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IF1A_METJA
ID   IF1A_METJA              Reviewed;         102 AA.
AC   Q57887;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Translation initiation factor 1A;
DE            Short=aIF-1A;
GN   Name=eIF1A; OrderedLocusNames=MJ0445;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   STRUCTURE BY NMR.
RX   PubMed=11714910; DOI=10.1110/ps.18201;
RA   Li W., Hoffman D.W.;
RT   "Structure and dynamics of translation initiation factor aIF-1A from the
RT   archaeon Methanococcus jannaschii determined by NMR spectroscopy.";
RL   Protein Sci. 10:2426-2438(2001).
CC   -!- FUNCTION: Seems to be required for maximal rate of protein
CC       biosynthesis. Enhances ribosome dissociation into subunits and
CC       stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98435.1; -; Genomic_DNA.
DR   PIR; E64355; E64355.
DR   RefSeq; WP_010869944.1; NC_000909.1.
DR   PDB; 1JT8; NMR; -; A=1-102.
DR   PDBsum; 1JT8; -.
DR   AlphaFoldDB; Q57887; -.
DR   SMR; Q57887; -.
DR   STRING; 243232.MJ_0445; -.
DR   EnsemblBacteria; AAB98435; AAB98435; MJ_0445.
DR   GeneID; 1451305; -.
DR   KEGG; mja:MJ_0445; -.
DR   eggNOG; arCOG01179; Archaea.
DR   HOGENOM; CLU_109098_1_2_2; -.
DR   InParanoid; Q57887; -.
DR   OMA; ADITWRY; -.
DR   OrthoDB; 102432at2157; -.
DR   PhylomeDB; Q57887; -.
DR   EvolutionaryTrace; Q57887; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_00216; aIF_1A; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR   InterPro; IPR001253; TIF_eIF-1A.
DR   InterPro; IPR018104; TIF_eIF-1A_CS.
DR   PANTHER; PTHR21668; PTHR21668; 1.
DR   Pfam; PF01176; eIF-1a; 1.
DR   SMART; SM00652; eIF1a; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00523; eIF-1A; 1.
DR   PROSITE; PS01262; IF1A; 1.
DR   PROSITE; PS50832; S1_IF1_TYPE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..102
FT                   /note="Translation initiation factor 1A"
FT                   /id="PRO_0000145121"
FT   DOMAIN          10..85
FT                   /note="S1-like"
FT   STRAND          22..27
FT                   /evidence="ECO:0007829|PDB:1JT8"
FT   STRAND          32..40
FT                   /evidence="ECO:0007829|PDB:1JT8"
FT   STRAND          43..48
FT                   /evidence="ECO:0007829|PDB:1JT8"
FT   HELIX           51..57
FT                   /evidence="ECO:0007829|PDB:1JT8"
FT   STRAND          63..67
FT                   /evidence="ECO:0007829|PDB:1JT8"
FT   STRAND          75..85
FT                   /evidence="ECO:0007829|PDB:1JT8"
FT   HELIX           88..100
FT                   /evidence="ECO:0007829|PDB:1JT8"
SQ   SEQUENCE   102 AA;  12184 MW;  8082FD686A103FC0 CRC64;
     MAEQQQEQQI RVRIPRKEEN EILGIIEQML GASRVRVRCL DGKTRLGRIP GRLKNRIWVR
     EGDVVIVKPW EVQGDQKCDI IWRYTKTQVE WLKRKGYLDE LL
 
 
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