ID   APD3_PIMDI              Reviewed;          20 AA.
AC   C0HKY0;
DT   30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2017, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Apidaecin Cd 3+ {ECO:0000303|PubMed:7929322};
DE   Contains:
DE     RecName: Full=Apidaecin Cd 3- {ECO:0000303|PubMed:7929322};
OS   Pimpla disparis (Parasitic wasp) (Coccygomimus disparis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida;
OC   Ichneumonoidea; Ichneumonidae; Pimplinae; Pimplini; Pimpla.
OX   NCBI_TaxID=495387 {ECO:0000303|PubMed:7929322};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Hemolymph {ECO:0000303|PubMed:7929322};
RX   PubMed=7929322; DOI=10.1016/s0021-9258(18)47165-7;
RA   Casteels P., Romagnolo J., Castle M., Casteels-Josson K.,
RA   Erdjument-Bromage H., Tempst P.;
RT   "Biodiversity of apidaecin-type peptide antibiotics. Prospects of
RT   manipulating the antibacterial spectrum and combating acquired
RT   resistance.";
RL   J. Biol. Chem. 269:26107-26115(1994).
CC   -!- FUNCTION: Antimicrobial peptide active against many Gram-negative
CC       enterobacterial and plant-associated bacterial species. Not active
CC       against other bacterial species like H.pylori, P.mirabilis, B.pertussis
CC       or N.gonorrhoeae. {ECO:0000269|PubMed:7929322}.
CC   -!- FUNCTION: [Apidaecin Cd 3+]: Among others, also active against S.typhi.
CC       {ECO:0000269|PubMed:7929322}.
CC   -!- FUNCTION: [Apidaecin Cd 3-]: Not active against S.typhi.
CC       {ECO:0000269|PubMed:7929322}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7929322}.
CC   -!- INDUCTION: By bacterial infection. {ECO:0000269|PubMed:7929322}.
CC   -!- MASS SPECTROMETRY: [Apidaecin Cd 3+]: Mass=2227.8; Method=MALDI;
CC       Note=Apidaecin Cd 3+.; Evidence={ECO:0000269|PubMed:7929322};
CC   -!- MASS SPECTROMETRY: [Apidaecin Cd 3-]: Mass=1945.3; Method=MALDI;
CC       Note=Apidaecin Cd 3-.; Evidence={ECO:0000269|PubMed:7929322};
CC   -!- SIMILARITY: Belongs to the apidaecin family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKY0; -.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Immunity;
KW   Innate immunity; Secreted.
FT   PEPTIDE         1..20
FT                   /note="Apidaecin Cd 3+"
FT                   /evidence="ECO:0000269|PubMed:7929322"
FT                   /id="PRO_0000441351"
FT   PEPTIDE         4..20
FT                   /note="Apidaecin Cd 3-"
FT                   /evidence="ECO:0000269|PubMed:7929322"
FT                   /id="PRO_0000441352"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   20 AA;  2255 MW;  87B6FE387B70AB40 CRC64;
     GKPSRPRPAP IQPRPPHPRL