IF27B_MOUSE
ID IF27B_MOUSE Reviewed; 283 AA.
AC Q8VC49; Q6IEB6;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Interferon alpha-inducible protein 27-like protein 2B {ECO:0000305};
DE AltName: Full=Interferon-stimulated gene 12 protein B2 {ECO:0000303|PubMed:14728724};
DE Short=ISG12(b2) {ECO:0000303|PubMed:14728724};
DE Flags: Precursor;
GN Name=Ifi27l2b {ECO:0000312|MGI:MGI:1916390}; Synonyms=Isg12(b2);
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=14728724; DOI=10.1186/1471-2164-5-8;
RA Parker N., Porter A.C.G.;
RT "Identification of a novel gene family that includes the interferon-
RT inducible human genes 6-16 and ISG12.";
RL BMC Genomics 5:8-8(2004).
RN [5]
RP FUNCTION, SUBUNIT, INTERACTION WITH ADENINE NUCLEOTIDE TRANSLOCASE; BAK1
RP AND BAX, SUBCELLULAR LOCATION, INDUCTION, AND TRANSIT PEPTIDE.
RX PubMed=21151029; DOI=10.1038/cdd.2010.160;
RA Lu M.Y., Liao F.;
RT "Interferon-stimulated gene ISG12b2 is localized to the inner mitochondrial
RT membrane and mediates virus-induced cell death.";
RL Cell Death Differ. 18:925-936(2011).
CC -!- FUNCTION: Functions in the intrinsic apoptotic signaling pathway and
CC may have an interferon-induced antiviral activity.
CC {ECO:0000269|PubMed:21151029}.
CC -!- SUBUNIT: Homooligomer (PubMed:21151029). Interacts with BAK1
CC (PubMed:21151029). Interacts with BAX (PubMed:21151029). Interacts with
CC adenine nucleotide translocase (PubMed:21151029).
CC {ECO:0000269|PubMed:21151029}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:21151029}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- INDUCTION: Up-regulated by type-I interferon (PubMed:21151029). Up-
CC regulated by poly(I:C) (PubMed:21151029).
CC {ECO:0000269|PubMed:21151029}.
CC -!- SIMILARITY: Belongs to the IFI6/IFI27 family. {ECO:0000305}.
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DR EMBL; AC154347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466549; EDL18826.1; -; Genomic_DNA.
DR EMBL; BC021795; AAH21795.1; -; mRNA.
DR EMBL; BN000232; CAE00399.1; -; mRNA.
DR CCDS; CCDS26133.1; -.
DR RefSeq; NP_663424.1; NM_145449.2.
DR AlphaFoldDB; Q8VC49; -.
DR STRING; 10090.ENSMUSP00000041712; -.
DR MaxQB; Q8VC49; -.
DR PaxDb; Q8VC49; -.
DR PeptideAtlas; Q8VC49; -.
DR PRIDE; Q8VC49; -.
DR ProteomicsDB; 269375; -.
DR DNASU; 217845; -.
DR Ensembl; ENSMUST00000044687; ENSMUSP00000041712; ENSMUSG00000021208.
DR GeneID; 217845; -.
DR KEGG; mmu:217845; -.
DR UCSC; uc007ovv.1; mouse.
DR CTD; 217845; -.
DR MGI; MGI:1916390; Ifi27l2b.
DR VEuPathDB; HostDB:ENSMUSG00000021208; -.
DR eggNOG; ENOG502S85T; Eukaryota.
DR GeneTree; ENSGT00940000155018; -.
DR HOGENOM; CLU_983401_0_0_1; -.
DR InParanoid; Q8VC49; -.
DR OMA; KQRRDPT; -.
DR TreeFam; TF340510; -.
DR BioGRID-ORCS; 217845; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q8VC49; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8VC49; protein.
DR Bgee; ENSMUSG00000021208; Expressed in small intestine Peyer's patch and 75 other tissues.
DR Genevisible; Q8VC49; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0031966; C:mitochondrial membrane; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR GO; GO:0097190; P:apoptotic signaling pathway; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0097193; P:intrinsic apoptotic signaling pathway; IMP:UniProtKB.
DR Gene3D; 6.10.110.10; -; 2.
DR InterPro; IPR009311; IFI6/IFI27-like.
DR InterPro; IPR038213; IFI6/IFI27-like_sf.
DR PANTHER; PTHR16932; PTHR16932; 2.
DR Pfam; PF06140; Ifi-6-16; 2.
PE 1: Evidence at protein level;
KW Antiviral defense; Apoptosis; Immunity; Innate immunity; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..90
FT /note="Mitochondrion"
FT /evidence="ECO:0000305|PubMed:21151029"
FT CHAIN 91..283
FT /note="Interferon alpha-inducible protein 27-like protein
FT 2B"
FT /id="PRO_0000416108"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 90..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 27772 MW; CE325A06EC3B066C CRC64;
MKRKFVGAAI GGALAVAGAP VALSAVGFTG AGIAAGSIAA KMMSAAAIAN GGGIAAGGLV
ATLQSVGVLG LSTITNIILV AVGTATGARA EGSMGASREQ ESGPQDPPQE LQEPQEPPSC
KKQDLNLGKF VGAAIGGALA VAGAPIALSA VGFTGAGIAA GSIAAKMMSA AAIANGGGIA
AGGLVATLQS VGILGLSTST NIILGAVGAA TGATAAGAMG ACREQEPGLQ DLQQEPKEPQ
EPQELQKQQE PQEPQELQKQ QETQETQETQ ELQKTQEPPS YEK
