IF1A_MOUSE
ID IF1A_MOUSE Reviewed; 144 AA.
AC Q60872; O88847; Q8R2M4; Q9CX76; Q9DB61;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Eukaryotic translation initiation factor 1A;
DE Short=eIF-1A;
DE AltName: Full=Eukaryotic translation initiation factor 4C;
DE Short=eIF-4C;
GN Name=Eif1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CF-1;
RX PubMed=9753744; DOI=10.1093/nar/26.20.4739;
RA Davis W. Jr., Schultz R.M.;
RT "Molecular cloning and expression of the mouse translation initiation
RT factor eIF-1A.";
RL Nucleic Acids Res. 26:4739-4747(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Embryonic head, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 78-144.
RC STRAIN=CF-1 X B6D2F1/J;
RX PubMed=8631492; DOI=10.1006/dbio.1996.0065;
RA Davis W. Jr., de Sousa P.A., Schultz R.M.;
RT "Transient expression of translation initiation factor eIF-4C during the 2-
RT cell stage of the preimplantation mouse embryo: identification by mRNA
RT differential display and the role of DNA replication in zygotic gene
RT activation.";
RL Dev. Biol. 174:190-201(1996).
CC -!- FUNCTION: Seems to be required for maximal rate of protein
CC biosynthesis. Enhances ribosome dissociation into subunits and
CC stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC subunits.
CC -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000305}.
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DR EMBL; AF026481; AAC63934.1; -; mRNA.
DR EMBL; AK009026; BAB26034.1; -; mRNA.
DR EMBL; AK013268; BAB28759.1; -; mRNA.
DR EMBL; AK019451; BAB31727.1; -; mRNA.
DR EMBL; BC027437; AAH27437.1; -; mRNA.
DR EMBL; U28419; AAB05664.1; -; mRNA.
DR CCDS; CCDS29233.1; -.
DR RefSeq; NP_034250.3; NM_010120.5.
DR AlphaFoldDB; Q60872; -.
DR BMRB; Q60872; -.
DR SMR; Q60872; -.
DR BioGRID; 199411; 1.
DR IntAct; Q60872; 1.
DR MINT; Q60872; -.
DR STRING; 10090.ENSMUSP00000077223; -.
DR iPTMnet; Q60872; -.
DR PhosphoSitePlus; Q60872; -.
DR SwissPalm; Q60872; -.
DR EPD; Q60872; -.
DR jPOST; Q60872; -.
DR MaxQB; Q60872; -.
DR PaxDb; Q60872; -.
DR PRIDE; Q60872; -.
DR ProteomicsDB; 273093; -.
DR DNASU; 13664; -.
DR Ensembl; ENSMUST00000078079; ENSMUSP00000077223; ENSMUSG00000057561.
DR Ensembl; ENSMUST00000168382; ENSMUSP00000132018; ENSMUSG00000057561.
DR Ensembl; ENSMUST00000235455; ENSMUSP00000157583; ENSMUSG00000057561.
DR Ensembl; ENSMUST00000235973; ENSMUSP00000158565; ENSMUSG00000057561.
DR Ensembl; ENSMUST00000238168; ENSMUSP00000157513; ENSMUSG00000057561.
DR GeneID; 13664; -.
DR KEGG; mmu:13664; -.
DR UCSC; uc008evs.2; mouse.
DR CTD; 13664; -.
DR MGI; MGI:95298; Eif1a.
DR VEuPathDB; HostDB:ENSMUSG00000057561; -.
DR eggNOG; KOG3403; Eukaryota.
DR GeneTree; ENSGT00390000008256; -.
DR HOGENOM; CLU_109098_0_1_1; -.
DR InParanoid; Q60872; -.
DR OMA; KMEDQEY; -.
DR OrthoDB; 1426335at2759; -.
DR PhylomeDB; Q60872; -.
DR TreeFam; TF350394; -.
DR BioGRID-ORCS; 13664; 9 hits in 72 CRISPR screens.
DR ChiTaRS; Eif1a; mouse.
DR PRO; PR:Q60872; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q60872; protein.
DR Bgee; ENSMUSG00000057561; Expressed in seminal vesicle and 256 other tissues.
DR ExpressionAtlas; Q60872; baseline and differential.
DR Genevisible; Q60872; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043023; F:ribosomal large subunit binding; ISO:MGI.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR CDD; cd05793; S1_IF1A; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00216; aIF_1A; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR InterPro; IPR018104; TIF_eIF-1A_CS.
DR PANTHER; PTHR21668; PTHR21668; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00523; eIF-1A; 1.
DR PROSITE; PS01262; IF1A; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 2: Evidence at transcript level;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..144
FT /note="Eukaryotic translation initiation factor 1A"
FT /id="PRO_0000145106"
FT DOMAIN 22..96
FT /note="S1-like"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..144
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 78
FT /note="L -> W (in Ref. 4; AAB05664)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="A -> P (in Ref. 4; AAB05664)"
FT /evidence="ECO:0000305"
FT CONFLICT 106
FT /note="Y -> C (in Ref. 2; BAB31727)"
FT /evidence="ECO:0000305"
FT CONFLICT 118
FT /note="T -> M (in Ref. 4; AAB05664)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="Q -> V (in Ref. 4; AAB05664)"
FT /evidence="ECO:0000305"
FT CONFLICT 136
FT /note="D -> E (in Ref. 4; AAB05664)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 144 AA; 16502 MW; 04D99384C0BBA6D4 CRC64;
MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVRRLCH
IRGKLRKKVW INTSDIILIG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
FGPGDDDEIQ FDDIGDDDED IDDI
