APCDL_HUMAN
ID APCDL_HUMAN Reviewed; 501 AA.
AC Q8NCL9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Protein APCDD1-like;
DE AltName: Full=Adenomatosis polyposis coli down-regulated 1 protein-like;
DE Flags: Precursor;
GN Name=APCDD1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NCL9; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-12904424, EBI-2680384;
CC Q8NCL9; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-12904424, EBI-713304;
CC Q8NCL9; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-12904424, EBI-7850136;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK074647; BAC11111.1; -; mRNA.
DR EMBL; AL118513; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC101760; AAI01761.1; -; mRNA.
DR EMBL; BC101758; AAI01759.1; -; mRNA.
DR CCDS; CCDS13467.1; -.
DR RefSeq; NP_001291716.1; NM_001304787.1.
DR RefSeq; NP_699191.1; NM_153360.2.
DR AlphaFoldDB; Q8NCL9; -.
DR BioGRID; 127892; 3.
DR IntAct; Q8NCL9; 3.
DR STRING; 9606.ENSP00000360191; -.
DR GlyGen; Q8NCL9; 1 site.
DR iPTMnet; Q8NCL9; -.
DR PhosphoSitePlus; Q8NCL9; -.
DR BioMuta; APCDD1L; -.
DR DMDM; 74751192; -.
DR MassIVE; Q8NCL9; -.
DR PaxDb; Q8NCL9; -.
DR PeptideAtlas; Q8NCL9; -.
DR PRIDE; Q8NCL9; -.
DR ProteomicsDB; 72905; -.
DR Antibodypedia; 76481; 44 antibodies from 5 providers.
DR DNASU; 164284; -.
DR Ensembl; ENST00000371149.8; ENSP00000360191.3; ENSG00000198768.11.
DR GeneID; 164284; -.
DR KEGG; hsa:164284; -.
DR MANE-Select; ENST00000371149.8; ENSP00000360191.3; NM_153360.3; NP_699191.1.
DR UCSC; uc002xze.2; human.
DR CTD; 164284; -.
DR GeneCards; APCDD1L; -.
DR HGNC; HGNC:26892; APCDD1L.
DR HPA; ENSG00000198768; Tissue enhanced (salivary).
DR neXtProt; NX_Q8NCL9; -.
DR OpenTargets; ENSG00000198768; -.
DR PharmGKB; PA145149831; -.
DR VEuPathDB; HostDB:ENSG00000198768; -.
DR eggNOG; ENOG502QQ0C; Eukaryota.
DR GeneTree; ENSGT00640000091492; -.
DR HOGENOM; CLU_035648_1_0_1; -.
DR InParanoid; Q8NCL9; -.
DR OMA; NRSWEGY; -.
DR OrthoDB; 613671at2759; -.
DR PhylomeDB; Q8NCL9; -.
DR TreeFam; TF329491; -.
DR PathwayCommons; Q8NCL9; -.
DR SignaLink; Q8NCL9; -.
DR BioGRID-ORCS; 164284; 12 hits in 1069 CRISPR screens.
DR ChiTaRS; APCDD1L; human.
DR GenomeRNAi; 164284; -.
DR Pharos; Q8NCL9; Tdark.
DR PRO; PR:Q8NCL9; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8NCL9; protein.
DR Bgee; ENSG00000198768; Expressed in vena cava and 99 other tissues.
DR ExpressionAtlas; Q8NCL9; baseline and differential.
DR Genevisible; Q8NCL9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0017147; F:Wnt-protein binding; IEA:InterPro.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR InterPro; IPR042425; APCDD1.
DR InterPro; IPR029405; APCDD1_dom.
DR PANTHER; PTHR31021; PTHR31021; 1.
DR Pfam; PF14921; APCDDC; 2.
DR SMART; SM01352; APCDDC; 2.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..501
FT /note="Protein APCDD1-like"
FT /id="PRO_0000264234"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 30
FT /note="C -> R (in dbSNP:rs3946003)"
FT /id="VAR_029625"
FT VARIANT 80
FT /note="Y -> H (in dbSNP:rs7265854)"
FT /id="VAR_029626"
FT VARIANT 83
FT /note="R -> Q (in dbSNP:rs7265902)"
FT /id="VAR_050668"
FT VARIANT 261
FT /note="R -> C (in dbSNP:rs16981999)"
FT /id="VAR_029627"
SQ SEQUENCE 501 AA; 55635 MW; D7B18440E789EEBF CRC64;
MPAAMLPYAC VLVLLGAHTA PAAGEAGGSC LRWEPHCQQP LPDRVPSTAI LPPRLNGPWI
STGCEVRPGP EFLTRAYTFY PSRLFRAHQF YYEDPFCGEP AHSLLVKGKV RLRRASWVTR
GATEADYHLH KVGIVFHSRR ALVDVTGRLN QTRAGRDCAR RLPPARAWLP GALYELRSAR
AQGDCLEALG LTMHELSLVR VQRRLQPQPR ASPRLVEELY LGDIHTDPAE RRHYRPTGYQ
RPLQSALHHV QPCPACGLIA RSDVHHPPVL PPPLALPLHL GGWWVSSGCE VRPAVLFLTR
LFTFHGHSRS WEGYYHHFSD PACRQPTFTV YAAGRYTRGT PSTRVRGGTE LVFEVTRAHV
TPMDQVTTAM LNFSEPSSCG GAGAWSMGTE RDVTATNGCL PLGIRLPHVE YELFKMEQDP
LGQSLLFIGQ RPTDGSSPDT PEKRPTSYQA PLVLCHGEAP DFSRPPQHRP SLQKHPSTGG
LHIAPFPLLP LVLGLAFLHW L
