IF2A_THEVO
ID IF2A_THEVO Reviewed; 254 AA.
AC Q97BP2;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Translation initiation factor 2 subunit alpha {ECO:0000255|HAMAP-Rule:MF_00231};
DE AltName: Full=aIF2-alpha {ECO:0000255|HAMAP-Rule:MF_00231};
DE AltName: Full=eIF-2-alpha {ECO:0000255|HAMAP-Rule:MF_00231};
GN Name=eif2a {ECO:0000255|HAMAP-Rule:MF_00231}; OrderedLocusNames=TV0413;
GN ORFNames=TVG0401470;
OS Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS 15438 / GSS1).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT Thermoplasma volcanium.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA.
CC {ECO:0000255|HAMAP-Rule:MF_00231}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000255|HAMAP-Rule:MF_00231}.
CC -!- SIMILARITY: Belongs to the eIF-2-alpha family. {ECO:0000255|HAMAP-
CC Rule:MF_00231}.
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DR EMBL; BA000011; BAB59555.1; -; Genomic_DNA.
DR RefSeq; WP_010916670.1; NC_002689.2.
DR AlphaFoldDB; Q97BP2; -.
DR SMR; Q97BP2; -.
DR STRING; 273116.14324628; -.
DR EnsemblBacteria; BAB59555; BAB59555; BAB59555.
DR GeneID; 1440928; -.
DR KEGG; tvo:TVG0401470; -.
DR eggNOG; arCOG04107; Archaea.
DR HOGENOM; CLU_033458_0_2_2; -.
DR OMA; DVNEHQR; -.
DR OrthoDB; 84684at2157; -.
DR PhylomeDB; Q97BP2; -.
DR Proteomes; UP000001017; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd04452; S1_IF2_alpha; 1.
DR Gene3D; 1.10.150.190; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 3.30.70.1130; -; 1.
DR HAMAP; MF_00231; eIF_2_alpha; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR022967; S1_dom.
DR InterPro; IPR003029; S1_domain.
DR InterPro; IPR044126; S1_IF2_alpha.
DR InterPro; IPR022964; TIF2_asu_arc.
DR InterPro; IPR024055; TIF2_asu_C.
DR InterPro; IPR024054; TIF2_asu_middle_sf.
DR InterPro; IPR011488; TIF_2_asu.
DR PANTHER; PTHR10602; PTHR10602; 1.
DR Pfam; PF07541; EIF_2_alpha; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF110993; SSF110993; 1.
DR SUPFAM; SSF116742; SSF116742; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; RNA-binding.
FT CHAIN 1..254
FT /note="Translation initiation factor 2 subunit alpha"
FT /id="PRO_0000137405"
FT DOMAIN 10..81
FT /note="S1 motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00231"
SQ SEQUENCE 254 AA; 28831 MW; C6EB019E44BB52CF CRC64;
MNIKLLPEVG DLVVVKITEV KNFGANGILE EYPGVEGYIH ISEVATGWVK HIRSYLREGQ
RVVCKVINVN QERKNVDLSL KRVNQHQSRE KIAEWKNEQK ADKLFEIVCS KLNKDLEACK
KEFGVRLVEL YGTLFAAFES AAAAEGEWLP DINGDWKDTF VEVAKENITI PEVSVAGYFE
AYSLASDGVE KIKEVLTIPP EIGKAELEYV GAPRYRIVVR DKDYKKAEET LKKIVQSVTD
KAKKLQVELE FSRQ
