IF2A_PYRAB
ID IF2A_PYRAB Reviewed; 275 AA.
AC Q9V0E4; G8ZH56;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Translation initiation factor 2 subunit alpha;
DE AltName: Full=aIF2-alpha;
DE AltName: Full=eIF-2-alpha;
GN Name=eif2a; Synonyms=aif2A; OrderedLocusNames=PYRAB08460; ORFNames=PAB0568;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA. {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family. {ECO:0000305}.
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DR EMBL; AJ248285; CAB49760.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE70251.1; -; Genomic_DNA.
DR PIR; G75130; G75130.
DR RefSeq; WP_010867969.1; NC_000868.1.
DR PDB; 1YZ6; X-ray; 3.37 A; A=2-275.
DR PDB; 1YZ7; X-ray; 2.26 A; A=89-275.
DR PDBsum; 1YZ6; -.
DR PDBsum; 1YZ7; -.
DR AlphaFoldDB; Q9V0E4; -.
DR SMR; Q9V0E4; -.
DR STRING; 272844.PAB0568; -.
DR EnsemblBacteria; CAB49760; CAB49760; PAB0568.
DR GeneID; 1496195; -.
DR KEGG; pab:PAB0568; -.
DR PATRIC; fig|272844.11.peg.895; -.
DR eggNOG; arCOG04107; Archaea.
DR HOGENOM; CLU_033458_0_2_2; -.
DR OMA; DVNEHQR; -.
DR OrthoDB; 84684at2157; -.
DR PhylomeDB; Q9V0E4; -.
DR EvolutionaryTrace; Q9V0E4; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 1.10.150.190; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.30.70.1130; -; 1.
DR HAMAP; MF_00231; eIF_2_alpha; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR022964; TIF2_asu_arc.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; PTHR10602; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; SSF110993; 1.
DR SUPFAM; SSF116742; SSF116742; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50126; S1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Initiation factor; Protein biosynthesis; RNA-binding.
FT CHAIN 1..275
FT /note="Translation initiation factor 2 subunit alpha"
FT /id="PRO_0000137397"
FT DOMAIN 12..83
FT /note="S1 motif"
FT STRAND 14..23
FT /evidence="ECO:0007829|PDB:1YZ6"
FT STRAND 26..31
FT /evidence="ECO:0007829|PDB:1YZ6"
FT STRAND 38..42
FT /evidence="ECO:0007829|PDB:1YZ6"
FT HELIX 43..45
FT /evidence="ECO:0007829|PDB:1YZ6"
FT STRAND 47..49
FT /evidence="ECO:0007829|PDB:1YZ6"
FT HELIX 54..56
FT /evidence="ECO:0007829|PDB:1YZ6"
FT STRAND 63..72
FT /evidence="ECO:0007829|PDB:1YZ6"
FT TURN 73..76
FT /evidence="ECO:0007829|PDB:1YZ6"
FT STRAND 77..84
FT /evidence="ECO:0007829|PDB:1YZ6"
FT HELIX 92..113
FT /evidence="ECO:0007829|PDB:1YZ7"
FT HELIX 118..124
FT /evidence="ECO:0007829|PDB:1YZ7"
FT HELIX 126..133
FT /evidence="ECO:0007829|PDB:1YZ7"
FT HELIX 136..146
FT /evidence="ECO:0007829|PDB:1YZ7"
FT HELIX 148..150
FT /evidence="ECO:0007829|PDB:1YZ7"
FT HELIX 159..170
FT /evidence="ECO:0007829|PDB:1YZ7"
FT STRAND 176..185
FT /evidence="ECO:0007829|PDB:1YZ7"
FT HELIX 191..207
FT /evidence="ECO:0007829|PDB:1YZ7"
FT STRAND 209..211
FT /evidence="ECO:0007829|PDB:1YZ6"
FT STRAND 213..218
FT /evidence="ECO:0007829|PDB:1YZ7"
FT STRAND 223..232
FT /evidence="ECO:0007829|PDB:1YZ7"
FT HELIX 233..253
FT /evidence="ECO:0007829|PDB:1YZ7"
FT STRAND 257..261
FT /evidence="ECO:0007829|PDB:1YZ7"
SQ SEQUENCE 275 AA; 31912 MW; B2659F3A49879B4F CRC64;
MPRRAREYPE EGEFVVATVK RIHNYGAFLE LDEYPGKEAF MHISEVASTW VRNIRDYLKE
GQKVVAKVIR VDPRKGHIDL SLRRVTQQQR KAKLQEFKRA QKAENLLKLA AEKLGKDFET
AWREVWVPLE EEWGEVYAAF EDAAKDGIDV LKGHVPDEWL PVLKEIIDNY VEVPTVTIDA
EFEITVPKPN GVEIIKEALI RARDRANKEK DVEVKFTYLG APRYRIDITA PDYYKAEEVL
ESIAEEILRV IKEAGGEATL LRKEKRIKKV KKRKK