSG00000198692.10.
DR GeneID; 9086; -.
DR KEGG; hsa:9086; -.
DR MANE-Select; ENST00000361365.7; ENSP00000354722.2; NM_004681.4; NP_004672.2.
DR UCSC; uc004fuk.5; human.
DR CTD; 9086; -.
DR DisGeNET; 9086; -.
DR GeneCards; EIF1AY; -.
DR HGNC; HGNC:3252; EIF1AY.
DR HPA; ENSG00000198692; Tissue enhanced (heart muscle, tongue).
DR MIM; 400014; gene.
DR neXtProt; NX_O14602; -.
DR OpenTargets; ENSG00000198692; -.
DR PharmGKB; PA27686; -.
DR VEuPathDB; HostDB:ENSG00000198692; -.
DR GeneTree; ENSGT00390000008256; -.
DR HOGENOM; CLU_109098_0_1_1; -.
DR InParanoid; O14602; -.
DR OMA; IWINNGD; -.
DR OrthoDB; 1426335at2759; -.
DR PhylomeDB; O14602; -.
DR TreeFam; TF350394; -.
DR PathwayCommons; O14602; -.
DR SignaLink; O14602; -.
DR BioGRID-ORCS; 9086; 116 hits in 664 CRISPR screens.
DR ChiTaRS; EIF1AY; human.
DR GeneWiki; EIF1AY; -.
DR GenomeRNAi; 9086; -.
DR Pharos; O14602; Tdark.
DR PRO; PR:O14602; -.
DR Proteomes; UP000005640; Chromosome Y.
DR RNAct; O14602; protein.
DR Bgee; ENSG00000198692; Expressed in trabecular bone tissue and 179 other tissues.
DR ExpressionAtlas; O14602; baseline and differential.
DR Genevisible; O14602; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd05793; S1_IF1A; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00216; aIF_1A; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR InterPro; IPR018104; TIF_eIF-1A_CS.
DR PANTHER; PTHR21668; PTHR21668; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00523; eIF-1A; 1.
DR PROSITE; PS01262; IF1A; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 1: Evidence at protein level;
KW Initiation factor; Isopeptide bond; Protein biosynthesis;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..144
FT /note="Eukaryotic translation initiation factor 1A, Y-
FT chromosomal"
FT /id="PRO_0000145102"
FT DOMAIN 22..96
FT /note="S1-like"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..144
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 88
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT CONFLICT 108
FT /note="E -> G (in Ref. 1; AAC51834)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 144 AA; 16442 MW; 1DE91334F191BEC5 CRC64;
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
FGPGDDDEIQ FDDIGDDDED IDDI
