ID   IF1A_RAT                Reviewed;         144 AA.
AC   Q6VV72;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Eukaryotic translation initiation factor 1A;
DE            Short=eIF-1A;
DE   AltName: Full=Eukaryotic translation initiation factor 4C;
DE            Short=eIF-4C;
DE   AltName: Full=Liver regeneration-related protein LRRG048;
GN   Name=Eif1a; ORFNames=Ab1-287;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RA   Xu C.S., Li W.Q., Li Y.C., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M.,
RA   Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to be required for maximal rate of protein
CC       biosynthesis. Enhances ribosome dissociation into subunits and
CC       stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000305}.
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DR   EMBL; AY325156; AAP92557.1; -; mRNA.
DR   RefSeq; NP_001008773.2; NM_001008773.2.
DR   RefSeq; XP_006254751.1; XM_006254689.1.
DR   AlphaFoldDB; Q6VV72; -.
DR   SMR; Q6VV72; -.
DR   STRING; 10116.ENSRNOP00000046345; -.
DR   iPTMnet; Q6VV72; -.
DR   PhosphoSitePlus; Q6VV72; -.
DR   jPOST; Q6VV72; -.
DR   PaxDb; Q6VV72; -.
DR   PRIDE; Q6VV72; -.
DR   Ensembl; ENSRNOT00000041237; ENSRNOP00000046345; ENSRNOG00000031421.
DR   Ensembl; ENSRNOT00000099432; ENSRNOP00000094920; ENSRNOG00000031421.
DR   Ensembl; ENSRNOT00000099676; ENSRNOP00000092892; ENSRNOG00000031421.
DR   GeneID; 317163; -.
DR   KEGG; rno:317163; -.
DR   UCSC; RGD:1306331; rat.
DR   CTD; 13664; -.
DR   RGD; 1306331; Eif1a.
DR   eggNOG; KOG3403; Eukaryota.
DR   GeneTree; ENSGT00390000008256; -.
DR   HOGENOM; CLU_109098_0_1_1; -.
DR   InParanoid; Q6VV72; -.
DR   OMA; IWINNGD; -.
DR   OrthoDB; 1426335at2759; -.
DR   PhylomeDB; Q6VV72; -.
DR   TreeFam; TF350394; -.
DR   PRO; PR:Q6VV72; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Bgee; ENSRNOG00000031421; Expressed in duodenum and 20 other tissues.
DR   ExpressionAtlas; Q6VV72; baseline and differential.
DR   Genevisible; Q6VV72; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IDA:RGD.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   CDD; cd05793; S1_IF1A; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_00216; aIF_1A; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR   InterPro; IPR001253; TIF_eIF-1A.
DR   InterPro; IPR018104; TIF_eIF-1A_CS.
DR   PANTHER; PTHR21668; PTHR21668; 1.
DR   Pfam; PF01176; eIF-1a; 1.
DR   SMART; SM00652; eIF1a; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00523; eIF-1A; 1.
DR   PROSITE; PS01262; IF1A; 1.
DR   PROSITE; PS50832; S1_IF1_TYPE; 1.
PE   2: Evidence at transcript level;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..144
FT                   /note="Eukaryotic translation initiation factor 1A"
FT                   /id="PRO_0000145109"
FT   DOMAIN          22..96
FT                   /note="S1-like"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..144
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   144 AA;  16502 MW;  04D99384C0BBA6D4 CRC64;
     MPKNKGKGGK NRRRGKNENE SEKRELVFKE DGQEYAQVIK MLGNGRLEAM CFDGVRRLCH
     IRGKLRKKVW INTSDIILIG LRDYQDNKAD VILKYNADEA RSLKAYGELP EHAKINETDT
     FGPGDDDEIQ FDDIGDDDED IDDI