IF1C_BOROF
ID IF1C_BOROF Reviewed; 77 AA.
AC Q95GM3;
DT 28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2003, sequence version 2.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Translation initiation factor IF-1, chloroplastic {ECO:0000255|HAMAP-Rule:MF_00075};
GN Name=infA {ECO:0000255|HAMAP-Rule:MF_00075};
OS Borago officinalis (Bourrache) (Borage).
OG Plastid; Chloroplast.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Boraginales; Boraginaceae; Boraginoideae; Boragineae;
OC Boragininae; Borago.
OX NCBI_TaxID=13363;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11251102; DOI=10.2307/3871412;
RA Millen R.S., Olmstead R.G., Adams K.L., Palmer J.D., Lao N.T., Heggie L.,
RA Kavanagh T.A., Hibberd J.M., Gray J.C., Morden C.W., Calie P.J.,
RA Jermiin L.S., Wolfe K.H.;
RT "Many parallel losses of infA from chloroplast DNA during angiosperm
RT evolution with multiple independent transfers to the nucleus.";
RL Plant Cell 13:645-658(2001).
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit
CC to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps
CC modulate mRNA selection, yielding the 30S pre-initiation complex (PIC).
CC Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are
CC released leaving the mature 70S translation initiation complex.
CC {ECO:0000255|HAMAP-Rule:MF_00075}.
CC -!- SUBUNIT: Component of the 30S ribosomal translation pre-initiation
CC complex which assembles on the 30S ribosome in the order IF-2 and IF-3,
CC IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at
CC any time during PIC assembly. {ECO:0000255|HAMAP-Rule:MF_00075}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast {ECO:0000255|HAMAP-
CC Rule:MF_00075}.
CC -!- SIMILARITY: Belongs to the IF-1 family. {ECO:0000255|HAMAP-
CC Rule:MF_00075}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK38863.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF347640; AAK38863.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q95GM3; -.
DR SMR; Q95GM3; -.
DR GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR GO; GO:0043022; F:ribosome binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd04451; S1_IF1; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00075; IF_1; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR004368; TIF_IF1.
DR PANTHER; PTHR33370; PTHR33370; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR TIGRFAMs; TIGR00008; infA; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 3: Inferred from homology;
KW Chloroplast; Initiation factor; Plastid; Protein biosynthesis; RNA-binding;
KW rRNA-binding.
FT CHAIN 1..77
FT /note="Translation initiation factor IF-1, chloroplastic"
FT /id="PRO_0000095920"
FT DOMAIN 1..71
FT /note="S1-like"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00075"
SQ SEQUENCE 77 AA; 9137 MW; A4518AC0933D1F21 CRC64;
MKEEKWIHEG LITESLPNGM FRVRLDNEDL VLGYVSGKIR RSFIRILPGD RVKIEVSRYD
STRGRIIYRL RNKDSKD