IF2B_HALSA
ID IF2B_HALSA Reviewed; 132 AA.
AC Q9HQ97;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Translation initiation factor 2 subunit beta {ECO:0000255|HAMAP-Rule:MF_00232};
DE AltName: Full=aIF2-beta {ECO:0000255|HAMAP-Rule:MF_00232};
DE AltName: Full=eIF-2-beta {ECO:0000255|HAMAP-Rule:MF_00232};
GN Name=eif2b {ECO:0000255|HAMAP-Rule:MF_00232}; OrderedLocusNames=VNG_1262G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA.
CC {ECO:0000255|HAMAP-Rule:MF_00232}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000255|HAMAP-Rule:MF_00232}.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family. {ECO:0000255|HAMAP-
CC Rule:MF_00232}.
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DR EMBL; AE004437; AAG19619.1; -; Genomic_DNA.
DR PIR; G84281; G84281.
DR RefSeq; WP_010902915.1; NC_002607.1.
DR AlphaFoldDB; Q9HQ97; -.
DR SMR; Q9HQ97; -.
DR STRING; 64091.VNG_1262G; -.
DR PaxDb; Q9HQ97; -.
DR EnsemblBacteria; AAG19619; AAG19619; VNG_1262G.
DR GeneID; 5952891; -.
DR GeneID; 62886758; -.
DR KEGG; hal:VNG_1262G; -.
DR PATRIC; fig|64091.14.peg.969; -.
DR HOGENOM; CLU_026663_3_1_2; -.
DR InParanoid; Q9HQ97; -.
DR OMA; NVKHHKS; -.
DR OrthoDB; 96453at2157; -.
DR PhylomeDB; Q9HQ97; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR HAMAP; MF_00232; eIF_2_beta; 1.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR004458; TIF2_bsu_arc.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR PANTHER; PTHR23001; PTHR23001; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SUPFAM; SSF100966; SSF100966; 1.
DR SUPFAM; SSF75689; SSF75689; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..132
FT /note="Translation initiation factor 2 subunit beta"
FT /id="PRO_0000137419"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 132 AA; 14683 MW; 8745F0D9ED158E36 CRC64;
MDYEEQLDRA MDEKPDVTGS ETRFEVPDPN VRKEGNVTVY ENFQATLDAL SRTQDHVLKF
LQNEVGTSAS IDESGRARLT GEFGQRRVSD TLDAYVETYV TCPECGLPDT NLETDGDTIQ
LHCEACGARS TV
