IF2B_PYRAE
ID IF2B_PYRAE Reviewed; 134 AA.
AC Q8ZXA6;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Translation initiation factor 2 subunit beta {ECO:0000255|HAMAP-Rule:MF_00232};
DE AltName: Full=aIF2-beta {ECO:0000255|HAMAP-Rule:MF_00232};
DE AltName: Full=eIF-2-beta {ECO:0000255|HAMAP-Rule:MF_00232};
GN Name=eif2b {ECO:0000255|HAMAP-Rule:MF_00232}; OrderedLocusNames=PAE1373;
OS Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS 104966 / NBRC 100827 / IM2).
OC Archaea; Crenarchaeota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC Pyrobaculum.
OX NCBI_TaxID=178306;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2;
RX PubMed=11792869; DOI=10.1073/pnas.241636498;
RA Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I.,
RA Miller J.H.;
RT "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT aerophilum.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA.
CC {ECO:0000255|HAMAP-Rule:MF_00232}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000255|HAMAP-Rule:MF_00232}.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family. {ECO:0000255|HAMAP-
CC Rule:MF_00232}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE009441; AAL63443.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8ZXA6; -.
DR SMR; Q8ZXA6; -.
DR STRING; 178306.PAE1373; -.
DR EnsemblBacteria; AAL63443; AAL63443; PAE1373.
DR KEGG; pai:PAE1373; -.
DR PATRIC; fig|178306.9.peg.1018; -.
DR eggNOG; arCOG01640; Archaea.
DR HOGENOM; CLU_026663_3_1_2; -.
DR InParanoid; Q8ZXA6; -.
DR OMA; FIRYYVV; -.
DR Proteomes; UP000002439; Chromosome.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR HAMAP; MF_00232; eIF_2_beta; 1.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR004458; TIF2_bsu_arc.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR PANTHER; PTHR23001; PTHR23001; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SUPFAM; SSF100966; SSF100966; 1.
DR SUPFAM; SSF75689; SSF75689; 1.
PE 3: Inferred from homology;
KW Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..134
FT /note="Translation initiation factor 2 subunit beta"
FT /id="PRO_0000137429"
SQ SEQUENCE 134 AA; 15357 MW; 79B1C3DF6292A064 CRC64;
MDSEYAALLE RAYKLVAPKA QRRAEIPKIE VENMPRKTII PNFGQIAKRL NRDVYFMAKF
FQKELAVPGT LEGDVFTLHG EKSPKVVEAV YDRFIRYYVV CPVCNSIDTE LRKEGRIFIM
RCLACGASTP VRPL