IF2B_SACS2
ID IF2B_SACS2 Reviewed; 139 AA.
AC Q97W59;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Translation initiation factor 2 subunit beta {ECO:0000255|HAMAP-Rule:MF_00232};
DE AltName: Full=aIF2-beta {ECO:0000255|HAMAP-Rule:MF_00232};
DE AltName: Full=eIF-2-beta {ECO:0000255|HAMAP-Rule:MF_00232};
GN Name=eif2b {ECO:0000255|HAMAP-Rule:MF_00232}; Synonyms=aif2b;
GN OrderedLocusNames=SSO2381;
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
CC -!- FUNCTION: eIF-2 functions in the early steps of protein synthesis by
CC forming a ternary complex with GTP and initiator tRNA.
CC {ECO:0000255|HAMAP-Rule:MF_00232}.
CC -!- SUBUNIT: Heterotrimer composed of an alpha, a beta and a gamma chain.
CC {ECO:0000255|HAMAP-Rule:MF_00232}.
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family. {ECO:0000255|HAMAP-
CC Rule:MF_00232}.
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DR EMBL; AE006641; AAK42529.1; -; Genomic_DNA.
DR PIR; B90409; B90409.
DR RefSeq; WP_009989461.1; NC_002754.1.
DR PDB; 2NXU; NMR; -; A=2-139.
DR PDB; 2QMU; X-ray; 3.20 A; C=2-139.
DR PDB; 2QN6; X-ray; 2.15 A; C=2-19.
DR PDB; 3CW2; X-ray; 2.80 A; K/L/M/N=1-139.
DR PDB; 3V11; X-ray; 5.00 A; C=2-139.
DR PDB; 5JB3; EM; 5.34 A; 8=1-139.
DR PDB; 5JBH; EM; 5.34 A; 8=1-139.
DR PDB; 5K0Y; EM; 5.80 A; d=3-19.
DR PDB; 6SW9; EM; 4.20 A; 8=3-139.
DR PDB; 6SWC; EM; 3.30 A; 8=1-139.
DR PDBsum; 2NXU; -.
DR PDBsum; 2QMU; -.
DR PDBsum; 2QN6; -.
DR PDBsum; 3CW2; -.
DR PDBsum; 3V11; -.
DR PDBsum; 5JB3; -.
DR PDBsum; 5JBH; -.
DR PDBsum; 5K0Y; -.
DR PDBsum; 6SW9; -.
DR PDBsum; 6SWC; -.
DR AlphaFoldDB; Q97W59; -.
DR BMRB; Q97W59; -.
DR SMR; Q97W59; -.
DR DIP; DIP-46185N; -.
DR IntAct; Q97W59; 1.
DR STRING; 273057.SSO2381; -.
DR EnsemblBacteria; AAK42529; AAK42529; SSO2381.
DR GeneID; 44128103; -.
DR KEGG; sso:SSO2381; -.
DR PATRIC; fig|273057.12.peg.2463; -.
DR eggNOG; arCOG01640; Archaea.
DR HOGENOM; CLU_026663_3_1_2; -.
DR InParanoid; Q97W59; -.
DR OMA; GKPDTRL; -.
DR PhylomeDB; Q97W59; -.
DR BRENDA; 3.6.5.3; 6163.
DR EvolutionaryTrace; Q97W59; -.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IBA:GO_Central.
DR GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR DisProt; DP01285; -.
DR HAMAP; MF_00232; eIF_2_beta; 1.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR004458; TIF2_bsu_arc.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR PANTHER; PTHR23001; PTHR23001; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SUPFAM; SSF100966; SSF100966; 1.
DR SUPFAM; SSF75689; SSF75689; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..139
FT /note="Translation initiation factor 2 subunit beta"
FT /id="PRO_0000137434"
FT HELIX 4..15
FT /evidence="ECO:0007829|PDB:2QN6"
FT STRAND 21..23
FT /evidence="ECO:0007829|PDB:3CW2"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:3CW2"
FT STRAND 42..44
FT /evidence="ECO:0007829|PDB:2QMU"
FT STRAND 47..49
FT /evidence="ECO:0007829|PDB:3CW2"
FT TURN 50..54
FT /evidence="ECO:0007829|PDB:3CW2"
FT TURN 59..61
FT /evidence="ECO:0007829|PDB:3CW2"
FT HELIX 62..65
FT /evidence="ECO:0007829|PDB:3CW2"
FT STRAND 73..75
FT /evidence="ECO:0007829|PDB:2QMU"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:3CW2"
FT TURN 82..84
FT /evidence="ECO:0007829|PDB:3CW2"
FT STRAND 88..90
FT /evidence="ECO:0007829|PDB:2NXU"
FT TURN 95..99
FT /evidence="ECO:0007829|PDB:3CW2"
FT TURN 101..103
FT /evidence="ECO:0007829|PDB:6SWC"
FT STRAND 108..112
FT /evidence="ECO:0007829|PDB:3CW2"
FT STRAND 114..116
FT /evidence="ECO:0007829|PDB:2QMU"
FT TURN 122..124
FT /evidence="ECO:0007829|PDB:3CW2"
FT STRAND 125..130
FT /evidence="ECO:0007829|PDB:6SWC"
FT STRAND 133..136
FT /evidence="ECO:0007829|PDB:2QMU"
SQ SEQUENCE 139 AA; 15920 MW; A5C60230FDAE921C CRC64;
MSSEKEYVEM LDRLYSKLPE KGRKEGTQSL PNMIILNIGN TTIIRNFAEY CDRIRREDKI
CMKYLLKELA APGNVDDKGE LVIQGKFSSQ VINTLMERFL KAYVECSTCK SLDTILKKEK
KSWYIVCLAC GAQTPVKPL
