APD1_YEAST
ID APD1_YEAST Reviewed; 316 AA.
AC P38281; D6VQE6;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Actin patches distal protein 1;
GN Name=APD1; OrderedLocusNames=YBR151W; ORFNames=YBR1201;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION.
RX PubMed=10628851; DOI=10.1007/pl00013817;
RA Entian K.-D., Schuster T., Hegemann J.H., Becher D., Feldmann H.,
RA Gueldener U., Goetz R., Hansen M., Hollenberg C.P., Jansen G., Kramer W.,
RA Klein S., Koetter P., Kricke J., Launhardt H., Mannhaupt G., Maierl A.,
RA Meyer P., Mewes W., Munder T., Niedenthal R.K., Ramezani Rad M.,
RA Roehmer A., Roemer A., Rose M., Schaefer B., Siegler M.-L., Vetter J.,
RA Wilhelm N., Wolf K., Zimmermann F.K., Zollner A., Hinnen A.;
RT "Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by
RT a systematic approach.";
RL Mol. Gen. Genet. 262:683-702(1999).
RN [5]
RP INDUCTION.
RX PubMed=11909958; DOI=10.1128/mcb.22.8.2642-2649.2002;
RA Le Crom S., Devaux F., Marc P., Zhang X., Moye-Rowley W.S., Jacq C.;
RT "New insights into the pleiotropic drug resistance network from genome-wide
RT characterization of the YRR1 transcription factor regulation system.";
RL Mol. Cell. Biol. 22:2642-2649(2002).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Required for normal localization of actin patches. Involved
CC in tolerance to sodium ions and hydrogen peroxide.
CC {ECO:0000269|PubMed:10628851}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- INDUCTION: Expression is controlled by the transcription factor YRR1.
CC {ECO:0000269|PubMed:11909958}.
CC -!- MISCELLANEOUS: Present with 2000 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the APD1 family. {ECO:0000305}.
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DR EMBL; Z36020; CAA85109.1; -; Genomic_DNA.
DR EMBL; AY693048; AAT93067.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07266.1; -; Genomic_DNA.
DR PIR; S46022; S46022.
DR RefSeq; NP_009709.1; NM_001178499.1.
DR AlphaFoldDB; P38281; -.
DR SMR; P38281; -.
DR BioGRID; 32850; 34.
DR IntAct; P38281; 4.
DR MINT; P38281; -.
DR STRING; 4932.YBR151W; -.
DR MaxQB; P38281; -.
DR PaxDb; P38281; -.
DR PRIDE; P38281; -.
DR EnsemblFungi; YBR151W_mRNA; YBR151W; YBR151W.
DR GeneID; 852448; -.
DR KEGG; sce:YBR151W; -.
DR SGD; S000000355; APD1.
DR VEuPathDB; FungiDB:YBR151W; -.
DR eggNOG; ENOG502QT0V; Eukaryota.
DR GeneTree; ENSGT00940000176686; -.
DR HOGENOM; CLU_033921_1_0_1; -.
DR InParanoid; P38281; -.
DR OMA; RPEDCEG; -.
DR BioCyc; YEAST:G3O-29102-MON; -.
DR PRO; PR:P38281; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38281; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR CDD; cd03062; TRX_Fd_Sucrase; 1.
DR InterPro; IPR009737; Aim32/Apd1-like.
DR InterPro; IPR030108; Apd1-like.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR31902; PTHR31902; 1.
DR PANTHER; PTHR31902:SF10; PTHR31902:SF10; 1.
DR Pfam; PF06999; Suc_Fer-like; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..316
FT /note="Actin patches distal protein 1"
FT /id="PRO_0000202497"
SQ SEQUENCE 316 AA; 35759 MW; 23A1BD4DD6C34CFC CRC64;
MAFLNIFKQK RGDEASQLSA KGREEISQSI KICKSDDAAN EHSCSGDCKT EIEEGEQAFA
KLKIEHETPL LNSSKTPKIH FVVPTSQIDW QHDACLEDPK SVQYKISQWC DKNSAKFSNV
GTGKTLNCAV SSLPKDIMDI DVMRGTKNNV LILPYFIWLN DLRSDDVEAT LDGLVPDLLD
ENISREKLLE TRPNVAVARE RAFVFICSHT TRDKRCGITA PYLKKVFDSK LQEHGLYRDN
SDYRAEGVKI AFVNHVGGHK FAANVQIYLR NPNTLIWLGR VTPTIVPSIV EHLIVPEEPT
LPFPEKVRCI KKYQSW
