APC_XENLA
ID APC_XENLA Reviewed; 2829 AA.
AC P70039; P79934;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Adenomatous polyposis coli homolog;
DE Short=Protein APC;
GN Name=apc;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Vleminckx K., Wong E., Guger K., Gumbiner B.M.;
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes rapid degradation of CTNNB1 and participates in Wnt
CC signaling as a negative regulator. {ECO:0000250}.
CC -!- INTERACTION:
CC P70039; Q9YGY0: axin1; NbExp=2; IntAct=EBI-8069633, EBI-1037449;
CC P70039; Q9ULH1: ASAP1; Xeno; NbExp=5; IntAct=EBI-8069633, EBI-346622;
CC P70039; O43150: ASAP2; Xeno; NbExp=4; IntAct=EBI-8069633, EBI-310968;
CC P70039; O15169: AXIN1; Xeno; NbExp=2; IntAct=EBI-8069633, EBI-710484;
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000305}.
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DR EMBL; U64442; AAB41671.1; -; mRNA.
DR RefSeq; NP_001084351.1; NM_001090882.1.
DR SMR; P70039; -.
DR BioGRID; 100780; 5.
DR IntAct; P70039; 10.
DR MINT; P70039; -.
DR MaxQB; P70039; -.
DR PRIDE; P70039; -.
DR GeneID; 399455; -.
DR KEGG; xla:399455; -.
DR CTD; 399455; -.
DR Xenbase; XB-GENE-480859; apc.L.
DR PRO; PR:P70039; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 399455; Expressed in egg cell and 19 other tissues.
DR GO; GO:0030877; C:beta-catenin destruction complex; ISS:UniProtKB.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0008013; F:beta-catenin binding; ISS:UniProtKB.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0019887; F:protein kinase regulator activity; ISS:UniProtKB.
DR GO; GO:0016477; P:cell migration; IEA:InterPro.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; ISS:UniProtKB.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0065003; P:protein-containing complex assembly; ISS:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR026836; APC.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR032038; APC_N.
DR InterPro; IPR036149; APC_N_sf.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009232; EB1-bd.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607; PTHR12607; 1.
DR PANTHER; PTHR12607:SF11; PTHR12607:SF11; 1.
DR Pfam; PF05972; APC_15aa; 2.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF16689; APC_N_CC; 1.
DR Pfam; PF05923; APC_r; 7.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF00514; Arm; 1.
DR Pfam; PF05937; EB1_binding; 1.
DR Pfam; PF05924; SAMP; 3.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF58050; SSF58050; 1.
DR SUPFAM; SSF82931; SSF82931; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome; Repeat; Wnt signaling pathway.
FT CHAIN 1..2829
FT /note="Adenomatous polyposis coli homolog"
FT /id="PRO_0000064630"
FT REPEAT 343..384
FT /note="ARM 1"
FT REPEAT 462..504
FT /note="ARM 2"
FT REPEAT 516..555
FT /note="ARM 3"
FT REPEAT 559..599
FT /note="ARM 4"
FT REPEAT 603..646
FT /note="ARM 5"
FT REPEAT 652..691
FT /note="ARM 6"
FT REPEAT 694..733
FT /note="ARM 7"
FT REGION 80..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 901..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1278..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1424..1469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1533..1612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1657..1718
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1754..1842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1875..1950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1963..2012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2041..2069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2154..2627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2686..2829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 4..58
FT /evidence="ECO:0000255"
FT COILED 133..244
FT /evidence="ECO:0000255"
FT COILED 1545..1578
FT /evidence="ECO:0000255"
FT COMPBIAS 245..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..300
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..877
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..915
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1049
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1096..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1131..1183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1337..1380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1538..1564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1597..1611
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1657..1680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1681..1701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1754..1778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1809..1837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1875..1901
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1924..1938
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1981..1999
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2169..2190
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2198..2225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2256..2274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2282..2423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2458..2491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2512..2527
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2551..2574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2726..2799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2809..2829
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2829 AA; 310882 MW; 8A2BABDB7706E496 CRC64;
MAAASYDQLV KQVEALTMEN TNLRQELEDN SNHLTKLETE ATNMKEVLKQ LQGSIEDEAM
ASSGPIDLLE RFKDLNLDSS NIPAGKARPK MSMRSYGSRE GSLSGHSGEC SPVPVGSFQR
RGLLNGSRES AGYMEELEKE RLLLIAEHEK EEKEKRWYYA QLQNLTKRID SLPLTENFSM
QTDMTRRQLE YEARQIRAAM EEQLGTCQDM EKRVQTRVGK IHQIEEEILR IRQLLQSQVA
EAAERTPQSK HDAGSRDAEK LPDGQGTSEI TASGNVGSGQ GSSSRADHDT TSVMSSNSTY
SVPRRLTSHL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCIAMR QSGCLPLLIQ
LLHGNDKDSV LLGNSRGSKE ARASGSAALD NIIHSQPDDK RGRREIRVLH LLEQIRAYCE
TCWEWQEAHE QGMDQDKNPM PAPVDHQICP AVCVLMKLSF DEEHRHAMNE LGGLQAIAEL
LQVDCEMYGL INDHYSVTLR RYAGMALTNL TFGDVANKAT LCSMKSCMRA LVAQLKSESE
DLQQVIASVL RNLSWRADVN SKKTLREVGS VKALMECALD VKKESTLKSV LSALWNLSAH
CTENKADICS VDGALAFLVS TLTYRSQTNT LAIIESGGGI LRNVSSLIAT NEDHRQILRE
NNCLQTLLQH LKSHSLTIVS NACGTLWNLS ARNAKDQEGL WDMGAVSMLK NLIHSKHKMI
AMGSAAALRN LMANRPAKYK DANIMSPGSS VPSLHVRKQK ALEAELDAQH LSETFDNIDN
LSPKTTHRNK QRHKQNLCSE YALDSSRHDD SICRSDNFSI GNLTVLSPYI NTTVLPGSSS
PRPTMDGSRP EKDRERTAGL GNYHSTTESS GNSSKRIGIQ LSTTAQISKV MDEVSNIHLV
QENRSSGSAS EMHCMSDERN SQRKPSSNHP QSNPFTFTKA ESSTRGCPVA FMKMEYKMAS
NDSLNSVSST EGYGKRGQVK PSVESYSEDD ESKFFSYGQY PAGLAHKIQS ANHMDDNDTE
LDTPINYSLK YSDEQLNSGR QSPTQNERWS RPKHIIDSEM KQSEQRQPRT TKTTYSSYTE
NKEEKHKKFP PHFNQSENVP AYTRSRGANN QVDQSRVSSN LSNNSKASKP HCQVDDYDDD
KTTNFSERYS EEEQQEDETE RQNKYNIKAY ASEEHHGEQP IDYSRKYSTD VPSSAQKPSF
PYSNNSSKQK PKKEQVSSNS NTPTPSPNSN RQNQLHPNSA QSRPGLNRPK QIPNKPPSIN
QETIQTYCVE DTPICFSRGS SLSSLSSAED EIEGRERNSR GQESNNTLQI TEPKEISAVS
KDGAVNETRS SVHHTRTKNN RLQTSNISPS DSSRHKSVEF SSGAKSPSKS GAQTPKSPPE
HYVQETPLMF SRCTSGSSLD SFESHSIASS IASSVASEHM ISGIISPSDL PDSPGQTMPP
SRSKTPPPPQ TVQAKKDGSK PIVPDEERGK VAKTAVHSAI QRVQVLQEAD TLLHFATEST
PDGFSCASSL SALSLDEPYI QKDVQLKIMP PVLENDQGNK AEPEKEFIDN KAKKEDKRSE
QEKDMLDDTD DDIDILEECI ISAMPRKPSR KNKKVPQPTP GKPPPPVARK PSQLPVYKLL
SSQNRLQTQK HVNFTHSDDM PRVYCVEGTP INFSTATSLS DLTIESPPSE PTNDQPNTDS
LSTDLEKRDT IPTEGRSTDD TDASKPLNPT TVLDEDKAEE GDILAECIHS AMPKGKSHKP
YRVKKIMDQI NHTSAATSSG NSRSMQETDK NKPTSPVKPM PQSIGFKERL KKNTELKLNP
NSENQYCDPR KPSSKKPSKV ANEKIPNNEE RTKGFAFDSP HHYTPIEGTP YCFSRNDSLS
SLDFEDDDID LSKEKAELRK EKGTKDTDQK VKYKHENRAI NPMGKQDQTG PKSLGGRDQP
KALVQKPTSF SSAAKGTQDR GGATDEKMEN FAIENTPVCF SRNSSLSSLS DIDQENNNKE
TEPLKQTGTS ETQLGLRRPQ TSGYAPKSFH VEDTPVCFSR NSSLSSLSID SEDDLLQECI
SSAMPKKRKP SKIKNEVGKS RSNSVGGILA EEPDLTLDLR DIQSPDSENA FSPDSENFDW
KAIQEGANSI VSRLHQAAAA GSLSRQGSSD SDSILSLKSG ISLGSPFHLT LDKEEKTITS
NKGPKILKPA EKSALENKKT EEEPKGIKGG KKVYKSLITG KSRSSSDFSS HCKQSVQTNM
PSISRGRTMI HIPGVRASSP STSPVSKKGP VFKNVPSKGS NENPSSSSSP KGTKPLKSEL
VYGSRPSSTP GGSSKGNSRS GSRDSASSRP SPQPLSRPLQ SPGRNSISPG KNGISPPNKF
SQLPRTTSPS TASTKSSGSG RMSYTSPGRQ LSQPNLSKQS GLPKTHSSIP RSESASKSLN
QNVNTGSNKK VELSRMSSTK SSGSESDRSE RPALVRQSTF IKEAPSPTLR RKLEESASFE
SLSSSSRADS PPRSQTQTPA LSPSLPDMAL STHSIQAGGW RKMPPNLNPA AEHGDSRRRH
DISRSHSESP SRLPITRSGT WKREHSKHSS SLPRVSTWRR TGSSSSILSA SSESSEKAKS
EDEKQQVCSF PGPRSECSSS AKGTWRKIKE SEILETPSNG SSSTIAESNC SLESKTLVYQ
MAPAVSKTED VWVRIEDCPI NNPRSGRSPT GNSPPVIDNV LDQGQKEEAA KDCHTRHNSG
NGNVPLLENR QKSFIKVDGL DTKGTDPKSL INNQQETNEN TVAERTAFSS SSSSKHSSPS
GTVAARVTPF NYNPSPRKSN GENSTSRPSQ IPTPVTNSTK KRDSKTETTD SSGSQSPKRH
SGSYLVTSV
