IF1A_METMP
ID IF1A_METMP Reviewed; 104 AA.
AC Q6LZM1;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Translation initiation factor 1A {ECO:0000255|HAMAP-Rule:MF_00216};
DE Short=aIF-1A {ECO:0000255|HAMAP-Rule:MF_00216};
GN Name=eif1a {ECO:0000255|HAMAP-Rule:MF_00216}; OrderedLocusNames=MMP0603;
OS Methanococcus maripaludis (strain S2 / LL).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=267377;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S2 / LL;
RX PubMed=15466049; DOI=10.1128/jb.186.20.6956-6969.2004;
RA Hendrickson E.L., Kaul R., Zhou Y., Bovee D., Chapman P., Chung J.,
RA Conway de Macario E., Dodsworth J.A., Gillett W., Graham D.E., Hackett M.,
RA Haydock A.K., Kang A., Land M.L., Levy R., Lie T.J., Major T.A.,
RA Moore B.C., Porat I., Palmeiri A., Rouse G., Saenphimmachak C., Soell D.,
RA Van Dien S., Wang T., Whitman W.B., Xia Q., Zhang Y., Larimer F.W.,
RA Olson M.V., Leigh J.A.;
RT "Complete genome sequence of the genetically tractable hydrogenotrophic
RT methanogen Methanococcus maripaludis.";
RL J. Bacteriol. 186:6956-6969(2004).
CC -!- FUNCTION: Seems to be required for maximal rate of protein
CC biosynthesis. Enhances ribosome dissociation into subunits and
CC stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC subunits. {ECO:0000255|HAMAP-Rule:MF_00216}.
CC -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000255|HAMAP-
CC Rule:MF_00216}.
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DR EMBL; BX950229; CAF30159.1; -; Genomic_DNA.
DR RefSeq; WP_011170547.1; NC_005791.1.
DR AlphaFoldDB; Q6LZM1; -.
DR SMR; Q6LZM1; -.
DR STRING; 267377.MMP0603; -.
DR EnsemblBacteria; CAF30159; CAF30159; MMP0603.
DR GeneID; 41279069; -.
DR KEGG; mmp:MMP0603; -.
DR PATRIC; fig|267377.15.peg.617; -.
DR eggNOG; arCOG01179; Archaea.
DR HOGENOM; CLU_109098_1_2_2; -.
DR OMA; ADITWRY; -.
DR OrthoDB; 102432at2157; -.
DR BioCyc; MMAR267377:MMP_RS03175-MON; -.
DR Proteomes; UP000000590; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd05793; S1_IF1A; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00216; aIF_1A; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR InterPro; IPR018104; TIF_eIF-1A_CS.
DR PANTHER; PTHR21668; PTHR21668; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00523; eIF-1A; 1.
DR PROSITE; PS01262; IF1A; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..104
FT /note="Translation initiation factor 1A"
FT /id="PRO_0000145125"
FT DOMAIN 12..87
FT /note="S1-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00216"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 104 AA; 12355 MW; 945AB18B65EBFB74 CRC64;
MRGQQTPPQQ PTRVRTPREN ENEVLGVIEQ MLGASRVRVR CMDGKLRMGR IPGKLKRKIW
VREDDVVIVT PWEVQSDEKC DVIWRYTKGQ VDWLNRKGYL DFMR