ID   APCD1_PELSI             Reviewed;         515 AA.
AC   Q5R2J4;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Protein APCDD1;
DE   AltName: Full=Adenomatosis polyposis coli down-regulated 1 protein homolog;
DE            Short=PsAPCDD1;
DE   Flags: Precursor;
GN   Name=APCDD1;
OS   Pelodiscus sinensis (Chinese softshell turtle) (Trionyx sinensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Trionychia;
OC   Trionychidae; Pelodiscus.
OX   NCBI_TaxID=13735;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15642085; DOI=10.1111/j.1525-142x.2005.05002.x;
RA   Kuraku S., Usuda R., Kuratani S.;
RT   "Comprehensive survey of carapacial ridge-specific genes in turtle implies
RT   co-option of some regulatory genes in carapace evolution.";
RL   Evol. Dev. 7:3-17(2005).
CC   -!- FUNCTION: Negative regulator of the Wnt signaling pathway. Inhibits Wnt
CC       signaling in a cell-autonomous manner and functions upstream of beta-
CC       catenin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in both the mesenchyme and the ectoderm
CC       of the carapacial ridge. {ECO:0000269|PubMed:15642085}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in specific regions in the limb buds of
CC       stage 13 embryos. {ECO:0000269|PubMed:15642085}.
CC   -!- SIMILARITY: Belongs to the APCDD1 family. {ECO:0000305}.
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DR   EMBL; AB124565; BAD74115.1; -; mRNA.
DR   RefSeq; NP_001273819.1; NM_001286890.1.
DR   AlphaFoldDB; Q5R2J4; -.
DR   STRING; 13735.ENSPSIP00000011522; -.
DR   GeneID; 102450692; -.
DR   KEGG; pss:102450692; -.
DR   CTD; 147495; -.
DR   eggNOG; ENOG502QQ0C; Eukaryota.
DR   HOGENOM; CLU_035648_0_0_1; -.
DR   OrthoDB; 613671at2759; -.
DR   Proteomes; UP000007267; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; TAS:AgBase.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0017147; F:Wnt-protein binding; ISS:UniProtKB.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR042425; APCDD1.
DR   InterPro; IPR029405; APCDD1_dom.
DR   PANTHER; PTHR31021; PTHR31021; 1.
DR   Pfam; PF14921; APCDDC; 2.
DR   SMART; SM01352; APCDDC; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Wnt signaling pathway.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..515
FT                   /note="Protein APCDD1"
FT                   /id="PRO_0000395839"
FT   TOPO_DOM        27..495
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        496..513
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        514..515
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          437..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        168
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        319
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   515 AA;  58924 MW;  2A9DFBC82FF71F28 CRC64;
     MSLPCCGRVR YLLLALLLHG LGEGSALLHP DSRSHPRSLE KSAWRAFKES QCHHMLKHLH
     NGARITVQMP PSIEGHWVST GCEVRSGPEF ITRSYRFYHN NTFKAYQFYY GGNRCTNPTY
     TLVIRGKIRL RQASWIIRGG TEADYQLHNV QIISHSEAVA EKLSQLVNRT CPGFVPGNSP
     WEQDVSYNLW REENGCECTR ALNFAMHELQ LIRVEKQYLH HNLDHLVEEL FLGDIHTDAT
     QRMYYRPSSY QPPLQNAKNH DHSCIACRII YRSDEHHPPI LPPKADLTIG LHGEWVSQRC
     EVRPEVLFLT RHFIFHDNNN TWEGHYYHYS DPICKHPTFT IYAKGRYSRG VHSSKVMGGT
     EFVFKVNHMK VTPMDIATAS LLNVFNGNEC GAEGSWQVGV QQDVTHTNGC VALGIRLPHT
     EYEIFKMEQN ARGSYLLYNG QRPSDGSSPD RPEKRATSYQ MPLVQCASSA PRPEESAEEN
     KIGRYSSRAP KKDSSVFMLT LMLFICTGSH WNIHS