IF2A_METTH
ID IF2A_METTH Reviewed; 262 AA.
AC O27363;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Translation initiation factor 2 subunit alpha;
DE AltName: Full=aIF2-alpha;
DE AltName: Full=eIF-2-alpha;
GN Name=eif2a; OrderedLocusNames=MTH_1308;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA. {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family. {ECO:0000305}.
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DR EMBL; AE000666; AAB85786.1; -; Genomic_DNA.
DR PIR; G69040; G69040.
DR AlphaFoldDB; O27363; -.
DR SMR; O27363; -.
DR STRING; 187420.MTH_1308; -.
DR PRIDE; O27363; -.
DR EnsemblBacteria; AAB85786; AAB85786; MTH_1308.
DR KEGG; mth:MTH_1308; -.
DR PATRIC; fig|187420.15.peg.1277; -.
DR HOGENOM; CLU_033458_0_2_2; -.
DR OMA; DVNEHQR; -.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 1.10.150.190; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.30.70.1130; -; 1.
DR HAMAP; MF_00231; eIF_2_alpha; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR022964; TIF2_asu_arc.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; PTHR10602; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; SSF110993; 1.
DR SUPFAM; SSF116742; SSF116742; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome; RNA-binding.
FT CHAIN 1..262
FT /note="Translation initiation factor 2 subunit alpha"
FT /id="PRO_0000137396"
FT DOMAIN 15..86
FT /note="S1 motif"
SQ SEQUENCE 262 AA; 29780 MW; D7324B76DAFD5AA7 CRC64;
MFFMVRRKNE WPEEGELVVG TVHKVLNYGA FATLEEYPGK EAFIHISEVS SGWVKNIRDF
VRENQKIVAR VLRVNPRKGH VDVSMKRIRE DQRTKKIQAW KIEQKAEKFL ELAARDLGKD
LDTAYEEVGY ELMDIFGDLY GAFETAAEEG EKSLIEEGVP EDWAAVITEV AKRNITPPEV
QITGYVDIKS YAPNGVEIIR KALKSAQDEG ITVQAVGAPR YRLIVKSTDY LKAEKQLKEA
AQKCIEIVEK EGGEGEFLRE LT
