IF1A_NATPD
ID IF1A_NATPD Reviewed; 97 AA.
AC Q3IT14;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Translation initiation factor 1A {ECO:0000255|HAMAP-Rule:MF_00216};
DE Short=aIF-1A {ECO:0000255|HAMAP-Rule:MF_00216};
GN Name=eif1a {ECO:0000255|HAMAP-Rule:MF_00216}; OrderedLocusNames=NP_1258A;
OS Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM
OS 8858 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Natronomonas.
OX NCBI_TaxID=348780;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB
RC 2260 / Gabara;
RX PubMed=16169924; DOI=10.1101/gr.3952905;
RA Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA Oesterhelt D.;
RT "Living with two extremes: conclusions from the genome sequence of
RT Natronomonas pharaonis.";
RL Genome Res. 15:1336-1343(2005).
CC -!- FUNCTION: Seems to be required for maximal rate of protein
CC biosynthesis. Enhances ribosome dissociation into subunits and
CC stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC subunits. {ECO:0000255|HAMAP-Rule:MF_00216}.
CC -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000255|HAMAP-
CC Rule:MF_00216}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR936257; CAI48720.1; -; Genomic_DNA.
DR RefSeq; WP_011322356.1; NC_007426.1.
DR AlphaFoldDB; Q3IT14; -.
DR SMR; Q3IT14; -.
DR STRING; 348780.NP_1258A; -.
DR EnsemblBacteria; CAI48720; CAI48720; NP_1258A.
DR GeneID; 3703261; -.
DR KEGG; nph:NP_1258A; -.
DR eggNOG; arCOG01179; Archaea.
DR HOGENOM; CLU_109098_1_2_2; -.
DR OMA; ADITWRY; -.
DR OrthoDB; 102432at2157; -.
DR Proteomes; UP000002698; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd05793; S1_IF1A; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00216; aIF_1A; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR InterPro; IPR018104; TIF_eIF-1A_CS.
DR PANTHER; PTHR21668; PTHR21668; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00523; eIF-1A; 1.
DR PROSITE; PS01262; IF1A; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..97
FT /note="Translation initiation factor 1A"
FT /id="PRO_0000259370"
FT DOMAIN 6..80
FT /note="S1-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00216"
SQ SEQUENCE 97 AA; 11432 MW; 18371827C89E25A0 CRC64;
MSDNEGRKNL RMPEGDEVFA VVTNMLGANR VKVRCMDGTE RTARIPGRMQ KRIWIREDDV
VLVEPWDWQD EKADVVWRYE KQEADQLREE GHITDSV