IF2B_METTH
ID IF2B_METTH Reviewed; 135 AA.
AC O27797;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Translation initiation factor 2 subunit beta;
DE AltName: Full=aIF2-beta;
DE AltName: Full=eIF-2-beta;
GN Name=eif2b; OrderedLocusNames=MTH_1769;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
RN [2]
RP STRUCTURE BY NMR.
RX PubMed=14978306; DOI=10.1110/ps.03506604;
RA Gutierrez P., Osborne M.J., Siddiqui N., Trempe J.F., Arrowsmith C.,
RA Gehring K.;
RT "Structure of the archaeal translation initiation factor aIF2 beta from
RT Methanobacterium thermoautotrophicum: implications for translation
RT initiation.";
RL Protein Sci. 13:659-667(2004).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA. {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family. {ECO:0000305}.
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DR EMBL; AE000666; AAB86235.1; -; Genomic_DNA.
DR PIR; B69103; B69103.
DR RefSeq; WP_010877371.1; NC_000916.1.
DR PDB; 1NEE; NMR; -; A=1-135.
DR PDBsum; 1NEE; -.
DR AlphaFoldDB; O27797; -.
DR SMR; O27797; -.
DR STRING; 187420.MTH_1769; -.
DR PRIDE; O27797; -.
DR EnsemblBacteria; AAB86235; AAB86235; MTH_1769.
DR GeneID; 1470854; -.
DR KEGG; mth:MTH_1769; -.
DR PATRIC; fig|187420.15.peg.1725; -.
DR HOGENOM; CLU_026663_3_1_2; -.
DR OMA; GKPDTRL; -.
DR EvolutionaryTrace; O27797; -.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00232; eIF_2_beta; 1.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR004458; TIF2_bsu_arc.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR PANTHER; PTHR23001; PTHR23001; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SUPFAM; SSF100966; SSF100966; 1.
DR SUPFAM; SSF75689; SSF75689; 1.
DR TIGRFAMs; TIGR00311; aIF-2beta; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..135
FT /note="Translation initiation factor 2 subunit beta"
FT /id="PRO_0000137425"
FT STRAND 10..15
FT /evidence="ECO:0007829|PDB:1NEE"
FT STRAND 38..42
FT /evidence="ECO:0007829|PDB:1NEE"
FT HELIX 44..51
FT /evidence="ECO:0007829|PDB:1NEE"
FT HELIX 55..65
FT /evidence="ECO:0007829|PDB:1NEE"
FT TURN 74..76
FT /evidence="ECO:0007829|PDB:1NEE"
FT STRAND 77..82
FT /evidence="ECO:0007829|PDB:1NEE"
FT STRAND 84..86
FT /evidence="ECO:0007829|PDB:1NEE"
FT HELIX 87..96
FT /evidence="ECO:0007829|PDB:1NEE"
FT HELIX 98..102
FT /evidence="ECO:0007829|PDB:1NEE"
FT STRAND 113..115
FT /evidence="ECO:0007829|PDB:1NEE"
FT TURN 116..119
FT /evidence="ECO:0007829|PDB:1NEE"
FT STRAND 120..122
FT /evidence="ECO:0007829|PDB:1NEE"
SQ SEQUENCE 135 AA; 15587 MW; 98AF22F6966CA0AF CRC64;
MDDYEKLLER AIDQLPPEVF ETKRFEVPKA YSVIQGNRTF IQNFREVADA LNRDPQHLLK
FLLRELGTAG NLEGGRAILQ GKFTHFLINE RIEDYVNKFV ICHECNRPDT RIIREGRISL
LKCEACGAKA PLKNV
