ID   IF2A_METJA              Reviewed;         266 AA.
AC   Q57581;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Translation initiation factor 2 subunit alpha;
DE   AltName: Full=aIF2-alpha;
DE   AltName: Full=eIF-2-alpha;
GN   Name=eif2a; OrderedLocusNames=MJ0117;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC       forming a ternary complex with GTP and initiator tRNA. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2-alpha family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98098.1; -; Genomic_DNA.
DR   PIR; E64314; E64314.
DR   AlphaFoldDB; Q57581; -.
DR   SMR; Q57581; -.
DR   STRING; 243232.MJ_0117; -.
DR   EnsemblBacteria; AAB98098; AAB98098; MJ_0117.
DR   KEGG; mja:MJ_0117; -.
DR   eggNOG; arCOG04107; Archaea.
DR   HOGENOM; CLU_033458_0_2_2; -.
DR   InParanoid; Q57581; -.
DR   OMA; DVNEHQR; -.
DR   PhylomeDB; Q57581; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   CDD; cd04452; S1_IF2_alpha; 1.
DR   Gene3D; 1.10.150.190; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.30.70.1130; -; 1.
DR   HAMAP; MF_00231; eIF_2_alpha; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   InterPro; IPR044126; S1_IF2_alpha.
DR   InterPro; IPR022964; TIF2_asu_arc.
DR   InterPro; IPR024055; TIF2_asu_C.
DR   InterPro; IPR024054; TIF2_asu_middle_sf.
DR   InterPro; IPR011488; TIF_2_asu.
DR   PANTHER; PTHR10602; PTHR10602; 1.
DR   Pfam; PF07541; EIF_2_alpha; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF110993; SSF110993; 1.
DR   SUPFAM; SSF116742; SSF116742; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding.
FT   CHAIN           1..266
FT                   /note="Translation initiation factor 2 subunit alpha"
FT                   /id="PRO_0000137394"
FT   DOMAIN          12..83
FT                   /note="S1 motif"
SQ   SEQUENCE   266 AA;  30485 MW;  31D2805A642D372A CRC64;
     MFIMRREFPE EGDIVIGTVK DVKPYGAFVE LLEYPGKEGM IHISEVTSGW VKNIRDHVKV
     GQRVVAKVLR VDERKGHIDL SLKRVTEQQK RAKVQEWKRF QRASKMLERA AEKLGKSLEE
     AWEEVGYLLE DEFGELYNAF ETMVIEGKEV LDDLEISEEW KNVLYEVAKE SIELTNVEVE
     GVIEMKSYAP DGIKQIKKAL TTALKANPYE DVEVKITYIG APKYRVVVIA PDYKSGEEVF
     KKVCEKAVAT IKKLGGEGTY YRESKK