IF1AY_PANTR
ID IF1AY_PANTR Reviewed; 144 AA.
AC Q6GVM3;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Eukaryotic translation initiation factor 1A, Y-chromosomal;
DE Short=eIF-1A Y isoform;
DE AltName: Full=Eukaryotic translation initiation factor 4C;
DE Short=eIF-4C;
GN Name=EIF1AY;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hughes J.F., Pyntikova T., Skaletsky H., Minx P.J., Rozen S., Wilson R.K.,
RA Page D.C.;
RT "The DNA sequence of the chimpanzee Y chromosome.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Seems to be required for maximal rate of protein
CC biosynthesis. Enhances ribosome dissociation into subunits and
CC stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC subunits (By similarity). {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000305}.
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DR EMBL; AY633115; AAT46352.1; -; mRNA.
DR RefSeq; NP_001008977.1; NM_001008977.1.
DR AlphaFoldDB; Q6GVM3; -.
DR SMR; Q6GVM3; -.
DR STRING; 9598.ENSPTRP00000038797; -.
DR PaxDb; Q6GVM3; -.
DR Ensembl; ENSPTRT00000042030; ENSPTRP00000038797; ENSPTRG00000022504.
DR GeneID; 449499; -.
DR KEGG; ptr:449499; -.
DR CTD; 9086; -.
DR eggNOG; KOG3403; Eukaryota.
DR GeneTree; ENSGT00390000008256; -.
DR HOGENOM; CLU_109098_0_1_1; -.
DR InParanoid; Q6GVM3; -.
DR OMA; KMEDQEY; -.
DR OrthoDB; 1426335at2759; -.
DR TreeFam; TF350394; -.
DR Proteomes; UP000002277; Chromosome Y.
DR Bgee; ENSPTRG00000022504; Expressed in testis and 20 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd05793; S1_IF1A; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00216; aIF_1A; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR InterPro; IPR018104; TIF_eIF-1A_CS.
DR PANTHER; PTHR21668; PTHR21668; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00523; eIF-1A; 1.
DR PROSITE; PS01262; IF1A; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 2: Evidence at transcript level;
KW Initiation factor; Isopeptide bond; Protein biosynthesis;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..144
FT /note="Eukaryotic translation initiation factor 1A, Y-
FT chromosomal"
FT /id="PRO_0000145103"
FT DOMAIN 22..96
FT /note="S1-like"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..144
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 88
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250|UniProtKB:O14602"
SQ SEQUENCE 144 AA; 16428 MW; F1391334F191BEDD CRC64;
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAL CFDGVKRLCH
IRGKLRKKVW INTSDIILVG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
FGPGDDDEVQ FDDIGDDDED IDDI
