ID   APCD1_XENTR             Reviewed;         510 AA.
AC   Q6DF34;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Protein APCDD1;
DE   AltName: Full=Adenomatosis polyposis coli down-regulated 1 protein homolog;
DE   Flags: Precursor;
GN   Name=apcdd1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of the Wnt signaling pathway. Inhibits Wnt
CC       signaling in a cell-autonomous manner and functions upstream of beta-
CC       catenin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the APCDD1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC076909; AAH76909.1; -; mRNA.
DR   RefSeq; NP_001005044.1; NM_001005044.1.
DR   AlphaFoldDB; Q6DF34; -.
DR   STRING; 8364.ENSXETP00000056413; -.
DR   PaxDb; Q6DF34; -.
DR   DNASU; 448576; -.
DR   Ensembl; ENSXETT00000097280; ENSXETP00000094972; ENSXETG00000026893.
DR   GeneID; 448576; -.
DR   KEGG; xtr:448576; -.
DR   CTD; 147495; -.
DR   Xenbase; XB-GENE-5762130; apcdd1.
DR   eggNOG; ENOG502QQ0C; Eukaryota.
DR   InParanoid; Q6DF34; -.
DR   OrthoDB; 613671at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026893; Expressed in neurula embryo and 13 other tissues.
DR   ExpressionAtlas; Q6DF34; differential.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0017147; F:Wnt-protein binding; ISS:UniProtKB.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR042425; APCDD1.
DR   InterPro; IPR029405; APCDD1_dom.
DR   PANTHER; PTHR31021; PTHR31021; 1.
DR   Pfam; PF14921; APCDDC; 2.
DR   SMART; SM01352; APCDDC; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Wnt signaling pathway.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..510
FT                   /note="Protein APCDD1"
FT                   /id="PRO_0000395841"
FT   TOPO_DOM        24..483
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        484..504
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        505..510
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        310
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        313
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   510 AA;  58568 MW;  5BAECEDB80277CB5 CRC64;
     MEPRLISCFL PLITFLGVGQ SSALTLPDNR LHPQSLEKNP WREFQCQHML KHLHNGARVT
     VQMPPNIEGH WVSMGCEVRS GPEFITRSYR FYNNNTFKAY QYYYGNNHCT NPTYTLVTRG
     KIRLRQASWI IRGGTEADYQ LHNVQVIPHS ESVAEKLTWL INHTCPGFVP GDMPWEPGIS
     YDLWREESGF KCTKALNFAM HELQLIRVEK QYMHHNLDHL VEELFLGDIH TDPTQRMYYR
     PSSYQPPLQN AKNLNQNCVA CRTILHSDEY HPPILPAKAD LPVGLHGEWV SQRCEVRPEV
     LFLTRHFIFN DSNHTWEGFY YHYSDPICKH PSFTIYAKGR YSRGVYSSKV MGGTEFVFKV
     SHMKVTPMDF ATASLLNVFN GDECGAEGSW KVGVEQDVTH TNGCVALGIK LPHTEYELFR
     MEQDNRGRYL LYNGQRPSDG SSPDRPEKRA TSYQVPLVQC TSSSLNPEGA HDGQQKSQSR
     NSAAGHIFLY LFSNIFLLFI CTLLHLEILS