ID   IF2B_METMA              Reviewed;         202 AA.
AC   Q8PWV1;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Translation initiation factor 2 subunit beta;
DE   AltName: Full=aIF2-beta;
DE   AltName: Full=eIF-2-beta;
GN   Name=eif2b; OrderedLocusNames=MM_1475;
OS   Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM
OS   11833 / OCM 88) (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=192952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88;
RX   PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene transfer
RT   between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC       forming a ternary complex with GTP and initiator tRNA. {ECO:0000250}.
CC   -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family. {ECO:0000305}.
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DR   EMBL; AE008384; AAM31171.1; -; Genomic_DNA.
DR   RefSeq; WP_011033421.1; NC_003901.1.
DR   AlphaFoldDB; Q8PWV1; -.
DR   SMR; Q8PWV1; -.
DR   STRING; 192952.MM_1475; -.
DR   EnsemblBacteria; AAM31171; AAM31171; MM_1475.
DR   GeneID; 44088908; -.
DR   GeneID; 66137098; -.
DR   KEGG; mma:MM_1475; -.
DR   PATRIC; fig|192952.21.peg.1703; -.
DR   eggNOG; arCOG01640; Archaea.
DR   HOGENOM; CLU_026663_3_0_2; -.
DR   OMA; GKPDTRL; -.
DR   Proteomes; UP000000595; Chromosome.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.50.140; -; 1.
DR   HAMAP; MF_00232; eIF_2_beta; 1.
DR   InterPro; IPR045196; IF2/IF5.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004458; TIF2_bsu_arc.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR   InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR   InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR   PANTHER; PTHR23001; PTHR23001; 1.
DR   Pfam; PF01873; eIF-5_eIF-2B; 1.
DR   Pfam; PF01938; TRAM; 1.
DR   SMART; SM00653; eIF2B_5; 1.
DR   SUPFAM; SSF100966; SSF100966; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF75689; SSF75689; 1.
DR   TIGRFAMs; TIGR00311; aIF-2beta; 1.
DR   PROSITE; PS50926; TRAM; 1.
PE   3: Inferred from homology;
KW   Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..202
FT                   /note="Translation initiation factor 2 subunit beta"
FT                   /id="PRO_0000137423"
FT   DOMAIN          145..202
FT                   /note="TRAM"
SQ   SEQUENCE   202 AA;  22471 MW;  6A91E85D4F4B9E06 CRC64;
     MYDYEELLNR AMSKMPDTET TDARFVIPEP KLFSEGKTTI LDNFGNIADT LNRDPDHLMK
     YLTRELGTAG KIEGTRAVFQ GRFTRAQLSD NIQAYVDEYV MCSECGRPDT QLVRVDRVLV
     LKCSACGAHR PVKKRKVSNV VVREAIEEGG TYELRIDAVG SKGDGIAKID KYTVFVPGAT
     KGDVVKVKIK KISGNLAFSE RA