IF1A_DESA1
ID IF1A_DESA1 Reviewed; 116 AA.
AC B8D5N1;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Translation initiation factor 1A {ECO:0000255|HAMAP-Rule:MF_00216};
DE Short=aIF-1A {ECO:0000255|HAMAP-Rule:MF_00216};
GN Name=eIF1A; OrderedLocusNames=DKAM_1086;
OS Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 /
OS 1221n) (Desulfurococcus kamchatkensis).
OC Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC Desulfurococcaceae; Desulfurococcus.
OX NCBI_TaxID=490899;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 18924 / JCM 16383 / VKM B-2413 / 1221n;
RX PubMed=19114480; DOI=10.1128/jb.01525-08;
RA Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V.,
RA Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G.;
RT "Complete genome sequence of the anaerobic, protein-degrading
RT hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis.";
RL J. Bacteriol. 191:2371-2379(2009).
CC -!- FUNCTION: Seems to be required for maximal rate of protein
CC biosynthesis. Enhances ribosome dissociation into subunits and
CC stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC subunits. {ECO:0000255|HAMAP-Rule:MF_00216}.
CC -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000255|HAMAP-
CC Rule:MF_00216}.
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DR EMBL; CP001140; ACL11412.1; -; Genomic_DNA.
DR RefSeq; WP_012608753.1; NC_011766.1.
DR AlphaFoldDB; B8D5N1; -.
DR SMR; B8D5N1; -.
DR STRING; 490899.DKAM_1086; -.
DR EnsemblBacteria; ACL11412; ACL11412; DKAM_1086.
DR GeneID; 7171187; -.
DR KEGG; dka:DKAM_1086; -.
DR eggNOG; arCOG01179; Archaea.
DR HOGENOM; CLU_109098_1_2_2; -.
DR OMA; TVIVVPW; -.
DR Proteomes; UP000006903; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd05793; S1_IF1A; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00216; aIF_1A; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR PANTHER; PTHR21668; PTHR21668; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..116
FT /note="Translation initiation factor 1A"
FT /id="PRO_1000124814"
FT DOMAIN 17..91
FT /note="S1-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00216"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 116 AA; 12997 MW; A89EC87A597CDF22 CRC64;
MRCLSKKHQK QGDEHGGEIP LPNPDEGTII CGVVRHLGGD YLIAKCLDGV DRKIRIPGKL
RRKVWITEGD IILVGLWDFS SEKGEVVYKY GKNEVNKLVE KGVVPKEFID ALSELI