ID   IF20A_XENLA             Reviewed;         132 AA.
AC   Q90WZ0; Q5PQ52;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Intraflagellar transport protein 20 homolog A;
GN   Name=ift20-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=11916979; DOI=10.1083/jcb.200107108;
RA   Pazour G.J., Baker S.A., Deane J.A., Cole D.G., Dickert B.L.,
RA   Rosenbaum J.L., Witman G.B., Besharse J.C.;
RT   "The intraflagellar transport protein, IFT88, is essential for vertebrate
RT   photoreceptor assembly and maintenance.";
RL   J. Cell Biol. 157:103-113(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ciliary process assembly. May play a role in the
CC       trafficking of ciliary membrane proteins from the Golgi complex to the
CC       cilium. Regulates the platelet-derived growth factor receptor-alpha
CC       (PDGFRA) signaling pathway. Plays an important role in spermatogenesis,
CC       particularly spermiogenesis, when germ cells form flagella.
CC       {ECO:0000250|UniProtKB:Q61025}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network
CC       {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q61025}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q61025}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q61025}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q61025}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q90WZ0-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q90WZ0-2; Sequence=VSP_020393;
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DR   EMBL; AY048114; AAL07274.1; -; mRNA.
DR   EMBL; BC087360; AAH87360.1; -; mRNA.
DR   RefSeq; NP_001082135.1; NM_001088666.1. [Q90WZ0-1]
DR   AlphaFoldDB; Q90WZ0; -.
DR   SMR; Q90WZ0; -.
DR   MaxQB; Q90WZ0; -.
DR   DNASU; 398244; -.
DR   GeneID; 398244; -.
DR   KEGG; xla:398244; -.
DR   CTD; 398244; -.
DR   Xenbase; XB-GENE-966393; ift20.L.
DR   OMA; TMAKQRQ; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 398244; Expressed in testis and 19 other tissues.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:2000583; P:regulation of platelet-derived growth factor receptor-alpha signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR   InterPro; IPR028172; FT20.
DR   PANTHER; PTHR31978; PTHR31978; 1.
DR   Pfam; PF14931; IFT20; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cilium biogenesis/degradation;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Differentiation; Golgi apparatus;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..132
FT                   /note="Intraflagellar transport protein 20 homolog A"
FT                   /id="PRO_0000249306"
FT   COILED          87..112
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         72..132
FT                   /note="AIGARNLLKSIAKQREAQQQQLYALIAEKKMQLERYRIEYDALCKVEAEQNE
FT                   FIDQFNLQK -> CVYFVKGNRCPELVKIYSKAKRSPAAATICLNSREENATRKVPNRI
FT                   RRSV (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_020393"
SQ   SEQUENCE   132 AA;  15328 MW;  B5069516DF48306D CRC64;
     MARDSLSDAG LHFDELNKLR ILDPDVSQQT TELKEECRDF VDKIGHFQKV VGGLIELVDE
     LAKETENEKM KAIGARNLLK SIAKQREAQQ QQLYALIAEK KMQLERYRIE YDALCKVEAE
     QNEFIDQFNL QK