IF27A_MOUSE
ID IF27A_MOUSE Reviewed; 90 AA.
AC Q8R412;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Interferon alpha-inducible protein 27-like protein 2A {ECO:0000305};
DE AltName: Full=Interferon-stimulated gene 12 protein {ECO:0000303|PubMed:12388728};
DE Short=ISG12 {ECO:0000303|PubMed:12388728};
DE Flags: Precursor;
GN Name=Ifi27l2a {ECO:0000312|MGI:MGI:1924183};
GN Synonyms=Ifi27, Isg12 {ECO:0000303|PubMed:12388728};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=12388728; DOI=10.1128/jvi.76.22.11688-11703.2002;
RA Labrada L., Liang X.H., Zheng W., Johnston C., Levine B.;
RT "Age-dependent resistance to lethal alphavirus encephalitis in mice:
RT analysis of gene expression in the central nervous system and
RT identification of a novel interferon-inducible protective gene, mouse
RT ISG12.";
RL J. Virol. 76:11688-11703(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION.
RX PubMed=14728724; DOI=10.1186/1471-2164-5-8;
RA Parker N., Porter A.C.G.;
RT "Identification of a novel gene family that includes the interferon-
RT inducible human genes 6-16 and ISG12.";
RL BMC Genomics 5:8-8(2004).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22427340; DOI=10.1161/circresaha.111.258814;
RA Papac-Milicevic N., Breuss J.M., Zaujec J., Ryban L., Plyushch T.,
RA Wagner G.A., Fenzl S., Dremsek P., Cabaravdic M., Steiner M., Glass C.K.,
RA Binder C.J., Uhrin P., Binder B.R.;
RT "The interferon stimulated gene 12 inactivates vasculoprotective functions
RT of NR4A nuclear receptors.";
RL Circ. Res. 110:E50-E63(2012).
CC -!- FUNCTION: May be involved in the interferon-induced negative regulation
CC of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the
CC enhancement of XPO1-mediated nuclear export of these nuclear receptors
CC (PubMed:22427340). Through the regulation of NR4A1 transcriptional
CC activity, may play a role in the vascular response to injury
CC (PubMed:22427340). {ECO:0000269|PubMed:22427340}.
CC -!- SUBUNIT: Homodimer (By similarity). Interacts with SKP2 (By
CC similarity). Interacts with NR4A1 (By similarity). May interact with
CC BCL2 (By similarity). {ECO:0000250|UniProtKB:P40305}.
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000305|PubMed:22427340}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- INDUCTION: Up-regulated by interferon (PubMed:22427340). Up-regulated
CC by vascular tissues injury (PubMed:22427340).
CC {ECO:0000269|PubMed:22427340}.
CC -!- DISRUPTION PHENOTYPE: Homozygous knockout mice exhibit no obvious
CC phenotype, having normal growth rates, survival, fertility and litter
CC sizes (PubMed:22427340). No organ pathology is detected
CC (PubMed:22427340). However, they display decreased restenosis, the
CC narrowing of blood vessels, upon vascular injury (PubMed:22427340).
CC {ECO:0000269|PubMed:22427340}.
CC -!- SIMILARITY: Belongs to the IFI6/IFI27 family. {ECO:0000305}.
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DR EMBL; AK160503; BAE35827.1; -; mRNA.
DR EMBL; AC154347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466549; EDL18827.1; -; Genomic_DNA.
DR EMBL; BC100588; AAI00589.1; -; mRNA.
DR EMBL; AY090098; AAM10443.1; -; mRNA.
DR EMBL; BN000231; CAE00398.1; -; mRNA.
DR CCDS; CCDS49153.1; -.
DR RefSeq; NP_084079.1; NM_029803.3.
DR AlphaFoldDB; Q8R412; -.
DR STRING; 10090.ENSMUSP00000054698; -.
DR PhosphoSitePlus; Q8R412; -.
DR PaxDb; Q8R412; -.
DR PRIDE; Q8R412; -.
DR DNASU; 76933; -.
DR Ensembl; ENSMUST00000055071; ENSMUSP00000054698; ENSMUSG00000079017.
DR GeneID; 76933; -.
DR KEGG; mmu:76933; -.
DR UCSC; uc007ovn.3; mouse.
DR CTD; 76933; -.
DR MGI; MGI:1924183; Ifi27l2a.
DR VEuPathDB; HostDB:ENSMUSG00000079017; -.
DR GeneTree; ENSGT00940000155018; -.
DR HOGENOM; CLU_142338_3_0_1; -.
DR InParanoid; Q8R412; -.
DR OMA; APLAIWG; -.
DR TreeFam; TF340510; -.
DR BioGRID-ORCS; 76933; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q8R412; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8R412; protein.
DR Bgee; ENSMUSG00000079017; Expressed in aorta tunica adventitia and 165 other tissues.
DR Genevisible; Q8R412; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007568; P:aging; IDA:MGI.
DR GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0009615; P:response to virus; IDA:MGI.
DR Gene3D; 6.10.110.10; -; 1.
DR InterPro; IPR009311; IFI6/IFI27-like.
DR InterPro; IPR038213; IFI6/IFI27-like_sf.
DR PANTHER; PTHR16932; PTHR16932; 1.
DR Pfam; PF06140; Ifi-6-16; 1.
PE 2: Evidence at transcript level;
KW Membrane; Nucleus; Reference proteome; Signal; Transcription;
KW Transcription regulation; Transmembrane; Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..90
FT /note="Interferon alpha-inducible protein 27-like protein
FT 2A"
FT /id="PRO_0000416107"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 90 AA; 7929 MW; E4EEE1E956031607 CRC64;
MLGTLFGSAI GGALAVAGAP VALAAMGFTG TGIAAASIAA KMMSAAAIAN GGGVAAGSLV
ATLQSAGVLG LSTSTNAILG AAGAAVGALL
