ID   IF1A_THEAC              Reviewed;         119 AA.
AC   Q03590;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Translation initiation factor 1A;
DE            Short=aIF-1A;
GN   Name=eIF1A; OrderedLocusNames=Ta0393.1;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=1408839; DOI=10.1093/nar/20.19.5226;
RA   Klenk H.-P., Renner O., Schwass V., Zillig W.;
RT   "Nucleotide sequence of the genes encoding the subunits H, B, A' and A'' of
RT   the DNA-dependent RNA polymerase and the initiator tRNA from Thermoplasma
RT   acidophilum.";
RL   Nucleic Acids Res. 20:5226-5226(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
CC   -!- FUNCTION: Seems to be required for maximal rate of protein
CC       biosynthesis. Enhances ribosome dissociation into subunits and
CC       stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC       subunits (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-1A family. {ECO:0000305}.
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DR   EMBL; X68198; CAA48284.1; -; Genomic_DNA.
DR   EMBL; AL445064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; S26726; S26726.
DR   RefSeq; WP_010900823.1; NC_002578.1.
DR   AlphaFoldDB; Q03590; -.
DR   SMR; Q03590; -.
DR   STRING; 273075.Ta0394a; -.
DR   GeneID; 1457131; -.
DR   eggNOG; arCOG01179; Archaea.
DR   OMA; VPWDFQD; -.
DR   OrthoDB; 102432at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd05793; S1_IF1A; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_00216; aIF_1A; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR   InterPro; IPR001253; TIF_eIF-1A.
DR   InterPro; IPR018104; TIF_eIF-1A_CS.
DR   PANTHER; PTHR21668; PTHR21668; 1.
DR   Pfam; PF01176; eIF-1a; 1.
DR   SMART; SM00652; eIF1a; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00523; eIF-1A; 1.
DR   PROSITE; PS01262; IF1A; 1.
DR   PROSITE; PS50832; S1_IF1_TYPE; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..119
FT                   /note="Translation initiation factor 1A"
FT                   /id="PRO_0000145136"
FT   DOMAIN          24..98
FT                   /note="S1-like"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        97
FT                   /note="Y -> N (in Ref. 1; CAA48284)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        118..119
FT                   /note="FK -> SNEVMKDR (in Ref. 1; CAA48284)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   119 AA;  13949 MW;  DB7712FF00E105A8 CRC64;
     MSEDDVDNSV KDFESGEENE ESIGRVILPN KKKGEMFGIV EKMEGASRLS VMCEDGYTRN
     ARIPGRMRKR MWIREKDLVI VKPWEFQPEK ADVVYRYTKT QASYLSRNHM LPEVIDIFK